ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Mega JD, Galdos-Cardenas G, Gilman RH, 2012. Tapeworm infections. Magill AS, Ryan ET, Hill DR, Solomon T, eds. Hunter's Tropical Medicine and Emerging Infectious Diseases, 9th edition. Liverpool, United Kingdom: Saunders Elsevier.
-
2.
Arora HS, Ang JY, 2015. Hymenolepiasis. Medscape. Available at: http://emedicine.medscape.com/article/998498-overview. Accessed December 5, 2015.
-
3.
Center for Disease Control and Prevention, 2012. Hymenolepiasis FAQs. Available at: http://www.cdc.gov/parasites/hymenolepis/faqs.html. Accessed December 5, 2015.
-
4.
Mirdha B, 2002. Hymenolepis nana: a common cause of paediatric diarrhoea in urban slum dwellers in India. J Trop Pediatr 48: 331–334.
-
5.
Abrar UI, Haq K, Gul NA, Hammad HM, Bibi Y, Mohsan J, 2015. Prevalence of Giardia intestinalis and Hymenolepis nana in Afghan refugee population in Mianwali District, Pakistan. Afr Health Sci 15: 394–400.
-
6.
Maco-Flores V, Marcos-Raymundo L, Terashima-Iwashita A, Samalvides-Cuba F, Miranda-Sanchez E, Espinoza-Babilon J, Gotuzzo-Herencia J, 2002. Fas-2 ELISA and the rapid sedimentation technique modified by Lumbreras for Fasciola hepatica infection diagnosis. Rev Med Hered 13: 49–57. Available at: http://www.scielo.org.pe/pdf/rmh/v13n2/v13n2ao3.pdf. Accessed November 22, 2015.
-
7.
Jagota SC, 1986. Albendazole, a broad-spectrum anthelmintic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients. Clin Ther 8: 226–231.
-
8.
Horton J, 2000. Albendazole: a review of anthelminthic efficacy and safety in humans. Parasitology 121 (Suppl): S113–S132.
-
9.
Soares Magalhaes RJ, Fancony C, Gamboa D, Langa AJ, Sousa-Figueiredo JC, Clements ACA, Vaz Nery S, 2013. Extending helminth control beyond STH and schistosomiasis: the case of human hymenolepiasis. PLoS Negl Trop Dis 7: e2321.
-
10.
Machicado JD, Marcos LA, Tello R, Canales M, Terashima A, Gotuzzo E, 2012. Diagnosis of soil-transmitted helminthiasis in an Amazonic community of Peru using multiple diagnostic techniques. Trans Roy Soc Trop Med 106: 333–339.
-
11.
Tefera E, Mohammed J, Mitiku H, 2015. Intestinal helminth infections among elementary students in Babile town, eastern Ethiopia. Pan Afr Med J 20: 50.
-
12.
Romero-Cabello R, Godinez-Hana L, Gutierrez-Quiroz M, 1991. Clinical aspects of hymenolepiasis in pediatrics. Bol Med Hosp Infant Mex 48: 101–105 [Spanish].
-
13.
Suarez-Hernandez M, Bonet-Couce E, Diaz-Gonzalez M, Ocampo-Ruiz I, Vidal-Garcia I, 1998. Epidemiology study on Hymenolepsis nana infection in Ciego de Avila Province, Cuba. Bol Chil Parasitol 53: 31–34 [Spanish].
-
14.
Abdel Hamid M, Eljack I, Osman M, Elaagip A, Muneer M, 2015. The prevalence of Hymenolepis nana among preschool children of displacement communities in Khartoum state, Sudan: a cross-sectional study. Travel Med Infect Dis 13: 172–177.
-
15.
Willcocks B, Mcauliffe G, Baird R, 2015. Dwarf tapeworm (Hymenolepis nana): characteristics in the northern territory 2002–2013. J Paediatr Child Health 51: 982–987.
-
16.
Khalil H, El Shimi S, Sarwat M, Fawzy A, El Shimi A, 1991. Recent study of Hymenolepsis nana infection in Egyptian children. J Egypt Soc Parasitol 21: 293–300.
-
17.
Stephenson LS, Latham MC, Adams EJ, Kinoti SN, Pertet A, 1993. Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice-yearly treatment with albendazole. J Nutr 123: 656–665.
-
18.
Stephenson LS, Kinoti SN, Latham MC, Kurz KM, Kyobe J, 1989. Single dose metrifonate or praziquantel treatment in Kenyan children. I. Effects on Schistosoma haematobium, hookworm, hemoglobin levels, splenomegaly, and hepatomegaly. Am J Trop Med Hyg 41: 436–444.
-
19.
