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Treatment of Schistosomiasis in a Patient Allergic to Praziquantel: A Desensitization and Treatment Protocol

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  • 1 Hospital for Tropical Diseases, London, United Kingdom.
  • | 2 Royal National Throat, Nose and Ear Hospital, University College London Hospital, London, United Kingdom.
  • | 3 Enys Road Surgery, Eastbourne, United Kingdom.
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Praziquantel is the mainstay of treatment of Schistosomiasis, which affects at least 262 million people worldwide. It is also used in the treatment of other trematode as well as cestode infections, with few safe and effective alternatives. It is generally well tolerated and allergic reactions are rare. In this report, we present a case of schistosomiasis with a history of a hypersensitivity reaction to praziquantel. Skin-prick and intradermal testing were performed, followed by treatment through rapid desensitization. This protocol may be of value to those patients requiring praziquantel treatment with a history of IgE-mediated allergy to the drug.

Author Notes

* Address correspondence to Joanna Lukawska, Royal National Throat, Nose and Ear Hospital, 330 Grays Inn Road, London WC1X 8DA, United Kingdom. E-mail: joanna.lukawska@uclh.nhs.uk

Authors' addresses: Trupti A. Patel and Robin L. Bailey, Hospital for Tropical Diseases, London, United Kingdom, E-mails: truptipatel1@nhs.net and robin.bailey@lshtm.ac.uk. Joanna Lukawska, Royal National Throat, Nose and Ear Hospital, University College London Hospital, London, United Kingdom, E-mail: joanna.lukawska@uclh.nhs.uk. Jennifer Rowe, Enys Road Surgery, Eastbourne, United Kingdom, E-mail: drjen2005@hotmail.com.