Author:
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1.
Daumerie D, Savioli L, Crompton D, Peters P, 2010. Working to Overcome the Global Impact of Neglected Tropical Diseases: First WHO Report on Neglected Tropical Diseases. Geneva, Switzerland: World Health Organization.
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2.
Calvopina M, Romero D, Castañeda B, Hashiguchi Y, Sugiyama H, 2014. Current status of Paragonimus and paragonimiasis in Ecuador. Mem Inst Oswaldo Cruz 109: 849–855.
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3.
Acha P, Szyfres B, 2003. Paragonimiasis. Zoonosis y Enfermedades Transmisibles Comunes al Hombre y a los Animales: Parasitosis, 3rd edition, Volume 3. Washington, DC: Pan American Health Organization, 158–164.
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4.
Shim YS, Cho SY, Han YC, 1991. Pulmonary paragonimiasis: a Korean perspective. Semin Respir Crit Care Med 12: 35–45.
-
5.
Im JG, Whang HY, Kim WS, Han MC, Shim YS, Cho SY, 1992. Pleuropulmonary paragonimiasis: radiologic findings in 71 patients. Am J Roentgenol 159: 39–43.
-
6.
Zhong HL, Chung HL, He LY, Ho LY, Xu ZB, Hsu CP, Cao WJ, Tsao WC, 1981. Recent progress in studies of Paragonimus and paragonimiasis control in China. Chin Med J (Engl) 94: 483–494.
-
7.
Peñafiel W, Dávalos R, Coloma M, 1981. Paragonimiasis pulmonar. Revisión clínica de 92 casos. Rev Fac Cienc Med 6: 253–261.
-
8.
Singh TS, Mutum SS, Razaque MA, 1986. Pulmonary paragonimiasis: clinical features, diagnosis and treatment of 39 cases in Manipur. Trans R Soc Trop Med Hyg 80: 967–971.
-
9.
Sugiyama H, Singh TS, Rangsiruji A, 2013. Paragonimus. Dongyou L, ed. Molecular Detection of Human Parasitic Pathogens. Boca Raton, FL: CRC Press, 423–436.
-
10.
Díaz G, Calvopina M, Guderian R, Amunárriz M, 1991. Control de la Paragonimiasis en el Ecuador. Boletín Epidemiológico. Programa de Enfermedades Tropicales. Quito, Ecuador: Ministerio de Salud Pública, 1–18.
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11.
Gómez-Seco J, Rodríguez-Guzmán MJ, Rodríguez-Nieto MJ, Gómez-Escolar PF, Presa-Abos T, Fortes-Alen J, 2011. Pulmonary paragonimiasis. Arch Bronconeumol 47: 610–612.
-
12.
Lall M, Sahni AK, Rajput AK, 2013. Pleuropulmonary paragonimiasis: mimicker of tuberculosis. Pathog Glob Health 107: 40–42.
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13.
Ministerio de Salud Pública del Ecuador, 2010. Manual de Normas y Procedimientos para el Control de la Tuberculosis. Quito, Ecuador: Ministerio de Salud Pública, 1–336.
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14.
Kim TS, Han J, Shim SS, Jeon K, Koh WJ, Lee I, Lee KS, Kwon OJ, 2005. Pleuropulmonary paragonimiasis: CT findings in 31 patients. Am J Roentgenol 185: 616–621.
-
15.
Slesak G, Inthalad S, Basy P, Keomanivong D, Phoutsavath O, Khampoui S, Grosrenaud A, Amstutz V, Barennes H, Buisson Y, Odermatt P, 2011. Ziehl-Neelsen staining technique can diagnose paragonimiasis. PLoS Negl Trop Dis 5: 1–8.
-
16.
Consejo Nacional de Salud, 2014. Cuadro Nacional de Medicamentos Básicos y Registro Terapéutico, 9th edition. Quito, Ecuador: Ministerio de Salud Pública, 586.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 55 | 55 | 10 |
| Full Text Views | 473 | 118 | 1 |
| PDF Downloads | 222 | 38 | 0 |
Severe Pleuropulmonary Paragonimiasis Caused by Paragonimus mexicanus Treated as Tuberculosis in Ecuador
Manuel Calvopina
Manuel Calvopina
Unidad de Parasitología Molecular y Medicina Tropical, Carrera de Medicina, Universidad De Las Américas (UDLA), Quito, Ecuador.
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Daniel Romero-Alvarez
Daniel Romero-Alvarez
Unidad de Parasitología Molecular y Medicina Tropical, Carrera de Medicina, Universidad De Las Américas (UDLA), Quito, Ecuador.
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Rubén Macias
Rubén Macias
Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador.
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Hiromu Sugiyama
Hiromu Sugiyama
Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.
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A 30-year-old male, from a subtropical region of Ecuador, was hospitalized with a 5-year history of persistent cough with rusty brown sputum, chest pain, and progressive dyspnea. The patient underwent thoracic surgery 3 years ago for pleural effusion and subsequently received a 9-month regimen treatment of tuberculosis. However, there was no clinical resolution and symptoms became progressively worse. A chest radiograph and computerized tomography scan showed several small nodules in both lungs. Eggs of Paragonimus spp. were observed in sputum smears, but the smears were negative for acid-fast bacilli. Molecular characterization of eggs by the internal transcribed spacer-2 regions identified them as Paragonimus mexicanus. The patient was treated with praziquantel and tested negative parasitologically for 12 months. There was clinical resolution of the cough and expectoration, but dyspnea and chest pain persisted.
