Serological Responses to Filarial Antigens in Malian Children Attending Elementary Schools

Delynn M. Moss Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

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Anna N. Chard Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.

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Victoria Trinies Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.

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Seydou Doumbia Faculty of Medicine and Odontostomatology, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

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Matthew C. Freeman Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.

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Patrick J. Lammie Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

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Dried blood spots (DBS) were collected from 805 children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and the regional capital of Bamako in Mali as part of an evaluation of a school health intervention. Eluted immunoglobulin (Ig) G from the DBS was assessed by a multiplex bead assay (MBA) for two filariasis antigens, Wuchereria bancrofti, Wb123, and Brugia malayi, Bm14, to determine the effectiveness of mass drug administration (MDA) programs to eliminate lymphatic filariasis (LF). The prevalence of positive IgG responses in the children to each antigen was less than 1%, indicating effectiveness of the MDA against LF. The MBA is an excellent serological platform that provides cost-effective opportunities to evaluate public health activities beyond the survey targets.

Author Notes

* Address correspondence to Delynn M. Moss, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Building 23, Room 10-107, Atlanta, GA 30329. E-mail: dmm3@cdc.gov

Financial support: Funding for this study was provided by the Dubai Cares Foundation.

Authors' addresses: Delynn M. Moss, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: dmm3@cdc.gov. Anna N. Chard, Victoria Trinies, and Matthew C. Freeman, Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, E-mails: achard@emory.edu, vtrinies@gmail.com, and mcfreem@emory.edu. Seydou Doumbia, Faculty of Medicine and Odontostomatology, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali, E-mail: sdoumbi@icermali.org. Patrick J. Lammie, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: pjl1@cdc.gov.

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