- Introduction
- Materials and Methods
- Results
- Clinical features of HIV–VL coinfection.
- Comparison of clinical features, laboratory diagnostics, and treatment outcomes between patients with VL monoinfection and HIV–VL coinfection.
- Treatment and secondary prophylaxis in patients with HIV–VL coinfection (Figure 1).
- Primary and secondary outcomes.
- Survival analysis.
- Discussion
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Protective Efficacy of Secondary Prophylaxis Against Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients Over the Past 10 Years in Eastern India
Coinfection with visceral leishmaniasis (VL) and human immunodeficiency virus (HIV) leads to frequent treatment failure, relapse, and death. In this retrospective analysis from eastern India (2005–2015), our primary objective was to ascertain the protective efficacy of secondary prophylaxis with monthly amphotericin B (AmB) given in patients with HIV–VL coinfection toward reducing relapse and mortality rates. The secondary objective was to compare clinical features, laboratory findings, and treatment outcomes in HIV–VL patients in contrast to VL monoinfection. Overall, 53 cases of HIV–VL and 460 cases of VL monoinfection were identified after excluding incomplete records. Initial cure rate was 96.23% in HIV–VL (27 received liposomal AmB and 26 AmB deoxycholate). All patients with initial cure (N = 51) were given antiretroviral therapy. Secondary prophylaxis (N = 27) was provided with monthly 1 mg/kg AmB (15 liposomal, 12 deoxycholate). No relapse or death was noted within 6 months in the secondary prophylaxis group (relapse: none versus 18/24 [75%]; mortality: none versus 11/24 [45.8%]; P < 0.001 for both). Secondary prophylaxis remained the sole significant predictor against death in multivariate Cox regression model (hazard ratio = 0.09 [95% confidence interval = 0.03–0.31]; P < 0.001). HIV–VL patients had higher 6-month relapse rate, less relapse-free 12-month survival, and higher mortality (P < 0.001 each) than VL monoinfection. In conclusion, it appears from this study that secondary prophylaxis with monthly AmB might be effective in preventing relapse and mortality in HIV–VL.
Author Notes
Authors' addresses: Rama P. Goswami, Ayan Basu, Yogiraj Ray, and Mehebubar Rahman, Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India, E-mails: drrpgoswami@gmail.com, ayanbasustm@gmail.com, jaggs.nbmc@gmail.com, and rmehbub@gmail.com. Rudra P. Goswami, Department of Rheumatology, Institution of Post Graduate Medical Education and Research, Kolkata, India, E-mail: rudra.goswami@gmail.com. Santanu K. Tripathi, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India, E-mail: tripathi.santanu@gmail.com.