Author Notes
Financial support: This study was supported in part by the Japan Society for the Promotion of Science, JSPS (KAKENHI: Grant No. 25305011) and by grants for Research on Emerging and Re-emerging Infectious Diseases (H26-Shinko-ippan-009) from the Ministry of Health, Labor and Welfare of Japan.
Authors' addresses: Manuel Calvopina and Daniel Romero, Unidad de Parasitología Molecular y Medicina Tropical, Carrera de Medicina, Universidad De Las Américas (UDLA), Quito, Ecuador, E-mails: manuelcalvopina@gmail.com and vacdaro@hotmail.com. Ruben Macias, Hospital Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social (IESS), Quito, Ecuador, E-mail: rubenmaciasj@hotmail.com. Hiromu Sugiyama, Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan, E-mail: hsugi@nih.go.jp.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Daumerie D, Savioli L, Crompton D, Peters P, 2010. Working to Overcome the Global Impact of Neglected Tropical Diseases: First WHO Report on Neglected Tropical Diseases. Geneva, Switzerland: World Health Organization.
-
2.
Calvopina M, Romero D, Castañeda B, Hashiguchi Y, Sugiyama H, 2014. Current status of Paragonimus and paragonimiasis in Ecuador. Mem Inst Oswaldo Cruz 109: 849–855.
-
3.
Acha P, Szyfres B, 2003. Paragonimiasis. Zoonosis y Enfermedades Transmisibles Comunes al Hombre y a los Animales: Parasitosis, 3rd edition, Volume 3. Washington, DC: Pan American Health Organization, 158–164.
-
4.
Shim YS, Cho SY, Han YC, 1991. Pulmonary paragonimiasis: a Korean perspective. Semin Respir Crit Care Med 12: 35–45.
-
5.
Im JG, Whang HY, Kim WS, Han MC, Shim YS, Cho SY, 1992. Pleuropulmonary paragonimiasis: radiologic findings in 71 patients. Am J Roentgenol 159: 39–43.
-
6.
Zhong HL, Chung HL, He LY, Ho LY, Xu ZB, Hsu CP, Cao WJ, Tsao WC, 1981. Recent progress in studies of Paragonimus and paragonimiasis control in China. Chin Med J (Engl) 94: 483–494.
-
7.
Peñafiel W, Dávalos R, Coloma M, 1981. Paragonimiasis pulmonar. Revisión clínica de 92 casos. Rev Fac Cienc Med 6: 253–261.
-
8.
Singh TS, Mutum SS, Razaque MA, 1986. Pulmonary paragonimiasis: clinical features, diagnosis and treatment of 39 cases in Manipur. Trans R Soc Trop Med Hyg 80: 967–971.
-
9.
Sugiyama H, Singh TS, Rangsiruji A, 2013. Paragonimus. Dongyou L, ed. Molecular Detection of Human Parasitic Pathogens. Boca Raton, FL: CRC Press, 423–436.
-
10.
Díaz G, Calvopina M, Guderian R, Amunárriz M, 1991. Control de la Paragonimiasis en el Ecuador. Boletín Epidemiológico. Programa de Enfermedades Tropicales. Quito, Ecuador: Ministerio de Salud Pública, 1–18.
-
11.
Gómez-Seco J, Rodríguez-Guzmán MJ, Rodríguez-Nieto MJ, Gómez-Escolar PF, Presa-Abos T, Fortes-Alen J, 2011. Pulmonary paragonimiasis. Arch Bronconeumol 47: 610–612.
-
12.
Lall M, Sahni AK, Rajput AK, 2013. Pleuropulmonary paragonimiasis: mimicker of tuberculosis. Pathog Glob Health 107: 40–42.
-
13.
Ministerio de Salud Pública del Ecuador, 2010. Manual de Normas y Procedimientos para el Control de la Tuberculosis. Quito, Ecuador: Ministerio de Salud Pública, 1–336.
-
14.
Kim TS, Han J, Shim SS, Jeon K, Koh WJ, Lee I, Lee KS, Kwon OJ, 2005. Pleuropulmonary paragonimiasis: CT findings in 31 patients. Am J Roentgenol 185: 616–621.
-
15.
Slesak G, Inthalad S, Basy P, Keomanivong D, Phoutsavath O, Khampoui S, Grosrenaud A, Amstutz V, Barennes H, Buisson Y, Odermatt P, 2011. Ziehl-Neelsen staining technique can diagnose paragonimiasis. PLoS Negl Trop Dis 5: 1–8.
-
16.
Consejo Nacional de Salud, 2014. Cuadro Nacional de Medicamentos Básicos y Registro Terapéutico, 9th edition. Quito, Ecuador: Ministerio de Salud Pública, 586.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 55 | 55 | 10 |
| Full Text Views | 473 | 118 | 1 |
| PDF Downloads | 222 | 38 | 0 |