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1.
Dejeux P, 2004. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27: 305–318.
-
2.
de Silva AA, Pacheco e Silva Filho Á, Sesso R de C, Esmeraldo R de M, de Oliveira CM, Fernandes PF, de Oliveira RA, de Silva LS, de Carvalho VP, Costa CH, Andrade JX, da Silva DM, Chaves RV, 2015. Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases. BMC Infect Dis 15: 96.
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3.
Cousins S, 2015. India makes good progress in combating kala-azar. Lancet 385: 1716.
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4.
Andrade ZA, 1959. Pneumonite intersticial no calazar. Hospital 55: 371–381.
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5.
Duarte MI, Da Matta VL, Corbett CE, Laurenti MD, Chebabo R, Goto H, 1989. Interstitial pneumonitis in human visceral leishmaniasis. Trans R Soc Trop Med Hyg 83: 73–76.
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6.
Druzian AF, de Souza AS, de Campos DN, Croda J, Higa MG Jr, Dorval ME, Pompilio MA, de Oliveira PA, Paniago AM, 2015. Risk factors for death from visceral leishmaniasis in an urban area of Brazil. PLoS Negl Trop Dis 9: e0003982.
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7.
Duarte MI, Laurenti MD, Brandão Nunes VL, Rego Júnior FA, Oshiro ET, Corbett CE, 1986. Interstitial pneumonitis in canine visceral leishmaniasis. Rev Inst Med Trop Sao Paulo 28: 431–436.
-
8.
Tuon FF, Guedes F, Fernandes ER, Pagliari C, Amato VS, Seixas Duarte MI, 2009. In situ immune responses to interstitial pneumonitis in human visceral leishmaniasis. Parasite Immunol 31: 98–103.
-
9.
Silva LC, Castro RS, Figueiredo MM, Michalick MS, Tafuri WL, Tafuri WL, 2013. Canine visceral leishmaniasis as a systemic fibrotic disease. Int J Exp Pathol 94: 133–143.
-
10.
Hayes D Jr, Kraman SS, 2009. The physiologic basis of spirometry. Respir Care 54: 1717–1726.
-
11.
Escobar H, Carver TW Jr, 2011. Pulmonary function testing in young children. Curr Allergy Asthma Rep 11: 473–481.
-
12.
Ramsey KA, Ranganathan S, Park J, Skoric B, Adams AM, Simpson SJ, Robins-Browne RM, Franklin PJ, de Klerk NH, Sly PD, Stick SM, Hall GL, Arest CF, 2014. Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis. Am J Respir Crit Care Med 190: 1111–1116.
-
13.
Pereira CA, 2002. II Consenso de Espirometria. J Pneumol 28: s1–s80.
-
14.
Georgiadou SP, Stefos A, Spanakos G, Skrimpas S, Makaritsis K, Sipsas NV, Dalekos GN, 2015. Current clinical, laboratory and treatment outcome characteristics of visceral leishmaniasis: results from a seven-year retrospective study in Greece. Int J Infect Dis 34: 46–50.
-
15.
Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O'Donnell DE, Aaron SD; CanCOLD Collaborative Research Group, 2015. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax 70: 822–829.
-
16.
Gan WQ, Man SF, Senthilselvan A, Sin DD, 2004. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 59: 574–580.
-
17.
Lunt A, McGhee E, Robinson P, Rees D, Height S, Greenough A, 2016. Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease. Respir Physiol Neurobiol 222: 6–10.
-
18.
Murray HW, 2004. Treatment of visceral leishmaniasis in 2004. Am J Trop Med Hyg 71: 787–794 (Review).
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 17 | 17 | 3 |
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Disease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil
Isabel A. Maia
Isabel A. Maia
Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
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Frank S. Bezerra
Frank S. Bezerra
Laboratory of Experimental Pathophysiology (LAFEx), Department of Biological Sciences (DECBI), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil.
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André Luis Pereira de Albuquerque
André Luis Pereira de Albuquerque
Pneumology Division, Heart Institute, Hospital das Clínicas da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.
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Heitor F. Andrade Jr.
Heitor F. Andrade Jr.
Laboratory of Protozoology, Instituto de Medicina Tropical de Sao Paulo (IMTSP), Universidade de São Paulo, São Paulo, Brazil.
Department of Pathology, Faculty of Medicine, University of São Paulo (FMUSP), São Paulo, Brazil.
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Department of Pathology, Faculty of Medicine, University of São Paulo (FMUSP), São Paulo, Brazil.
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Antonio C. Nicodemo
Antonio C. Nicodemo
Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
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Valdir S. Amato
Valdir S. Amato
Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
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Visceral leishmaniasis (VL) is associated with interstitial pneumonitis according to histology and radiology reports. However, studies to address the functional impact on respiratory function in patients are lacking. We assessed pulmonary function using noninvasive spirometry in a cross-sectional study of hospitalized adult VL patients from Minas Gerais, Brazil, without unrelated lung conditions or acute infections. Lung conditions were graded as normal, restrictive, obstructive, or mixed patterns, according to Brazilian consensus standards for spirometry. To control for regional patterns of lung function, we compared spirometry of patients with regional paired controls. Spirometry detected abnormal lung function in most VL patients (70%, 14/20), usually showing a restrictive pattern, in contrast to regional controls and the standards for normal tests. Alterations in spirometry measurements correlated with hypoalbuminemia, the only laboratory value indicative of severity of parasitic disease. Abnormalities did not correlate with unrelated factors such as smoking or occupation. Clinical data including pulmonary symptoms and duration of therapy were also unrelated to abnormal spirometry findings. We conclude that the severity of VL is correlated with a restrictive pattern of lung function according to spirometry, suggesting that there may be interstitial lung involvement in VL. Further studies should address whether spirometry could serve as an index of disease severity in the management of VL.