Chero J, Saito M, Bustos J, Blanco E, Gonzalvez G, Garcia HH, Cysticercosis Working Group Peru, 2006. Hymenolepis nana infection: symptoms and response to nitazoxanide in field conditions. Trans R Soc Trop Med Hyg 101: 203–205.
-
20.
Muniz-Junqueira MI, Queiróz EF, 2002. Relationship between protein-energy malnutrition, vitamin A, and parasitoses in children living in Brasília. Rev Soc Bras Med Trop 35: 133–142.
-
21.
Oliveira D, Ferreira FS, Atouguia J, Fortes F, Guerra A, 2015. Infections by intestinal parasites, stunting, and anemia in school-aged children in southern Angola. PLoS One 10: e0137327.
-
22.
Liu C, Luo R, Yi H, Zhang L, Li S, Bai Y, Medina A, Rozelle S, Smith S, Wang G, Wang J, 2015. Soil-transmitted helminths in southwestern China: a cross-sectional study of links to cognitive ability, nutrition, and school performance among children. PLoS Negl Trop Dis 9: e0003877.
-
23.
Echazú A, Bonanno D, Juarez M, Cajal SP, Heredia V, Caropresi S, Cimino RO, Caro N, Vargas PA, Paredes G, Krolewiecki AJ, 2015. Effect of poor access to water and sanitation as risk factors for soil-transmitted helminth infection: selectiveness by the infective route. PLoS Negl Trop Dis 9: e0004111.
-
24.
Strunz EC, Addiss DG, Stocks ME, Ogden S, Utzinger J, Freeman MC, 2014. Water, sanitation, hygiene, and soil-transmitted helminth infection: a systematic review and meta-analysis. PLoS Med 11: e1001620.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 924 | 655 | 24 |
| Full Text Views | 925 | 7 | 0 |
| PDF Downloads | 505 | 8 | 0 |
Hymenolepis nana Impact Among Children in the Highlands of Cusco, Peru: An Emerging Neglected Parasite Infection
Miguel M. Cabada
Miguel M. Cabada
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Universidad Peruana Cayetano Heredia–University of Texas Medical Branch Collaborative Research Center—Cusco, Cusco, Peru.
Search for other papers by Miguel M. Cabada in
Current site
Google Scholar
PubMed
Universidad Peruana Cayetano Heredia–University of Texas Medical Branch Collaborative Research Center—Cusco, Cusco, Peru.
Search for other papers by Miguel M. Cabada in
Current site
Google Scholar
PubMed
Maria Luisa Morales
Maria Luisa Morales
Universidad Peruana Cayetano Heredia–University of Texas Medical Branch Collaborative Research Center—Cusco, Cusco, Peru.
Search for other papers by Maria Luisa Morales in
Current site
Google Scholar
PubMed
Search for other papers by Maria Luisa Morales in
Current site
Google Scholar
PubMed
Martha Lopez
Martha Lopez
Universidad Peruana Cayetano Heredia–University of Texas Medical Branch Collaborative Research Center—Cusco, Cusco, Peru.
Search for other papers by Martha Lopez in
Current site
Google Scholar
PubMed
Search for other papers by Martha Lopez in
Current site
Google Scholar
PubMed
Spencer T. Reynolds
Spencer T. Reynolds
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Search for other papers by Spencer T. Reynolds in
Current site
Google Scholar
PubMed
Search for other papers by Spencer T. Reynolds in
Current site
Google Scholar
PubMed
Elizabeth C. Vilchez
Elizabeth C. Vilchez
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Search for other papers by Elizabeth C. Vilchez in
Current site
Google Scholar
PubMed
Search for other papers by Elizabeth C. Vilchez in
Current site
Google Scholar
PubMed
Andres G. Lescano
Andres G. Lescano
School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Search for other papers by Andres G. Lescano in
Current site
Google Scholar
PubMed
Search for other papers by Andres G. Lescano in
Current site
Google Scholar
PubMed
Eduardo Gotuzzo
Eduardo Gotuzzo
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Search for other papers by Eduardo Gotuzzo in
Current site
Google Scholar
PubMed
Search for other papers by Eduardo Gotuzzo in
Current site
Google Scholar
PubMed
Hector Hugo Garcia
Hector Hugo Garcia
Departamento de Microbiologia, Universidad Peruana Cayetano Heredia, Lima, Peru.
Search for other papers by Hector Hugo Garcia in
Current site
Google Scholar
PubMed
Search for other papers by Hector Hugo Garcia in
Current site
Google Scholar
PubMed
Clinton A. White Jr.
Clinton A. White Jr.
