Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Mitjà O, Lukehart SA, Pokowas G, Moses P, Kapa A, Godornes C, Robson J, Cherian S, Houinei W, Kazadi W, Siba P, Lazzari E, Bassat Q, 2014. Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. Lancet 14: 1–7.
-
2.
Giacani L, Lukehart SA, 2014. The endemic treponematoses. Clin Microbiol Rev 27: 89–115.
-
3.
Mitjà O, Hays R, Ipai A, Wau B, Bassat Q, 2011. Osteoperiostitis in early yaws: case series and literature review. Clin Infect Dis 52: 771–774.
-
4.
Rothschild BM, 2005. History of syphilis. Clin Infect Dis 40: 1454–1463.
-
5.
Rothschild BM, Rothschild C, 1995. Treponemal disease revisited: skeletal discriminators for yaws, bejel, and venereal syphilis. Clin Infect Dis 20: 1402–1408.
-
6.
Fabricius T, Winther C, Ewertsen C, Kemp M, Dam S, 2013. Osteitis in the dens of axis caused by Treponema pallidum. BMC Infect Dis 13: 347.
-
7.
Hansen K, Hvid-Jacobsen K, Lindewald H, Sorensen PS, Weismann K. 1984. Bone lesions in early syphilis detected by bone scintigraphy. Br J Vener Dis 60: 256–258.
-
8.
Mitjà O, Hays R, Ipai A, Moses P, Paru R, de Fagaho D, Lazzari E, Bassat Q, 2012. Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial. Lancet 379: 342–347.
-
9.
Mitjà O, Houinei W, Moses P, Kapa A, Paru R, Hays R, Lukehart S, Godornes C, Bieb SV, Grice T, Siba P, Mabey D, Sanz S, Alonso PL, Asiedu K, Bassat Q, 2015. Mass treatment with single-dose azithromycin for yaws. N Engl J Med 372: 703–710.
-
10.
World Health Organization, 2012. Eradication of yaws: the Morges strategy. Wkly Epidemiol Rec 87: 189–194.
-
11.
Asiedu K, Amouzou B, Dhariwal A, Karam M, Lobo D, Patnaik S, 2008. Yaws eradication: past efforts and future perspectives. Bull World Health Organ 86: 499.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1559 | 1430 | 93 |
| Full Text Views | 344 | 9 | 0 |
| PDF Downloads | 127 | 14 | 2 |
Yaws Osteoperiostitis Treated with Single-Dose Azithromycin
Camila González-Beiras
Camila González-Beiras
Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Lisbon Institute of Hygiene and Tropical Medicine, Lisbon, Portugal.
Search for other papers by Camila González-Beiras in
Current site
Google Scholar
PubMed
Lisbon Institute of Hygiene and Tropical Medicine, Lisbon, Portugal.
Search for other papers by Camila González-Beiras in
Current site
Google Scholar
PubMed
Martí Vall-Mayans
Martí Vall-Mayans
Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.
STI Unit, University Hospital Vall d'Hebron, Barcelona, Spain.
Search for other papers by Martí Vall-Mayans in
Current site
Google Scholar
PubMed
STI Unit, University Hospital Vall d'Hebron, Barcelona, Spain.
Search for other papers by Martí Vall-Mayans in
Current site
Google Scholar
PubMed
Ángel González-Escalante
Ángel González-Escalante
Department of Imaging and Radiology, Complejo Hospitalario de Pontevedra, Pontevedra, Spain.
Search for other papers by Ángel González-Escalante in
Current site
Google Scholar
PubMed
Search for other papers by Ángel González-Escalante in
Current site
Google Scholar
PubMed
Kelly McClymont
Kelly McClymont
Department of Pathology, Sullivan Nicolaides Pathology, Brisbane, Australia.
Search for other papers by Kelly McClymont in
Current site
Google Scholar
PubMed
Search for other papers by Kelly McClymont in
Current site
Google Scholar
PubMed
Li Ma
Li Ma
Department of Pathology, Sullivan Nicolaides Pathology, Brisbane, Australia.
