Serosurvey of Crimean–Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa

Ousmane Maiga International Center for Excellence in Research, Malaria Research and Training Center, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

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Miriam Andrada Sas Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Isle of Riems–Greifswald, Germany.

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Kyle Rosenke Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.

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Badian Kamissoko Central Veterinary Laboratory, Bamako, Mali.

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Marc Mertens Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Isle of Riems–Greifswald, Germany.

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Nafomon Sogoba International Center for Excellence in Research, Malaria Research and Training Center, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

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Abdallah Traore Central Veterinary Laboratory, Bamako, Mali.

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Modibo Sangare Faculty of Sciences and Techniques, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

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Mamadou Niang Central Veterinary Laboratory, Bamako, Mali.

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Tom G. Schwan Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.

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Hamidou Moussa Maiga Faculty of Sciences and Techniques, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

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Sekou F. Traore International Center for Excellence in Research, Malaria Research and Training Center, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

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Heinz Feldmann Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
Deptartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

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David Safronetz Division of Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Deptartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

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Martin H. Groschup Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Isle of Riems–Greifswald, Germany.

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DOI:
https://doi.org/10.4269/ajtmh.16-0818
Volume/Issue:
Volume 96: Issue 6
Page(s):
1341–1345
Restricted access
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Crimean–Congo hemorrhagic fever is a tick-borne disease caused by the arbovirus Crimean–Congo hemorrhagic fever virus (CCHFV, family Bunyaviridae, genus Nairovirus). CCHFV can cause a severe hemorrhagic fever with high-case fatality rates in humans. CCHFV has a wide geographic range and has been described in around 30 countries in the Middle East, Asia, Europe, and Africa including Mali and neighboring countries. To date, little is known about the prevalence rates of CCHFV in Mali. Here, using banked bovine serum samples from across the country, we describe the results of a seroepidemiological study for CCHFV aimed at identifying regions of circulation in Mali. In total, 1,074 serum samples were tested by a modified in-house CCHFV-IgG-enzyme-linked immunosorbent assay (ELISA) with confirmatory testing by commercial ELISA and immunofluorescence assay. Overall, 66% of samples tested were positive for CCHFV-specific IgG antibodies. Regional seroprevalence rates ranged from 15% to 95% and seemed to correlate with cattle density. Our results demonstrate that CCHFV prevalence is high in many regions in Mali and suggest that CCHFV surveillance should be established.

Author Notes

* Address correspondence to Heinz Feldmann, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840. E-mail: feldmannh@niaid.nih.gov
† These authors contributed equally to this work.

Financial support: This work was supported by the Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, and the International Centers for Excellence in Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Authors' addresses: Ousmane Maiga, Entomology Unit, International Center of Excellence in Research, University of Science, Techniques and Technologies of Bamako, Bamako, Mali, E-mail: ousmanem@icermali.org. Miriam Andrada Sas, Marc Mertens, and Martin H. Groschup, Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Isle of Riems–Greifswald, Germany, E-mails: miriam.sas@fli.bund.de, marc.mertens@fli.bund.de, and martin.groschup@fli.bund.de. Kyle Rosenke and Heinz Feldmann, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, Hamitlon, MT, E-mails: rosenkek@niaid.nih.gov and feldmannh@niaid.nih.gov. Badian Kamissoko, Abdallah Traore, and Mamadou Niang, Central Veterinary Laboratory, Bamako, Mali, E-mails: kbadian2001@yahoo.fr, abdalltraor@yahoo.fr, and mniangm@yahoo.fr. Nafomon Sogoba and Hamidou M. Maiga, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali, E-mails: nafomon@icermali.org and maiga_m_hamidou@yahoo.fr. Modibo Sangare, Entomology Unit, International Center for Excellence in Research Mali, Bamako, Mali, E-mail: mouadib@gwmail.gwu.edu. Tom G. Schwan, National Institute of Allergy and Infectious Diseases, Hamilton, MT, E-mail: tschwan@niaid.nih.gov. Sekou F. Traore, Filariasis Research and Training Unit, International Center of Excellence in Research, Bamako, Mali, E-mail: cheick@icermali.org. David Safronetz, Division of Zoonotic diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, E-mail: david.safronetz@phac-aspc.gc.ca.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2017
Received:
18 Oct 2016
|
Accepted:
08 Feb 2017
|
Published Online:
07 Jun 2017
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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