Author:
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Reference Manager
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-
1.
Staples JE, Breiman RF, Powers AM, 2009. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis 49: 942–948.
-
2.
Arroyo-Ávila M, Vilá LM, 2015. Rheumatic manifestations in patients with chikungunya infection. P R Health Sci J 34: 71–77.
-
3.
Centers for Disease Control and Prevention Website, 2016. Chikungunya Virus: Geographic Distribution. Available at: http://www.cdc.gov/chikungunya/geo/index.html. Accessed August 4, 2016.
-
4.
Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, Germonneau P, Quatresous I, 2009. Atypical chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005–2006 outbreak on Réunion. Epidemiol Infect 137: 534–541.
-
5.
Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X, 2014. Chikungunya in the Americas. Lancet 383: 514.
-
6.
Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, Wengling C, Michault A, Paganin F, 2007. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis 44: 1401–1407.
-
7.
Chopra A, Anuradha V, Ghorpade R, Saluja M, 2012. Acute chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study. Epidemiol Infect 140: 842–850.
-
8.
Win MK, Chow A, Dimatatac F, Go CJ, Leo YS, 2010. Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia. J Clin Virol 49: 111–114.
-
9.
Manimunda SP, Vijayachari P, Uppoor R, Sugunan AP, Singh SS, Rai SK, Sudeep AB, Muruganandam N, Chaitanya IK, Guruprasad DR, 2010. Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging. Trans R Soc Trop Med Hyg 104: 392–399.
-
10.
Simon F, Parola P, Grandadam M, Fourcade S, Oliver M, Brouqui P, Hance P, Kraemer P, Ali Mohamed A, de Lamballerie X, Charrel R, Tolou H, 2007. Chikungunya infection: an emerging rheumatism among travelers returned from Indian Ocean islands. Report of 47 cases. Medicine 86: 123–137.
-
11.
Sahadeo N, Mohammed H, Allicock OM, Auguste AJ, Widen SG, Badal K, Pulchan K, Foster JE, Weaver SC, Carrington CV, 2015. Molecular characterisation of chikungunya virus infections in Trinidad and comparison of clinical and laboratory features with dengue and other acute febrile cases. PLoS Negl Trop Dis 9: e0004199.
-
12.
Mattar S, Miranda J, Pinzon H, Tique V, Bolanos A, Aponte J, Arrieta G, Gonzalez M, Barrios K, Contreras H, Alvarez J, Aleman A, 2015. Outbreak of chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis. J Infect Dev Ctries 9: 1126–1132.
-
13.
Sissoko D, Malvy D, Ezzedine K, Renault P, Moscetti F, Ledrans M, Pierre V, 2009. Post-epidemic chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period. PLoS Negl Trop Dis 3: e389.
-
14.
Schilte C, Staikowsky F, Couderc T, Madec Y, Carpentier F, Kassab S, Albert ML, Lecuit M, Michault A, 2013. Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study. PLoS Negl Trop Dis 7: e2137.
-
15.
Borgherini G, Poubeau P, Jossaume A, Gouix A, Cotte L, Michault A, Arvin-Berod C, Paganin F, 2008. Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on Reunion Island. Clin Infect Dis 47: 469–475.
-
16.
Essackjee K, Goorah S, Ramchurn SK, Cheeneebash J, Walker-Bone K, 2013. Prevalence of and risk factors for chronic arthralgia and rheumatoid-like polyarthritis more than 2 years after infection with chikungunya virus. Postgrad Med J 89: 440–447.
-
17.
Larrieu S, Pouderoux N, Pistone T, Filleul L, Receveur MC, Sissoko D, Ezzedine K, Malvy D, 2010. Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: report of 42 French cases. J Clin Virol 47: 85–88.
-
18.
Bouquillard E, Combe B, 2009. A report of 21 cases of rheumatoid arthritis following chikungunya fever. A mean follow-up of two years. Joint Bone Spine 76: 654–657.
-
19.
