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Reference Manager
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1.
O'Connell EM, Nutman TB, 2015. Eosinophilia in infectious diseases. Immunol Allergy Clin North Am 35: 493–522.
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2.
Garcia HH, Nash TE, Del Brutto OH, 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
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4.
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Del Brutto OH, 2012. Diagnostic criteria for neurocysticercosis, revisited. Pathog Glob Health 106: 299–304.
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Schulte C, Krebs B, Jelinek T, Nothdurft HD, von Sonnenburg F, Loscher T, 2002. Diagnostic significance of blood eosinophilia in returning travelers. Clin Infect Dis 34: 407–411.
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7.
Nutman TB, Ottesen EA, Ieng S, Samuels J, Kimball E, Lutkoski M, Zierdt WS, Gam A, Neva FA, 1987. Eosinophilia in southeast Asian refugees: evaluation at a referral center. J Infect Dis 155: 309–313.
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Gill GV, Bailey JW, 1989. Eosinophilia as a marker for chronic strongyloidiasis—use of a serum ELISA test to detect asymptomatic cases. Ann Trop Med Parasitol 83: 249–252.
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9.
Buonfrate D, Angheben A, Gobbi F, Munoz J, Requena-Mendez A, Gotuzzo E, Mena MA, Bisoffi Z, 2012. Imported strongyloidiasis: epidemiology, presentations, and treatment. Curr Infect Dis Rep 14: 256–262.
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10.
Repetto SA, Duran PA, Lasala MB, Gonzalez-Cappa SM, 2010. High rate of strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections. Am J Trop Med Hyg 82: 1088–1093.
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Trelles JO, Rocca ED, 1952. Thirty-five verified cases of cysticercosis of the brain. Trans Am Neurol Assoc 56: 263–267.
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Wadia N, Desai S, Bhatt M, 1988. Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel. Brain 111: 597–614.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 24 | 24 | 2 |
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The Lack of Association of Eosinophilia and Neurocysticercosis at Clinical Presentation: A Retrospective Analysis of Cases Seen at the National Institutes of Health, 1985–2015
JeanAnne M. Ware
JeanAnne M. Ware
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
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Theodore E. Nash
Theodore E. Nash
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
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Abstract
Eosinophilia is a common laboratory finding in helminth infections but whether it is suggestive of neurocysticercosis (NCC) is controversial and inadequately studied. We determined the presence of eosinophilia (≥ 500 eosinophils/mm3) at clinical presentation in 72 patients with a proven or probable diagnosis of NCC and who had not received corticosteroids within 2 weeks of evaluation and complete blood count. Only two persons whose last possible endemic exposures to NCC were 7 and 6 years earlier had eosinophilia of 500 eosinophils/mm3 and both had a positive antibody serology to strongyloidiasis. In the one subject where a follow-up assessment was possible, the eosinophilia resolved. The likely cause for eosinophilia in both was strongyloidiasis. Therefore, none of the subjects with newly diagnosed NCC had significant eosinophilia. Eosinophilia in newly diagnosed symptomatic NCC subjects who had remote exposure is unusual and should prompt a search for another process or infection.
Author Notes
Financial support: This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
Authors' addresses: JeanAnne M. Ware and Theodore E. Nash, Laboratory of Parasitic Diseases, National Institutes of Health Clinical Center, Bethesda, MD, E-mails: warejm@niaid.nih.gov and tnash@niaid.nih.gov.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
O'Connell EM, Nutman TB, 2015. Eosinophilia in infectious diseases. Immunol Allergy Clin North Am 35: 493–522.
-
2.
Garcia HH, Nash TE, Del Brutto OH, 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
3.
Dixon HBF, Lipscomb FM, 1961. Cysticercosis: An Analysis and Follow Up of 450 Cases. Medical Council Special Report Series, No 299. London, United Kingdom: Her Majesty's Stationary Office, 1–58.
-
4.
Loo L, Braude A, 1982. Cerebral cysticercosis in San Diego. A report of 23 cases and a review of the literature. Medicine (Baltimore) 61: 341–359.
-
5.
Del Brutto OH, 2012. Diagnostic criteria for neurocysticercosis, revisited. Pathog Glob Health 106: 299–304.
-
6.
Schulte C, Krebs B, Jelinek T, Nothdurft HD, von Sonnenburg F, Loscher T, 2002. Diagnostic significance of blood eosinophilia in returning travelers. Clin Infect Dis 34: 407–411.
-
7.
Nutman TB, Ottesen EA, Ieng S, Samuels J, Kimball E, Lutkoski M, Zierdt WS, Gam A, Neva FA, 1987. Eosinophilia in southeast Asian refugees: evaluation at a referral center. J Infect Dis 155: 309–313.
-
8.
Gill GV, Bailey JW, 1989. Eosinophilia as a marker for chronic strongyloidiasis—use of a serum ELISA test to detect asymptomatic cases. Ann Trop Med Parasitol 83: 249–252.
-
9.
Buonfrate D, Angheben A, Gobbi F, Munoz J, Requena-Mendez A, Gotuzzo E, Mena MA, Bisoffi Z, 2012. Imported strongyloidiasis: epidemiology, presentations, and treatment. Curr Infect Dis Rep 14: 256–262.
-
10.
Repetto SA, Duran PA, Lasala MB, Gonzalez-Cappa SM, 2010. High rate of strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections. Am J Trop Med Hyg 82: 1088–1093.
-
11.
Neva FA, Brown HW, 1994. Basic Clinical Parasitology. Norwalk, CT: Appleton and Lange.
-
12.
Trelles JO, Rocca ED, 1952. Thirty-five verified cases of cysticercosis of the brain. Trans Am Neurol Assoc 56: 263–267.
-
13.
Hiatt RA, Sotomayor ZR, Sanchez G, Zambrana M, Knight WB, 1979. Factors in the pathogenesis of acute schistosomiasis mansoni. J Infect Dis 139: 659–666.
-
14.
Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE, 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 1–16.
-
15.
Wadia N, Desai S, Bhatt M, 1988. Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel. Brain 111: 597–614.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 24 | 24 | 2 |
| Full Text Views | 257 | 72 | 0 |
| PDF Downloads | 77 | 23 | 0 |