Author Notes
Financial support: Heitor F. Andrade Jr. is a fellow from CNPq and FFM. LIMHCFMUSP partially supported this work.
Authors' addresses: Isabel A. Maia, Antonio C. Nicodemo, and Valdir S. Amato, Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, Brazil, E-mails: isabel.aragao@yahoo.com, ac_nicodemo@uol.com.br, and valdirsa@netpoint.com.br. Frank S. Bezerra, Department of Biological Sciences (DECBI), Center of Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Brazil, E-mail: franksbezerra@hotmail.com. André Luis Pereira de Albuquerque, Pneumology Division, Heart Institute, Hospital das Clínicas da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil, E-mail: drean.albuquerque@gmail.com. Heitor F. Andrade Jr., Laboratory of Protozoology, Instituto de Medicina Tropical de Sao Paulo (IMTSP), São Paulo, Brazil, E-mail: hfandrad@usp.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Dejeux P, 2004. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27: 305–318.
-
2.
de Silva AA, Pacheco e Silva Filho Á, Sesso R de C, Esmeraldo R de M, de Oliveira CM, Fernandes PF, de Oliveira RA, de Silva LS, de Carvalho VP, Costa CH, Andrade JX, da Silva DM, Chaves RV, 2015. Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases. BMC Infect Dis 15: 96.
-
3.
Cousins S, 2015. India makes good progress in combating kala-azar. Lancet 385: 1716.
-
4.
Andrade ZA, 1959. Pneumonite intersticial no calazar. Hospital 55: 371–381.
-
5.
Duarte MI, Da Matta VL, Corbett CE, Laurenti MD, Chebabo R, Goto H, 1989. Interstitial pneumonitis in human visceral leishmaniasis. Trans R Soc Trop Med Hyg 83: 73–76.
-
6.
Druzian AF, de Souza AS, de Campos DN, Croda J, Higa MG Jr, Dorval ME, Pompilio MA, de Oliveira PA, Paniago AM, 2015. Risk factors for death from visceral leishmaniasis in an urban area of Brazil. PLoS Negl Trop Dis 9: e0003982.
-
7.
Duarte MI, Laurenti MD, Brandão Nunes VL, Rego Júnior FA, Oshiro ET, Corbett CE, 1986. Interstitial pneumonitis in canine visceral leishmaniasis. Rev Inst Med Trop Sao Paulo 28: 431–436.
-
8.
Tuon FF, Guedes F, Fernandes ER, Pagliari C, Amato VS, Seixas Duarte MI, 2009. In situ immune responses to interstitial pneumonitis in human visceral leishmaniasis. Parasite Immunol 31: 98–103.
-
9.
Silva LC, Castro RS, Figueiredo MM, Michalick MS, Tafuri WL, Tafuri WL, 2013. Canine visceral leishmaniasis as a systemic fibrotic disease. Int J Exp Pathol 94: 133–143.
-
10.
Hayes D Jr, Kraman SS, 2009. The physiologic basis of spirometry. Respir Care 54: 1717–1726.
-
11.
Escobar H, Carver TW Jr, 2011. Pulmonary function testing in young children. Curr Allergy Asthma Rep 11: 473–481.
-
12.
Ramsey KA, Ranganathan S, Park J, Skoric B, Adams AM, Simpson SJ, Robins-Browne RM, Franklin PJ, de Klerk NH, Sly PD, Stick SM, Hall GL, Arest CF, 2014. Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis. Am J Respir Crit Care Med 190: 1111–1116.
-
13.
Pereira CA, 2002. II Consenso de Espirometria. J Pneumol 28: s1–s80.
-
14.
Georgiadou SP, Stefos A, Spanakos G, Skrimpas S, Makaritsis K, Sipsas NV, Dalekos GN, 2015. Current clinical, laboratory and treatment outcome characteristics of visceral leishmaniasis: results from a seven-year retrospective study in Greece. Int J Infect Dis 34: 46–50.
-
15.
Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O'Donnell DE, Aaron SD; CanCOLD Collaborative Research Group, 2015. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax 70: 822–829.
-
16.
Gan WQ, Man SF, Senthilselvan A, Sin DD, 2004. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 59: 574–580.
-
17.
Lunt A, McGhee E, Robinson P, Rees D, Height S, Greenough A, 2016. Lung function, transfusion, pulmonary capillary blood volume and sickle cell disease. Respir Physiol Neurobiol 222: 6–10.
-
18.
Murray HW, 2004. Treatment of visceral leishmaniasis in 2004. Am J Trop Med Hyg 71: 787–794 (Review).
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 17 | 17 | 3 |
| Full Text Views | 292 | 75 | 1 |
| PDF Downloads | 60 | 15 | 0 |