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Search for other papers by Clinton A. White Jr. in
Current site
Google Scholar
PubMed
Search for other papers by Clinton A. White Jr. in
Current site
Google Scholar
PubMed
Hymenolepis nana is the most common cestode infection in the world. However, limited information is available regarding its impact on affected populations. We studied the epidemiology and symptoms associated with hymenolepiasis among children 3–16 years old in 16 rural communities of the highlands of the Cusco region in Peru. Information on demographics, socioeconomic status, symptoms as reported by parents, and parasitological testing was obtained from the database of an ongoing Fasciola hepatica epidemiologic study. A total of 1,230 children were included in the study. Forty-five percent were infected with at least one pathogenic intestinal parasite. Giardia spp. (22.9%) was the most common, followed by Hymenolepis (17.4%), Fasciola (14.1%), Ascaris lumbricoides (6.1%), and Strongyloides stercoralis (2%). The prevalence of Hymenolepis infection varied by community, by other parasitic infections, and by socioeconomic status. However, only years of education of the mother, use of well water, and age less than 10 years were associated with Hymenolepis infection in the multivariate analysis. Hymenolepis nana infection was associated with diarrhea, jaundice, headaches, fever, and fatigue. Children with > 500 eggs/g of stool were more likely to have symptoms of weight loss, jaundice, diarrhea, and fever. Hymenolepis nana infection and age were the only factors retained in the multivariate analysis modeling diarrhea. Hymenolepiasis is a common gastrointestinal helminth in the Cusco region and is associated with significant morbidity in children in rural communities. The impact caused by the emergence of Hymenolepis as a prevalent intestinal parasite deserves closer scrutiny.
Author Notes
Financial support: This study was funded by the National Institute for Allergy and Infectious Diseases at the National Institutes of Health Grant 1R01AI104820-01. AGL is sponsored by the training grant 2D43 TW007393 awarded by the Fogarty International Center of the US National Institutes of Health.
Authors' addresses: Miguel M. Cabada, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, and Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: micabada@utmb.edu. Maria Luisa Morales and Martha Lopez, Universidad Peruana Cayetano Heredia–University of Texas Medical Branch Collaborative Research Center—Cusco, Cusco, Peru, E-mails: malu.morales.fernandez@gmail.com and martlop2000@gmail.com. Spencer T. Reynolds and Elizabeth C. Vilchez, School of Medicine, University of Texas Medical Branch at Galveston, Galveston, TX, E-mails: streynol@utmb.edu and ecvilche@utmb.edu. Andres G. Lescano, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: andres.lescano.g@upch.pe. Eduardo Gotuzzo, Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: eduardo.gotuzzo@upch.pe. Hector Hugo Garcia, Departamento de Microbiologia, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: hgarcia1@jhu.edu. Clinton A. White Jr., Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, E-mail: acwhite@utmb.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Mega JD, Galdos-Cardenas G, Gilman RH, 2012. Tapeworm infections. Magill AS, Ryan ET, Hill DR, Solomon T, eds. Hunter's Tropical Medicine and Emerging Infectious Diseases, 9th edition. Liverpool, United Kingdom: Saunders Elsevier.
-
2.
Arora HS, Ang JY, 2015. Hymenolepiasis. Medscape. Available at: http://emedicine.medscape.com/article/998498-overview. Accessed December 5, 2015.
-
3.
Center for Disease Control and Prevention, 2012. Hymenolepiasis FAQs. Available at: http://www.cdc.gov/parasites/hymenolepis/faqs.html. Accessed December 5, 2015.
-
4.
Mirdha B, 2002. Hymenolepis nana: a common cause of paediatric diarrhoea in urban slum dwellers in India. J Trop Pediatr 48: 331–334.
-
5.
Abrar UI, Haq K, Gul NA, Hammad HM, Bibi Y, Mohsan J, 2015. Prevalence of Giardia intestinalis and Hymenolepis nana in Afghan refugee population in Mianwali District, Pakistan. Afr Health Sci 15: 394–400.
-
6.
Maco-Flores V, Marcos-Raymundo L, Terashima-Iwashita A, Samalvides-Cuba F, Miranda-Sanchez E, Espinoza-Babilon J, Gotuzzo-Herencia J, 2002. Fas-2 ELISA and the rapid sedimentation technique modified by Lumbreras for Fasciola hepatica infection diagnosis. Rev Med Hered 13: 49–57. Available at: http://www.scielo.org.pe/pdf/rmh/v13n2/v13n2ao3.pdf. Accessed November 22, 2015.
-
7.
Jagota SC, 1986. Albendazole, a broad-spectrum anthelmintic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients. Clin Ther 8: 226–231.
-
8.
