Congenital Plasmodium falciparum Malaria in Washington, DC

Melissa Del Castillo Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, District of Columbia.
Office of Vaccines Research and Review, Food and Drug Administration, Silver Spring, Maryland.

Search for other papers by Melissa Del Castillo in
Current site
Google Scholar
PubMed
Close
,
Ann Marie Szymanski Division of General Pediatrics, Children's National Medical Center, Washington, District of Columbia.

Search for other papers by Ann Marie Szymanski in
Current site
Google Scholar
PubMed
Close
,
Ariella Slovin Division of General Pediatrics, Children's National Medical Center, Washington, District of Columbia.

Search for other papers by Ariella Slovin in
Current site
Google Scholar
PubMed
Close
,
Edward C. C. Wong Division of Laboratory Medicine, Children's National Medical Center, Washington, District of Columbia.
Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Department of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

Search for other papers by Edward C. C. Wong in
Current site
Google Scholar
PubMed
Close
, and
Roberta L. DeBiasi Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, District of Columbia.
Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

Search for other papers by Roberta L. DeBiasi in
Current site
Google Scholar
PubMed
Close
Restricted access

Congenital malaria is rare in the United States, but is an important diagnosis to consider when evaluating febrile infants. Herein, we describe a case of congenital Plasmodium falciparum malaria in a 2-week-old infant born in the United States to a mother who had emigrated from Nigeria 3 months before delivery.

Author Notes

* Address correspondence to Roberta L. DeBiasi, Division of Pediatric Infectious Diseases, Children's National Medical Center, West Wing 3.5, Suite 100, Washington, DC 20010. E-mail: rdebiasi@childrensnational.org

Authors' addresses: Melissa Del Castillo, Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC, and Office of Vaccines Research and Review, Food and Drug Administration, Silver Spring, MD, E-mail: mdelcast@cnmc.org. Ann Marie Szymanski and Ariella Slovin, Division of General Pediatrics, Children's National Medical Center, Washington, DC, E-mails: aszymans@cnmc.org and aslovin@cnmc.org. Edward C. C. Wong, Division of Laboratory Medicine, Children's National Medical Center, Washington, DC, E-mail: ewong@cnmc.org. Roberta L. DeBiasi, Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, and Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC, E-mail: rdebiasi@cnmc.org.

  • 1.

    Menendez C, Mayor A, 2007. Congenital malaria: the least known consequence of malaria in pregnancy. Semin Fetal Neonatal Med 12: 207213.

    • Search Google Scholar
    • Export Citation
  • 2.

    Lesko CR, Arguin PM, Newman RD, 2007. Congenital malaria in the United States: a review of cases from 1966 to 2005. Arch Pediatr Adolesc Med 161: 10621067.

    • Search Google Scholar
    • Export Citation
  • 3.

    Vottier G, Arsac M, Farnoux C, Mariani-Kurkdjian P, Baud O, Aujard Y, 2008. Congenital malaria in neonates: two case reports and review of the literature. Acta Paediatr 97: 500512.

    • Search Google Scholar
    • Export Citation
  • 4.

    De Silva DH, Mendis KN, Premaratne UN, Jayatilleke SM, Soyza PE, 1982. Congenital malaria due to Plasmodium vivax: a case report from Sri Lanka. Trans R Soc Trop Med Hyg 76: 3335.

    • Search Google Scholar
    • Export Citation
  • 5.

    Osungbade KO, Oladunjoye OO, 2012. Prevention of congenital transmission of malaria in sub-Saharan African countries: challenges and implications for health system strengthening. J Trop Med 2012: 648456.

    • Search Google Scholar
    • Export Citation
  • 6.

    Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW, 2012. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Lancet Infect Dis 12: 942949.

    • Search Google Scholar
    • Export Citation
  • 7.

    Menendez C, Bardaji A, Sigauque B, Sanz S, Aponte JJ, Mabunda S, Alonso PL, 2010. Malaria prevention with IPTp during pregnancy reduces neonatal mortality. PLoS One 5: e9438.

    • Search Google Scholar
    • Export Citation
  • 8.

    Riley EM, Wagner GE, Akanmori BD, Koram KA, 2001. Do maternally acquired antibodies protect infants from malaria infection? Parasite Immunol 23: 5159.

    • Search Google Scholar
    • Export Citation
  • 9.

    Riley EM, Wagner GE, Ofori MF, Wheeler JG, Akanmori BD, Tetteh K, McGuinness D, Bennett S, Nkrumah FK, Anders RF, Koram KA, 2000. Lack of association between maternal antibody and protection of African infants from malaria infection. Infect Immun 68: 58565863.

    • Search Google Scholar
    • Export Citation
  • 10.

    Amaratunga C, Lopera-Mesa TM, Brittain NJ, Cholera R, Arie T, Fujioka H, Keefer JR, Fairhurts RM, 2011. A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. PLoS One 6: e14798.

    • Search Google Scholar
    • Export Citation
  • 11.

    Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE, 2003. Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 349: 11571167.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 30 30 4
Full Text Views 286 74 1
PDF Downloads 66 17 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save