Author:
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1.
Morrison TE, 2014. Reemergence of chikungunya virus. J Virol 88: 11644–11647.
-
2.
Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M, Robillard PY, 2008. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Reunión. PLoS 5: e60.
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3.
Robillard PY, Boumahni B, Gérardin P, Michault A, Fourmaintraux A, Schuffenecker I, Carbonnier M, Djémili S, Choker G, Roge-Wolter M, Barau G, 2006. Vertical maternal fetal transmission of chikungunya virus. Ten cases among 84 pregnant women. Presse Med 35: 785–788.
-
4.
Ramful D, Carbonnier M, Pasquet M, Bouhmani B, Ghazouani J, Noormahomed T, Beullier G, Attali T, Samperiz S, Fourmaintraux A, Alessandri JL, 2007. Mother-to-child transmission of chikungunya virus infection. Pediatr Infect Dis J 26: 811–815.
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Pan American Health Orgaziation (PAHO)/Centers for Disease Control and Prevention, 2011. Preparedness and Response for Chikungunya Virus in the Americas. Washington, DC: PAHO. Available at: http://www1.paho.org/hq/dmdocuments/CHIKV_English.pdf. Accessed September 6, 2016.
-
6.
Valamparampil JJ, Chirakkarot S, Letha S, Jayakumar C, Gopinatham KM, 2009. Clinical profile of chikungunya in infants. Indian J Pediatr 76: 151–155.
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7.
Sebastian M, Lodha R, Kabra SK, 2009. Chikungunya infection in children. Indian J Pediatr 76: 185–189.
-
8.
Parola P, Simon F, Oliver M, 2007. Tenosynovitis and vascular disorders associated with chikungunya virus-related rheumatism. Clin Infect Dis 45: 801–802.
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9.
Harel L, Straussberg R, Rudich H, Cohen AH, Amir J, 2000. Raynaud's phenomenon as a manifestation of parvovirus B-19 infection: case reports and review of parvovirus B19 rheumatic and vasculitic syndromes. Clin Infect Dis 30: 500–503.
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10.
Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Cayet N, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML, Lecuit M, 2008. A mouse model for chikungunya: young and inefficient type-1 interferon signaling are risk factors for severe disease. PLoS Pathog 4: e29.
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11.
Bordi L, Caglioti C, Lalle E, Castilleti C, Capobianchi MR, 2015. Chikungunya and its interaction with the host cell. Curr Trop Med Rep 2: 22–29.
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12.
Dowling D, Levy O, 2014. Ontogeny of early life immunity. Trends Immunol 35: 299–310.
-
13.
Kollmann TR, Levy O, Montgomery RR, Goriely S, 2012. Innate immune function by toll-like receptors: distinct responses in newborn and the elderly. Immunity 37: 771–783.
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Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection
Tracy Evans-Gilbert
Tracy Evans-Gilbert
Department of Paediatrics, Cornwall Regional Hospital, Montego Bay, Jamaica.
Department of Child and Adolescent Health, University of the West Indies, Kingston, Jamaica.
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Department of Child and Adolescent Health, University of the West Indies, Kingston, Jamaica.
Search for other papers by Tracy Evans-Gilbert in
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Chikungunya is a mosquito-borne infectious disease that has emerged as a global pathogen. The virus can pass vertically from mother to child especially during the perinatal period, with an intrapartum vertical transmission rate of 50%. Approximately half of the neonates infected with chikungunya present with severe symptoms and infrequently death. This report summarizes two severe cases of vertically transmitted neonatal chikungunya infection. One case was confirmed by real-time reverse transcription polymerase chain reaction and the other fulfilled clinical and epidemiological criteria. Both infants presented on day 3 with abdominal distension, reduced perfusion pressure, and hypotension; acrocyanosis progressing to ischemic digits; and respiratory distress. Both died within 24–48 hours of presentation. The severity of symptoms observed is likely due to a combination of contamination of the fetal blood from highly viremic mothers during delivery and a low innate antiviral type-1 interferon response. Further examination of the neonate's innate immune response to chikungunya may provide clues for the development of potential treatment or vaccine interventions.
Author Notes
Author's address: Tracy Evans-Gilbert, Department of Paediatrics, Cornwall Regional Hospital, Montego Bay, Jamaica, E-mail: tracybabydoc@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Morrison TE, 2014. Reemergence of chikungunya virus. J Virol 88: 11644–11647.
-
2.
Gérardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G, Lenglet Y, Touret Y, Bouveret A, Grivard P, Le Roux K, Blanc S, Schuffenecker I, Couderc T, Arenzana-Seisdedos F, Lecuit M, Robillard PY, 2008. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Reunión. PLoS 5: e60.
-
3.
Robillard PY, Boumahni B, Gérardin P, Michault A, Fourmaintraux A, Schuffenecker I, Carbonnier M, Djémili S, Choker G, Roge-Wolter M, Barau G, 2006. Vertical maternal fetal transmission of chikungunya virus. Ten cases among 84 pregnant women. Presse Med 35: 785–788.
-
4.
Ramful D, Carbonnier M, Pasquet M, Bouhmani B, Ghazouani J, Noormahomed T, Beullier G, Attali T, Samperiz S, Fourmaintraux A, Alessandri JL, 2007. Mother-to-child transmission of chikungunya virus infection. Pediatr Infect Dis J 26: 811–815.
-
5.
Pan American Health Orgaziation (PAHO)/Centers for Disease Control and Prevention, 2011. Preparedness and Response for Chikungunya Virus in the Americas. Washington, DC: PAHO. Available at: http://www1.paho.org/hq/dmdocuments/CHIKV_English.pdf. Accessed September 6, 2016.
-
6.
Valamparampil JJ, Chirakkarot S, Letha S, Jayakumar C, Gopinatham KM, 2009. Clinical profile of chikungunya in infants. Indian J Pediatr 76: 151–155.
-
7.
Sebastian M, Lodha R, Kabra SK, 2009. Chikungunya infection in children. Indian J Pediatr 76: 185–189.
-
8.
Parola P, Simon F, Oliver M, 2007. Tenosynovitis and vascular disorders associated with chikungunya virus-related rheumatism. Clin Infect Dis 45: 801–802.
-
9.
Harel L, Straussberg R, Rudich H, Cohen AH, Amir J, 2000. Raynaud's phenomenon as a manifestation of parvovirus B-19 infection: case reports and review of parvovirus B19 rheumatic and vasculitic syndromes. Clin Infect Dis 30: 500–503.
-
10.
Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Cayet N, Schuffenecker I, Desprès P, Arenzana-Seisdedos F, Michault A, Albert ML, Lecuit M, 2008. A mouse model for chikungunya: young and inefficient type-1 interferon signaling are risk factors for severe disease. PLoS Pathog 4: e29.
-
11.
Bordi L, Caglioti C, Lalle E, Castilleti C, Capobianchi MR, 2015. Chikungunya and its interaction with the host cell. Curr Trop Med Rep 2: 22–29.
-
12.
Dowling D, Levy O, 2014. Ontogeny of early life immunity. Trends Immunol 35: 299–310.
-
13.
Kollmann TR, Levy O, Montgomery RR, Goriely S, 2012. Innate immune function by toll-like receptors: distinct responses in newborn and the elderly. Immunity 37: 771–783.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 31 | 31 | 13 |
| Full Text Views | 434 | 154 | 1 |
| PDF Downloads | 154 | 50 | 0 |