ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Yang J, Chen J, Yue J, Liu L, Han M, Wang H, 2014. Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in eastern China. Tuberculosis (Edinb) 94: 657–663.
-
2.
Zumla A, George A, Sharma V, Herbert RH, Baroness Masham of Ilton, Oxley A, Oliver M, 2015. The WHO 2014 global tuberculosis report: further to go. Lancet Glob Health 3: e10–e12.
-
3.
Zhang Y, Zhang J, Zeng L, Huang H, Yang M, Fu X, Tian C, Xiang Z, Huang J, Fan H, 2012. The 2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis. PLoS One 7: e38918.
-
4.
Roh EY, Yoon JH, Shin S, Song EY, Park MH, 2015. Association of TAP1 and TAP2 genes with susceptibility to pulmonary tuberculosis in Koreans. APMIS 123: 457–464.
-
5.
Stead WW, Senner JW, Reddick WT, Lofgren JP, 1990. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 322: 422–427.
-
6.
Lu J, Pan H, Chen Y, Tang S, Feng Y, Qiu S, Zhang S, Wu L, Xu R, Peng X, Wang J, Lu C, 2014. Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis. Gene 543: 140–144.
-
7.
Bahari G, Hashemi M, Taheri M, Naderi M, Moazeni-Roodi A, Kouhpayeh HR, Eskandari-Nasab E, 2013. Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, southeast Iran. Genet Mol Res 12: 160–166.
-
8.
Herrmann JL, Zhang Y, Jiang T, Yang X, Xue Y, Wang C, Liu J, Zhang X, Chen Z, Zhao M, Li JC, 2013. Toll-like receptor-1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis. PLoS One 8: e63357.
-
9.
Singla N, Gupta D, Joshi A, Batra N, Singh J, 2012. Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis. Int J Tuberc Lung Dis 16: 224–229.
-
10.
Carracedo A, 2005. Forensic DNA Typing Protocols. Totowa, NJ: Humana Press.
-
11.
Gabriel S, Ziaugra L, Tabbaa D, 2009. SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr Protoc Hum Genet Chapter 2: Unit 2.12.
-
12.
Adamec C, 1964. Example of the use of the nonparametric test. Test X2 for comparison of 2 independent examples [in Czech]. Cesk Zdrav 12: 613–619.
-
13.
Bland JM, Altman DG, 2000. Statistics notes. The odds ratio. BMJ 320: 1468.
-
14.
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D, 2002. The structure of haplotype blocks in the human genome. Science 296: 2225–2229.
-
15.
Saunders BM, Fernando SL, Sluyter R, Britton WJ, Wiley JS, 2003. A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol 171: 5442–5446.
-
16.
Myers AJ, Eilertson B, Fulton SA, Flynn JL, Canaday DH, 2005. The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection. Infect Immun 73: 3192–3195.
-
17.
Li CM, Campbell SJ, Kumararatne DS, Bellamy R, Ruwende C, McAdam KP, Hill AV, Lammas DA, 2002. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis 186: 1458–1462.
-
18.
Fernando SL, Saunders BM, Sluyter R, Skarratt KK, Goldberg H, Marks GB, Wiley JS, Britton WJ, 2007. A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis. Am J Respir Crit Care Med 175: 360–366.
-
19.
Tekin D, Kayaalti Z, Dalgic N, Cakir E, Soylemezoglu T, Isin Kutlubay B, Aydin Kilic B, 2010. Polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. Pediatr Infect Dis J 29: 779–782.
-
20.
Sharma S, Kumar V, Khosla R, Kajal N, Sarin B, Sehajpal P, 2010. Association of P2X7 receptor +1513 (A → C) polymorphism with tuberculosis in a Punjabi population. Int J Tuberc Lung Dis 14: 1159–1163.
-
21.
Palomino-Doza J, Rahman TJ, Avery PJ, Mayosi BM, Farrall M, Watkins H, Edwards CR, Keavney B, 2008. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension 52: 980–985.
-
22.
Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K, 2014. Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain 10: 75.
-
23.
Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F, 2007. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. J Affect Disord 101: 159–168.
-
24.
Franco-Martinez S, Nino-Moreno P, Bernal-Silva S, Baranda L, Rocha-Meza M, Portales-Cervantes L, Layseca-Espinosa E, Gonzalez-Amaro R, Portales-Perez D, 2006. Expression and function of the purinergic receptor P2X7 in patients with pulmonary tuberculosis. Clin Exp Immunol 146: 253–261.
-
25.
Moller M, Hoal EG, 2010. Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis (Edinb) 90: 71–83.
-
26.
Sambasivan V, Murthy KJ, Reddy R, Vijayalakshimi V, Hasan Q, 2010. P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians. Dis Markers 28: 43–48.
-
27.
Gu BJ, Zhang W, Worthington RA, Sluyter R, Dao-Ung P, Petrou S, Barden JA, Wiley JS, 2001. A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem 276: 11135–11142.
-
28.
