Sclerosing Orbital Inflammation Caused by Leishmania braziliensis

Antonio Augusto V. Cruz Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Antonio Augusto V. Cruz in
Current site
Google Scholar
PubMed Close
,
Eliza V. C. Alves-Ferreira Department of Cell and Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Eliza V. C. Alves-Ferreira in
Current site
Google Scholar
PubMed Close
,
Gherusa Milbratz-Moré Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Gherusa Milbratz-Moré in
Current site
Google Scholar
PubMed Close
,
Fernando Chahud Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Fernando Chahud in
Current site
Google Scholar
PubMed Close
,
Patricia C. Ruy Department of Cell and Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Patricia C. Ruy in
Current site
Google Scholar
PubMed Close
,
Maria Irma Seixas Duarte Department of Pathology, School of Medicine of University of São Paulo, Sao Paulo, Brazil.

Search for other papers by Maria Irma Seixas Duarte in
Current site
Google Scholar
PubMed Close
, and
Angela Kaysel Cruz Department of Cell and Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Search for other papers by Angela Kaysel Cruz in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.16-0389
Volume/Issue:
Volume 96: Issue 1
Page(s):
197–199
Restricted access
Get Permissions

Orbital biopsy of nonspecific orbital inflammation, commonly referred to as “orbital pseudotumor,” typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of Leishmania braziliensis and DNA from the parasite.

Author Notes

* Address correspondence to Angela Kaysel Cruz, Departamento de Biologia Celular e Molecular, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de Sao Paulo (USP), Av Bandeirantes, 3900, Predio Central, Sao Paulo, Brazil, E-mail: akcruz@fmrp.usp.br or Antonio Augusto V. Cruz, Departamento de Oftalmologia, Hospital das Clínicas-Campus, Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Av Bandeirantes, 3900, Sao Paulo, Brazil, E-mail: aavecruz.fmrp@gmail.com.

Authors' addresses: Antonio Augusto V. Cruz and Gherusa Milbratz-Moré, Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, E-mails: aavecruz.fmrp@gmail.com and gherusa1983@yahoo.com.br. Eliza V. C. Alves-Ferreira, Patricia C. Ruy, and Angela Kaysel Cruz, Department of Cell and Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, E-mails: eliza_carneiro@yahoo.com.br, patriciaruy@usp.br, and akcruz@fmrp.usp.br. Fernando Chahud, Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, E-mail: chahud@fmrp.usp.br. Maria Irma Seixas Duarte, School of Medicine of University of São Paulo, Sao Paulo, Brazil, E-mail: miduarte@usp.br.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2017
Received:
16 May 2016
|
Accepted:
11 Sep 2016
|
Published Online:
11 Jan 2017
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
  • 1.

    Grove AS Jr, Weber AL, 2013. Orbital pseudotumor: historical origin and modern relevance. Ophthal Plast Reconstr Surg 29: 341–346.

  • 2.

    Mombaerts I, Goldschmeding R, Schlingemann RO, Koornneef L, 1996. What is orbital pseudotumor? Surv Ophthalmol 41: 66–78.

  • 3.

    Gibson LJ, McCann SH, Brewster S, Barker DC, 2002. A kinetoplast DNA minicircle probe (B18) specific for the Leishmania subgenus Viannia. Trans R Soc Trop Med Hyg 96 (Suppl 1): S71–S73.

    • Search Google Scholar
    • Export Citation
  • 4.

    de Lima AC, Zampieri RA, Tomokane TY, Laurenti MD, Silveira FT, Corbett CE, Floeter-Winter LM, Gomes CM, 2011. Leishmania sp. identification by PCR associated with sequencing of target SSU rDNA in paraffin-embedded skin samples stored for more than 30 years. Parasitol Res 108: 1525–1531.

    • Search Google Scholar
    • Export Citation
  • 5.

    Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, 1990. Basic local alignment search tool. J Mol Biol 215: 403–410.

  • 6.

    Harris GJ, 2006. Idiopathic orbital inflammation: a pathogenetic construct and treatment strategy: the 2005 ASOPRS Foundation Lecture. Ophthal Plast Reconstr Surg 22: 79–86.

    • Search Google Scholar
    • Export Citation
  • 7.

    David CV, Craft N, 2009. Cutaneous and mucocutaneous leishmaniasis. Dermatol Ther (Heidelb) 22: 491–502.

  • 8.

    Alves-Ferreira EV, Toledo JS, De Oliveira AH, Ferreira TR, Ruy PC, Pinzan CF, Santos RF, Boaventura V, Rojo D, López-Gonzálvez Á, Rosa JC, Barbas C, Barral-Netto M, Barral A, Cruz AK, 2015. Differential gene expression and infection profiles of cutaneous and mucosal Leishmania braziliensis isolates from the same patient. PLoS Negl Trop Dis 9: e0004018.

    • Search Google Scholar
    • Export Citation
  • 9.

    Huna-Baron R, Warren FA, Miller W, Jacobs J, Green J, Kupersmith MJ, 2000. Mucosal leishmaniasis presenting as sinusitis and optic neuropathy. Arch Ophthalmol 118: 852–854.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 16 16 6
Full Text Views 279 80 1
PDF Downloads 123 18 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save