Search for other papers by Li Ma in
Current site
Google Scholar
PubMed
Search for other papers by Li Ma in
Current site
Google Scholar
PubMed
Oriol Mitjà
Oriol Mitjà
Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Lihir Medical Centre–International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
Search for other papers by Oriol Mitjà in
Current site
Google Scholar
PubMed
Lihir Medical Centre–International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
Search for other papers by Oriol Mitjà in
Current site
Google Scholar
PubMed
The etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands. The finding that a single oral dose of azithromycin (30 mg/kg) was as effective as benzathine benzylpenicillin prompted renewed interest by World Health Organization in 2012 toward eradication of this infection by 2020. We previously reported the excellent response to benzathine benzylpenicillin therapy for yaws osteoperiostitis. Herein, we document a confirmed case of yaws with osteoperiostitis successfully treated with single-dose azithromycin and discuss the pathology of yaws periostitis and comment on the implications of this in light of the new campaign toward yaws eradication.
Author Notes
Authors' addresses: Camila González-Beiras, Lisbon Institute of Hygiene and Tropical Medicine, Lisbon, Portugal, and Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain, E-mail: c.g.beiras@gmail.com. Martí Vall-Mayans, Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain, and STI Unit, University Hospital Vall d'Hebron, Barcelona, Spain, E-mail: marti.vall@igslobal.org. Ángel González-Escalante, Department of Imaging and Radiology, Complejo Hospitalario de Pontevedra, Pontevedra, Spain, E-mail: ag.escalante@cmpont.es. Kelly McClymont and Li Ma, Department of Pathology, Sullivan Nicolaides Pathology, Brisbane, Australia, E-mails: Kelly_McClymont@snp.com.au and Li_Ma@snp.com.au. Oriol Mitjà, Barcelona Institute for Global Health, Hospital Clínic, University of Barcelona, Barcelona, Spain, and Lisbon Institute of Hygiene and Tropical Medicine, Lisbon, Portugal, E-mail: oriolmitja@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Mitjà O, Lukehart SA, Pokowas G, Moses P, Kapa A, Godornes C, Robson J, Cherian S, Houinei W, Kazadi W, Siba P, Lazzari E, Bassat Q, 2014. Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. Lancet 14: 1–7.
-
2.
Giacani L, Lukehart SA, 2014. The endemic treponematoses. Clin Microbiol Rev 27: 89–115.
-
3.
Mitjà O, Hays R, Ipai A, Wau B, Bassat Q, 2011. Osteoperiostitis in early yaws: case series and literature review. Clin Infect Dis 52: 771–774.
-
4.
Rothschild BM, 2005. History of syphilis. Clin Infect Dis 40: 1454–1463.
-
5.
Rothschild BM, Rothschild C, 1995. Treponemal disease revisited: skeletal discriminators for yaws, bejel, and venereal syphilis. Clin Infect Dis 20: 1402–1408.
-
6.
Fabricius T, Winther C, Ewertsen C, Kemp M, Dam S, 2013. Osteitis in the dens of axis caused by Treponema pallidum. BMC Infect Dis 13: 347.
-
7.
Hansen K, Hvid-Jacobsen K, Lindewald H, Sorensen PS, Weismann K. 1984. Bone lesions in early syphilis detected by bone scintigraphy. Br J Vener Dis 60: 256–258.
-
8.
Mitjà O, Hays R, Ipai A, Moses P, Paru R, de Fagaho D, Lazzari E, Bassat Q, 2012. Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial. Lancet 379: 342–347.
-
9.
Mitjà O, Houinei W, Moses P, Kapa A, Paru R, Hays R, Lukehart S, Godornes C, Bieb SV, Grice T, Siba P, Mabey D, Sanz S, Alonso PL, Asiedu K, Bassat Q, 2015. Mass treatment with single-dose azithromycin for yaws. N Engl J Med 372: 703–710.
-
10.
World Health Organization, 2012. Eradication of yaws: the Morges strategy. Wkly Epidemiol Rec 87: 189–194.
-
11.
Asiedu K, Amouzou B, Dhariwal A, Karam M, Lobo D, Patnaik S, 2008. Yaws eradication: past efforts and future perspectives. Bull World Health Organ 86: 499.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1559 | 1430 | 93 |
| Full Text Views | 344 | 9 | 0 |
| PDF Downloads | 127 | 14 | 2 |