Horton J, 2000. Albendazole: a review of anthelminthic efficacy and safety in humans. Parasitology 121 (Suppl): S113–S132.
-
9.
Soares Magalhaes RJ, Fancony C, Gamboa D, Langa AJ, Sousa-Figueiredo JC, Clements ACA, Vaz Nery S, 2013. Extending helminth control beyond STH and schistosomiasis: the case of human hymenolepiasis. PLoS Negl Trop Dis 7: e2321.
-
10.
Machicado JD, Marcos LA, Tello R, Canales M, Terashima A, Gotuzzo E, 2012. Diagnosis of soil-transmitted helminthiasis in an Amazonic community of Peru using multiple diagnostic techniques. Trans Roy Soc Trop Med 106: 333–339.
-
11.
Tefera E, Mohammed J, Mitiku H, 2015. Intestinal helminth infections among elementary students in Babile town, eastern Ethiopia. Pan Afr Med J 20: 50.
-
12.
Romero-Cabello R, Godinez-Hana L, Gutierrez-Quiroz M, 1991. Clinical aspects of hymenolepiasis in pediatrics. Bol Med Hosp Infant Mex 48: 101–105 [Spanish].
-
13.
Suarez-Hernandez M, Bonet-Couce E, Diaz-Gonzalez M, Ocampo-Ruiz I, Vidal-Garcia I, 1998. Epidemiology study on Hymenolepsis nana infection in Ciego de Avila Province, Cuba. Bol Chil Parasitol 53: 31–34 [Spanish].
-
14.
Abdel Hamid M, Eljack I, Osman M, Elaagip A, Muneer M, 2015. The prevalence of Hymenolepis nana among preschool children of displacement communities in Khartoum state, Sudan: a cross-sectional study. Travel Med Infect Dis 13: 172–177.
-
15.
Willcocks B, Mcauliffe G, Baird R, 2015. Dwarf tapeworm (Hymenolepis nana): characteristics in the northern territory 2002–2013. J Paediatr Child Health 51: 982–987.
-
16.
Khalil H, El Shimi S, Sarwat M, Fawzy A, El Shimi A, 1991. Recent study of Hymenolepsis nana infection in Egyptian children. J Egypt Soc Parasitol 21: 293–300.
-
17.
Stephenson LS, Latham MC, Adams EJ, Kinoti SN, Pertet A, 1993. Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice-yearly treatment with albendazole. J Nutr 123: 656–665.
-
18.
Stephenson LS, Kinoti SN, Latham MC, Kurz KM, Kyobe J, 1989. Single dose metrifonate or praziquantel treatment in Kenyan children. I. Effects on Schistosoma haematobium, hookworm, hemoglobin levels, splenomegaly, and hepatomegaly. Am J Trop Med Hyg 41: 436–444.
-
19.
Chero J, Saito M, Bustos J, Blanco E, Gonzalvez G, Garcia HH, Cysticercosis Working Group Peru, 2006. Hymenolepis nana infection: symptoms and response to nitazoxanide in field conditions. Trans R Soc Trop Med Hyg 101: 203–205.
-
20.
Muniz-Junqueira MI, Queiróz EF, 2002. Relationship between protein-energy malnutrition, vitamin A, and parasitoses in children living in Brasília. Rev Soc Bras Med Trop 35: 133–142.
-
21.
Oliveira D, Ferreira FS, Atouguia J, Fortes F, Guerra A, 2015. Infections by intestinal parasites, stunting, and anemia in school-aged children in southern Angola. PLoS One 10: e0137327.
-
22.
Liu C, Luo R, Yi H, Zhang L, Li S, Bai Y, Medina A, Rozelle S, Smith S, Wang G, Wang J, 2015. Soil-transmitted helminths in southwestern China: a cross-sectional study of links to cognitive ability, nutrition, and school performance among children. PLoS Negl Trop Dis 9: e0003877.
-
23.
Echazú A, Bonanno D, Juarez M, Cajal SP, Heredia V, Caropresi S, Cimino RO, Caro N, Vargas PA, Paredes G, Krolewiecki AJ, 2015. Effect of poor access to water and sanitation as risk factors for soil-transmitted helminth infection: selectiveness by the infective route. PLoS Negl Trop Dis 9: e0004111.
-
24.
Strunz EC, Addiss DG, Stocks ME, Ogden S, Utzinger J, Freeman MC, 2014. Water, sanitation, hygiene, and soil-transmitted helminth infection: a systematic review and meta-analysis. PLoS Med 11: e1001620.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 924 | 655 | 24 |
| Full Text Views | 925 | 7 | 0 |
| PDF Downloads | 505 | 8 | 0 |