Panning M, Grywna K, van Esbroeck M, Emmerich P, Drosten C, 2008. Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006. Emerg Infect Dis 14: 416–422.
-
20.
Malvy D, Ezzedine K, Mamani-Matsuda M, Autran B, Tolou H, Receveur MC, Pistone T, Rambert J, Moynet D, Mossalayi D, 2009. Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. BMC Infect Dis 9: 200.
-
21.
Mathew AJ, Goyal V, George E, Thekkemuriyil DV, Jayakumar B, Chopra A, Trivandrum COPCORD Study Group, 2011. Rheumatic-musculoskeletal pain and disorders in a naïve group of individuals 15 months following a chikungunya viral epidemic in south India: a population based observational study. Int J Clin Pract 65: 1306–1312.
-
22.
Gérardin P, Fianu A, Michault A, Mussard C, Boussaïd K, Rollot O, Grivard P, Kassab S, Bouquillard E, Borgherini G, Gaüzère BA, Malvy D, Bréart G, Favier F, 2013. Predictors of chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study. Arthritis Res Ther 15: R9.
-
23.
Balmaseda A, Gordon A, Gresh L, Ojeda S, Saborio S, Tellez Y, Sanchez N, Kuan G, Harris E, 2016. Clinical attack rate of chikungunya in a cohort of Nicaraguan children. Am J Trop Med Hyg 94: 397–399.
-
24.
Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X, 2013. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, south-west Indian Ocean. PLoS Negl Trop Dis 7: e2004.
-
25.
Mohd Zim MA, Sam IC, Omar SF, Chan YF, AbuBakar S, Kamarulzaman A, 2013. Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. J Clin Virol 56: 141–145.
-
26.
Feldstein LR, Ellis EM, Rowhani-Rahbar A, Halloran ME, Ellis BR, 2016. The first reported outbreak of chikungunya in the U.S. Virgin Islands, 2014–2015. Am J Trop Med Hyg 95: 885–889.
-
27.
Miner JJ, Aw Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AH, Diamond MS, Lenschow DJ, Yokoyama WM, 2015. Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 67: 1214–1220.
-
28.
Berry A, Brousseau D, Brotanek JM, Tomany-Korman S, Flores G, 2008. Why do parents bring children to the emergency department for nonurgent conditions? A qualitative study. Ambul Pediatr 8: 360–367.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 30 | 30 | 9 |
| Full Text Views | 296 | 83 | 1 |
| PDF Downloads | 97 | 18 | 0 |
Clinical Manifestations Associated with Peripheral Joint Involvement in Patients with Acute Chikungunya Virus Infection
Mariangelí Arroyo-Ávila
Mariangelí Arroyo-Ávila
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Amanda Cabán
Amanda Cabán
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Enid J. García-Rivera
Enid J. García-Rivera
Endowed Health Services Research Center, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Marisela Irizarry-Pérez
Marisela Irizarry-Pérez
Endowed Health Services Research Center, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Hilda Torres
Hilda Torres
Endowed Health Services Research Center, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Héctor Gorbea
Héctor Gorbea
Division of Infectious Diseases, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Luis M. Vilá
Luis M. Vilá
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
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Chikungunya virus (CHIKV) causes an acute febrile illness usually accompanied by severe polyarthralgia and polyarthritis. Previous studies have shown that older age, female gender, and some comorbid conditions are associated with chronic CHIKV arthritis. However, the factors associated with acute arthralgia and arthritis are not well known. Thus, we studied the clinical manifestations associated with acute peripheral joint involvement in a group of CHIKV patients from Puerto Rico. Patients with a history of fever for < 7 days evaluated at the emergency department of a university-based hospital were tested for several pathogens including CHIKV. All patients with laboratory-positive CHIKV infection were studied. Demographic features, clinical manifestations, and comorbidities were determined. Patients with and without peripheral joint involvement were compared using bivariable and multivariable analyses. In total, 172 patients with CHIKV fever were evaluated; 52.9% were women. The mean (standard deviation) age was 21.1 years (19.3). Peripheral arthralgia and/or arthritis were seen in 156 (90.7%) patients. In the multivariable analysis adjusted for age and gender, peripheral joint involvement was associated with myalgia (odds ratio [OR] = 4.65, 95% confidence interval [CI] = 1.48–14.72), back pain (OR = 16.77, 95% CI = 3.07–313.82), ocular pain (OR = 8.88, 95% CI = 1.65–165.19), headache (OR = 3.63, 95% CI = 1.06–12.53), anorexia (OR = 5.68, 95% CI = 1.87–18.97), and nausea (OR = 6.88, 95% CI = 2.05–31.49). In conclusion, in this population of patients with acute CHIKV infection, peripheral joint involvement was associated with myalgia and back pain as well as nonmusculoskeletal manifestations such as headache, ocular pain, anorexia, and nausea.
