• 1.

    Ogbu O, Ajuluchukwu E, Uneke CJ, 2007. Lassa fever in west African sub-region: an overview. J Vector Borne Dis 44: 1–11.

  • 2.

    Fisher-Hoch SP, McCormick JB, 2004. Lassa fever vaccine. Expert Rev Vaccines 3: 189–197.

  • 3.

    O'Hearn AE, Voorhees MA, Fetterer DP, Wauquier N, Coomber MR, Bangura J, Fair JN, Gonzalez JP, Schoepp RJ, 2016. Serosurveillance of viral pathogens circulating in west Africa. Virol J 13: 163.

    • Search Google Scholar
    • Export Citation
  • 4.

    McCormick JB, Webb PA, Krebs JW, Johnson KM, Smith ES, 1987. A prospective study of the epidemiology and ecology of Lassa fever. J Infect Dis 155: 437–444.

    • Search Google Scholar
    • Export Citation
  • 5.

    Sogoba N, Feldmann H, Safronetz D, 2012. Lassa fever in west Africa: evidence for an expanded region of endemicity. Zoonoses Public Health 59 (Suppl 2): 43–47.

    • Search Google Scholar
    • Export Citation
  • 6.

    Peterson AT, Moses LM, Bausch DG, 2014. Mapping transmission risk of Lassa fever in west Africa: the importance of quality control, sampling bias, and error weighting. PLoS One 9: e100711.

    • Search Google Scholar
    • Export Citation
  • 7.

    Dzotsi EK, Ohene SA, Asiedu-Bekoe F, Amankwa J, Sarkodie B, Adjabeng M, Thouphique AM, Ofei A, Oduro J, Atitogo D, Bonney JH, Paintsil SC, Ampofo W, 2012. The first cases of Lassa fever in Ghana. Ghana Med J 46: 166–170.

    • Search Google Scholar
    • Export Citation
  • 8.

    Gunther S, Emmerich P, Laue T, Kuhle O, Asper M, Jung A, Grewing T, ter Meulen J, Schmitz H, 2000. Imported Lassa fever in Germany: molecular characterization of a new Lassa virus strain. Emerg Infect Dis 6: 466–476.

    • Search Google Scholar
    • Export Citation
  • 9.

    Wolff S, Schultze T, Fehling SK, Mengel JP, Kann G, Wolf T, Eickmann M, Becker S, Hain T, Strecker T, 2016. Genome sequence of Lassa virus isolated from the first domestically acquired case in Germany. Genome Announc 4: e00938-16.

    • Search Google Scholar
    • Export Citation
  • 10.

    Atkin S, Anaraki S, Gothard P, Walsh A, Brown D, Gopal R, Hand J, Morgan D, 2009. The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. Euro Surveill 14: 19145.

    • Search Google Scholar
    • Export Citation
  • 11.

    Safronetz D, Lopez JE, Sogoba N, Traore SF, Raffel SJ, Fischer ER, Ebihara H, Branco L, Garry RF, Schwan TG, Feldmann H, 2010. Detection of Lassa virus, Mali. Emerg Infect Dis 16: 1123–1126.

    • Search Google Scholar
    • Export Citation
  • 12.

    Sogoba N, Rosenke K, Adjemian J, Diawara SI, Maiga O, Keita M, Konate D, Keita AS, Sissoko I, Boisen M, Nelson D, Oottamasathien D, Millett M, Garry RF, Branco LM, Traore SF, Doumbia S, Feldmann H, Safronetz D, 2016. Lassa virus seroprevalence in Sibirilia Commune, Bougouni District, southern Mali. Emerg Infect Dis 22: 657–663.

    • Search Google Scholar
    • Export Citation
  • 13.

    Safronetz D, Sogoba N, Lopez JE, Maiga O, Dahlstrom E, Zivcec M, Feldmann F, Haddock E, Fischer RJ, Anderson JM, Munster VJ, Branco L, Garry R, Porcella SF, Schwan TG, Feldmann H, 2013. Geographic distribution and genetic characterization of Lassa virus in sub-Saharan Mali. PLoS Negl Trop Dis 7: e2582.

    • Search Google Scholar
    • Export Citation
  • 14.

    Johnson KM, McCormick JB, Webb PA, Smith ES, Elliott LH, King IJ, 1987. Clinical virology of Lassa fever in hospitalized patients. Infect Dis 155: 456–464.

    • Search Google Scholar
    • Export Citation

 

 

 

 

Annual Incidence of Lassa Virus Infection in Southern Mali

View More View Less
  • 1 Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada.
  • 2 University of Manitoba, Winnipeg, Canada.
  • 3 University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
  • 4 Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
  • 5 Zalgen Labs, LLC, Germantown, Maryland.
  • 6 Tulane School of Medicine, New Orleans, Louisiana.

Previously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8–8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51.7%) and two household/familial clusters were identified. These results confirm active transmission of Lassa virus is occurring in southern Mali and appropriate diagnostic testing should be established for this etiological agent of severe viral hemorrhagic fever.

Author Notes

* Address correspondence to Heinz Feldmann, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. E-mail: feldmannh@niaid.nih.gov

Financial support: This work was funded by the International Centers for Excellence in Research program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, with travel support from the Public Health Agency of Canada.

Authors' addresses: David Safronetz and L. Robbin Lindsay, National Microbiology Laboratory, Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Canada. E-mails: david.safronetz@phac-aspc.gc.ca and robbin.lindsay@phacaspc.gc.ca. Nafomon Sogoba, Sory Ibrahim Diawara, Sidy Bane, Ousmane Maiga, Sekou F. Traore, and Seydou Doumbia, Faculty of Medicine and Dentistry, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali, E-mails: nafomon@icermali.org, sdiawara@icermali.org, sbane@icermali.org, ousmanem@icermali.org, cheick@icermali.org, and sdoumbi@icermali.org. Kyle Rosenke and Heinz Feldmann, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, Hamilton, MT, E-mails: rosenkek@niaid.nih.gov and feldmannh@niaid.nih.gov. Matt Boisen and Luis M. Branco, Zalgen Labs LLC, Diagnostics, Germantown, MD, E-mails: mboisen@zalgenlabs.com and lbranco@zalgenlabs.com. Robert F. Garry, Medical Microbiology, Tulane University School of Medicine, New Orleans, LA, E-mail: rfgarry@tulane.edu.

Save