Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
2.
Da Mata JR, Camargos ERS, Chian E, Machado CRS, 2000. Trypanosoma cruzi infection and the rat central nervous system: proliferation of parasites in astrocytes and the brain reaction to parasitism. Brain Res Bull 53: 153–162.
-
3.
Pagano MA, Segura MJ, Di Lorenzo GA, Garau ML, Molina HA, Cahn P, Perez H, Vítolo F, Grondona A, Piedimonte FC, Giannuaula R, Ramia R, Miranda MA, Sierra H, Sica REP, 1999. Cerebral tumor-like American tryoanosomiasis in acquired immunodeficiency syndrome. Ann Neurol 45: 403–406.
-
4.
Pimentel PCA, Handfas BW, Carmignani M, 1996. Trypanossoma cruzi meningoencephalitis in AIDS mimicking cerebral metastases. Arq Neuropsiquiatr 54: 102–106.
-
5.
Cordova E, Maiolo E, Corti M, Orduña T, 2010. Neurological manifestations of Chagas' disease. Neurol Res 32: 238–244.
-
6.
Cordova E, Boschi A, Ambrosioni J, Cudos C, Corti M, 2008. Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007. Int J Infect Dis 12: 587–592.
-
7.
Pittella JEH, 2009. Central nervous system involvement in Chagas disease: a hundred-year-old history. Trans R Soc Trop Med Hyg 103: 973–978.
-
8.
Chagas C, 1911. Nova entidade mórbida do homem: rezumo geral dos estudos etiológicos e clínicos. Mem Inst Oswaldo Cruz 3: 219–275.
-
9.
Prata A, 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92–100.
-
10.
Pinazo MJ, Espinosa G, Cortes-Lletget C, Posada EJ, Aldasoro E, Oliveira I, Muñoz J, Gállego M, Gascon J, 2013. Immunosuppression and Chagas disease: a management challenge. PLoS Negl Trop Dis 7: e1965.
-
11.
Ferreira MS, Borges AS, 2002. Some aspects of protozoan infections in immunocompromised patients—a review. Mem Inst Oswaldo Cruz 97: 443–457.
-
12.
Sica REP, Gargiullo G, Papayanis C, 2008. Tumor-like chagasic encephalitis in AIDS patients. Arq Neuropsiquiatr 66: 881–884.
-
13.
Burgos JM, Begher S, Silva HMV, Bisio M, Duffy T, Levin MJ, Macedo AM, Schijman AG, 2008. Case report: molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS. Am J Trop Med Hyg 78: 294–297.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 36 | 36 | 15 |
| Full Text Views | 280 | 91 | 1 |
| PDF Downloads | 110 | 38 | 0 |
Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient Without Known Immunosuppression
Herbert J. Fernandes
Herbert J. Fernandes
Hospital Eduardo de Menezes, Minas Gerais, Brazil.
Search for other papers by Herbert J. Fernandes in
Current site
Google Scholar
PubMed
Search for other papers by Herbert J. Fernandes in
Current site
Google Scholar
PubMed
Luanda O. F. Barbosa
Luanda O. F. Barbosa
Hospital da Baleia, Minas Gerais, Brazil.
Search for other papers by Luanda O. F. Barbosa in
Current site
Google Scholar
PubMed
Search for other papers by Luanda O. F. Barbosa in
Current site
Google Scholar
PubMed
Tamara S. Machado
Tamara S. Machado
Hospital Eduardo de Menezes, Minas Gerais, Brazil.
Search for other papers by Tamara S. Machado in
Current site
Google Scholar
PubMed
Search for other papers by Tamara S. Machado in
Current site
Google Scholar
PubMed
João Paulo R. Campos
João Paulo R. Campos
Hospital da Baleia, Minas Gerais, Brazil.
Search for other papers by João Paulo R. Campos in
Current site
Google Scholar
PubMed
Search for other papers by João Paulo R. Campos in
Current site
Google Scholar
PubMed
Alexandre S. Moura
Alexandre S. Moura
Hospital Eduardo de Menezes, Minas Gerais, Brazil.