Author Notes
Financial support: This project was supported with Grant 5U01CK000274 from the Centers for Disease Control and Prevention and Grants 5S21MD000242 and 5S21MD000138 from the National Center for Minority Health and Health Disparities, National Institutes of Health.
Authors' addresses: Mariangelí Arroyo-Ávila, Amanda Cabán, and Luis M. Vilá, Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, E-mails: mariangeli.arroyo@upr.edu, amanda.caban@gmail.com, and luis.vila2@upr.edu. Enid J. García-Rivera, Marisela Irizarry-Pérez, and Hilda Torres, Endowed Health Services Research Center, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, E-mails: enid.garcia3@upr.edu, marisela.irizarry@gmail.com, and hilda.torres1@upr.edu. Héctor Gorbea, Division of Infectious Diseases, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, E-mail: hector.gorbea@upr.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Staples JE, Breiman RF, Powers AM, 2009. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis 49: 942–948.
-
2.
Arroyo-Ávila M, Vilá LM, 2015. Rheumatic manifestations in patients with chikungunya infection. P R Health Sci J 34: 71–77.
-
3.
Centers for Disease Control and Prevention Website, 2016. Chikungunya Virus: Geographic Distribution. Available at: http://www.cdc.gov/chikungunya/geo/index.html. Accessed August 4, 2016.
-
4.
Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, Germonneau P, Quatresous I, 2009. Atypical chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005–2006 outbreak on Réunion. Epidemiol Infect 137: 534–541.
-
5.
Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, de Lamballerie X, 2014. Chikungunya in the Americas. Lancet 383: 514.
-
6.
Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, Wengling C, Michault A, Paganin F, 2007. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis 44: 1401–1407.
-
7.
Chopra A, Anuradha V, Ghorpade R, Saluja M, 2012. Acute chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study. Epidemiol Infect 140: 842–850.
-
8.
Win MK, Chow A, Dimatatac F, Go CJ, Leo YS, 2010. Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia. J Clin Virol 49: 111–114.
-
9.
Manimunda SP, Vijayachari P, Uppoor R, Sugunan AP, Singh SS, Rai SK, Sudeep AB, Muruganandam N, Chaitanya IK, Guruprasad DR, 2010. Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging. Trans R Soc Trop Med Hyg 104: 392–399.
-
10.
Simon F, Parola P, Grandadam M, Fourcade S, Oliver M, Brouqui P, Hance P, Kraemer P, Ali Mohamed A, de Lamballerie X, Charrel R, Tolou H, 2007. Chikungunya infection: an emerging rheumatism among travelers returned from Indian Ocean islands. Report of 47 cases. Medicine 86: 123–137.
-
11.
Sahadeo N, Mohammed H, Allicock OM, Auguste AJ, Widen SG, Badal K, Pulchan K, Foster JE, Weaver SC, Carrington CV, 2015. Molecular characterisation of chikungunya virus infections in Trinidad and comparison of clinical and laboratory features with dengue and other acute febrile cases. PLoS Negl Trop Dis 9: e0004199.
-
12.
Mattar S, Miranda J, Pinzon H, Tique V, Bolanos A, Aponte J, Arrieta G, Gonzalez M, Barrios K, Contreras H, Alvarez J, Aleman A, 2015. Outbreak of chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis. J Infect Dev Ctries 9: 1126–1132.
-
13.
Sissoko D, Malvy D, Ezzedine K, Renault P, Moscetti F, Ledrans M, Pierre V, 2009. Post-epidemic chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period. PLoS Negl Trop Dis 3: e389.
-
14.
Schilte C, Staikowsky F, Couderc T, Madec Y, Carpentier F, Kassab S, Albert ML, Lecuit M, Michault A, 2013. Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study. PLoS Negl Trop Dis 7: e2137.
-
15.
Borgherini G, Poubeau P, Jossaume A, Gouix A, Cotte L, Michault A, Arvin-Berod C, Paganin F, 2008. Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on Reunion Island. Clin Infect Dis 47: 469–475.
-
16.
Essackjee K, Goorah S, Ramchurn SK, Cheeneebash J, Walker-Bone K, 2013. Prevalence of and risk factors for chronic arthralgia and rheumatoid-like polyarthritis more than 2 years after infection with chikungunya virus. Postgrad Med J 89: 440–447.
-
17.
Larrieu S, Pouderoux N, Pistone T, Filleul L, Receveur MC, Sissoko D, Ezzedine K, Malvy D, 2010. Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: report of 42 French cases. J Clin Virol 47: 85–88.
-
18.
Bouquillard E, Combe B, 2009. A report of 21 cases of rheumatoid arthritis following chikungunya fever. A mean follow-up of two years. Joint Bone Spine 76: 654–657.
-
19.
Panning M, Grywna K, van Esbroeck M, Emmerich P, Drosten C, 2008. Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006. Emerg Infect Dis 14: 416–422.
-
20.
Malvy D, Ezzedine K, Mamani-Matsuda M, Autran B, Tolou H, Receveur MC, Pistone T, Rambert J, Moynet D, Mossalayi D, 2009. Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. BMC Infect Dis 9: 200.
-
21.
Mathew AJ, Goyal V, George E, Thekkemuriyil DV, Jayakumar B, Chopra A, Trivandrum COPCORD Study Group, 2011. Rheumatic-musculoskeletal pain and disorders in a naïve group of individuals 15 months following a chikungunya viral epidemic in south India: a population based observational study. Int J Clin Pract 65: 1306–1312.
-
22.
Gérardin P, Fianu A, Michault A, Mussard C, Boussaïd K, Rollot O, Grivard P, Kassab S, Bouquillard E, Borgherini G, Gaüzère BA, Malvy D, Bréart G, Favier F, 2013. Predictors of chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study. Arthritis Res Ther 15: R9.
-
23.
Balmaseda A, Gordon A, Gresh L, Ojeda S, Saborio S, Tellez Y, Sanchez N, Kuan G, Harris E, 2016. Clinical attack rate of chikungunya in a cohort of Nicaraguan children. Am J Trop Med Hyg 94: 397–399.
-
24.
Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X, 2013. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, south-west Indian Ocean. PLoS Negl Trop Dis 7: e2004.
-
25.
Mohd Zim MA, Sam IC, Omar SF, Chan YF, AbuBakar S, Kamarulzaman A, 2013. Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia. J Clin Virol 56: 141–145.
-
26.
Feldstein LR, Ellis EM, Rowhani-Rahbar A, Halloran ME, Ellis BR, 2016. The first reported outbreak of chikungunya in the U.S. Virgin Islands, 2014–2015. Am J Trop Med Hyg 95: 885–889.
-
27.
Miner JJ, Aw Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AH, Diamond MS, Lenschow DJ, Yokoyama WM, 2015. Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 67: 1214–1220.
-
28.
Berry A, Brousseau D, Brotanek JM, Tomany-Korman S, Flores G, 2008. Why do parents bring children to the emergency department for nonurgent conditions? A qualitative study. Ambul Pediatr 8: 360–367.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 30 | 30 | 9 |
| Full Text Views | 296 | 83 | 1 |
| PDF Downloads | 97 | 18 | 0 |