Search for other papers by Alexandre S. Moura in
Current site
Google Scholar
PubMed
Search for other papers by Alexandre S. Moura in
Current site
Google Scholar
PubMed
Central nervous system (CNS) involvement in Chagas disease (CD) is an uncommon complication that can result from direct involvement of the parasite or from thromboembolic phenomena. Direct involvement of CNS can occur in both acute and chronic forms of CD, and can also be secondary to reactivation. Reactivation of CD generally occurs in immunosuppressed patients such as those with human immunodeficiency infection or malignancies being rarely described in patients without apparent immunosuppression. We report a case of a patient living for many years in a nonendemic area for CD that presented to the emergency department with sudden onset of neurological symptoms as a result of reactivation of the disease. The microorganism was isolated from cerebrospinal fluid, and despite appropriate use of benznidazole, the patient died of sepsis after 22 days of treatment. Further investigation did not show any apparent cause of immunosuppression. This case report shows the importance of considering the diagnostic possibility of neurological complications from CD reactivation in patients that have ever lived in CD-endemic areas even without apparent underlying immunosuppression.
Author Notes
Authors' addresses: Herbert J. Fernandes, Tamara S. Machado, and Alexandre S. Moura, Infectious Diseases Service, Hospital Eduardo de Menezes, Minas Gerais, Brazil, E-mails: herbert_fern@hotmail.com, tamarasmachado@yahoo.com.br, and alexandresmoura@gmail.com. Luanda O. F. Barbosa, Internal Medicine, Hospital da Baleia, Minas Gerais, Brazil, E-mail: luanda_ferreira@hotmail.com. João Paulo R. Campos, Internal Medicine, Hospital da Baleia, Minas Gerais, Brazil, and Infectious Diseases Service, Hospital Eduardo de Menezes, Minas Gerais, Brazil, E-mail: jprcampos@gmail.com.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
2.
Da Mata JR, Camargos ERS, Chian E, Machado CRS, 2000. Trypanosoma cruzi infection and the rat central nervous system: proliferation of parasites in astrocytes and the brain reaction to parasitism. Brain Res Bull 53: 153–162.
-
3.
Pagano MA, Segura MJ, Di Lorenzo GA, Garau ML, Molina HA, Cahn P, Perez H, Vítolo F, Grondona A, Piedimonte FC, Giannuaula R, Ramia R, Miranda MA, Sierra H, Sica REP, 1999. Cerebral tumor-like American tryoanosomiasis in acquired immunodeficiency syndrome. Ann Neurol 45: 403–406.
-
4.
Pimentel PCA, Handfas BW, Carmignani M, 1996. Trypanossoma cruzi meningoencephalitis in AIDS mimicking cerebral metastases. Arq Neuropsiquiatr 54: 102–106.
-
5.
Cordova E, Maiolo E, Corti M, Orduña T, 2010. Neurological manifestations of Chagas' disease. Neurol Res 32: 238–244.
-
6.
Cordova E, Boschi A, Ambrosioni J, Cudos C, Corti M, 2008. Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992–2007. Int J Infect Dis 12: 587–592.
-
7.
Pittella JEH, 2009. Central nervous system involvement in Chagas disease: a hundred-year-old history. Trans R Soc Trop Med Hyg 103: 973–978.
-
8.
Chagas C, 1911. Nova entidade mórbida do homem: rezumo geral dos estudos etiológicos e clínicos. Mem Inst Oswaldo Cruz 3: 219–275.
-
9.
Prata A, 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92–100.
-
10.
Pinazo MJ, Espinosa G, Cortes-Lletget C, Posada EJ, Aldasoro E, Oliveira I, Muñoz J, Gállego M, Gascon J, 2013. Immunosuppression and Chagas disease: a management challenge. PLoS Negl Trop Dis 7: e1965.
-
11.
Ferreira MS, Borges AS, 2002. Some aspects of protozoan infections in immunocompromised patients—a review. Mem Inst Oswaldo Cruz 97: 443–457.
-
12.
Sica REP, Gargiullo G, Papayanis C, 2008. Tumor-like chagasic encephalitis in AIDS patients. Arq Neuropsiquiatr 66: 881–884.
-
13.
Burgos JM, Begher S, Silva HMV, Bisio M, Duffy T, Levin MJ, Macedo AM, Schijman AG, 2008. Case report: molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS. Am J Trop Med Hyg 78: 294–297.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 36 | 36 | 15 |
| Full Text Views | 280 | 91 | 1 |
| PDF Downloads | 110 | 38 | 0 |