Kahlenberg JM, Dubyak GR, 2004. Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol 286: C1100–C1108.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 781 | 672 | 14 |
| Full Text Views | 314 | 7 | 0 |
| PDF Downloads | 133 | 9 | 0 |
P2X7R Gene Polymorphisms are Associated with Increased Risk of Pulmonary Tuberculosis in the Tibetan Chinese Population
Xikai Zhu
Xikai Zhu
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Wen Guo
Wen Guo
Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
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Guoxia Ren
Guoxia Ren
Department of Integrated Traditional and Western Medicine, Xi'an Chest and Tuberculosis Hospital, Xi'an, China.
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Xue He
Xue He
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Qunying Hu
Qunying Hu
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Yuan Zhang
Yuan Zhang
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Longli Kang
Longli Kang
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Dongya Yuan
Dongya Yuan
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Tianbo Jin
Tianbo Jin
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
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In this study, we aim to explore the correlation between single nucleotide polymorphisms (SNPs) in the P2X7R gene and pulmonary tuberculosis (PTB) susceptibility in the Tibetan Chinese population in China. We examined 467 patients with active PTB and 504 healthy controls living in Xi'an and the surrounding area. Eight P2X7R SNPs were genotyped, and association analysis was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were tested by unconditional logistic regression analysis to evaluate the effects of the polymorphisms on PTB risk. P2X7R SNP association analyses were performed using SPSS 17.0 statistical packages and Microsoft Excel, SNP statistics software, Haploview software package (version 4.2), and SHEsis software platform. The results show that the “C” allele of rs656612 in the P2X7R gene was associated with an increased PTB risk by the additive model (OR = 1.307, 95% CI = 1.088–1.570, P = 0.004) and dominant model (rs656612, OR = 1.490, 95% CI = 1.153–1.926, P = 0.002). The “A” allele of rs208290 showed an increased PTB risk by the additive model (OR = 1.418, 95% CI = 1.179–1.706, P < 0.001) and dominant model (OR = 1.680, 95% CI = 1.297–2.177, P < 0.001), whereas the “A” allele of rs7958311 showed an increased risk by the additive model (rs7958311, OR = 1.260, 95% CI = 1.055–1.505, P = 0.011) and recessive model (OR = 1.609, 95% CI = 1.200–2.158, P = 0.001). After Bonferroni correction, rs208290 was found to be associated with PTB in the allele, dominant, and genotype models. In conclusion, our study revealed a significant association between three P2X7R gene polymorphisms (rs656612, rs208290, and rs7958311) and PTB in a Tibetan Chinese population.
Author Notes
Authors' addresses: Xikai Zhu, Xue He, Quanying Hu, Yuan Zhang, Longli Kang, and Tianbo Jin, Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China, E-mails: 478283820@qq.com, 7511361@qq.com, huqunying15@163.com, zhangmengyuann@163.com, longli_kang@163.com, and jintianbo@gmail.com. Wen Guo, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China, E-mail: 250475684@qq.com. Guoxia Ren, Department of Integrated Traditional and Western Medicine, Xi'an Chest and Tuberculosis Hospital, Xi'an, China, E-mail: renguoxia16@163.com. Dongya Yuan, Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China, E-mail: dyyuanxzmz@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Yang J, Chen J, Yue J, Liu L, Han M, Wang H, 2014. Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in eastern China. Tuberculosis (Edinb) 94: 657–663.
-
2.
Zumla A, George A, Sharma V, Herbert RH, Baroness Masham of Ilton, Oxley A, Oliver M, 2015. The WHO 2014 global tuberculosis report: further to go. Lancet Glob Health 3: e10–e12.
-
3.
Zhang Y, Zhang J, Zeng L, Huang H, Yang M, Fu X, Tian C, Xiang Z, Huang J, Fan H, 2012. The 2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis. PLoS One 7: e38918.
-
4.
Roh EY, Yoon JH, Shin S, Song EY, Park MH, 2015. Association of TAP1 and TAP2 genes with susceptibility to pulmonary tuberculosis in Koreans. APMIS 123: 457–464.
-
5.
Stead WW, Senner JW, Reddick WT, Lofgren JP, 1990. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 322: 422–427.
-
6.
Lu J, Pan H, Chen Y, Tang S, Feng Y, Qiu S, Zhang S, Wu L, Xu R, Peng X, Wang J, Lu C, 2014. Genetic polymorphisms of IFNG and IFNGR1 in association with the risk of pulmonary tuberculosis. Gene 543: 140–144.
-
7.
Bahari G, Hashemi M, Taheri M, Naderi M, Moazeni-Roodi A, Kouhpayeh HR, Eskandari-Nasab E, 2013. Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, southeast Iran. Genet Mol Res 12: 160–166.
-
8.
Herrmann JL, Zhang Y, Jiang T, Yang X, Xue Y, Wang C, Liu J, Zhang X, Chen Z, Zhao M, Li JC, 2013. Toll-like receptor-1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis. PLoS One 8: e63357.
-
9.
Singla N, Gupta D, Joshi A, Batra N, Singh J, 2012. Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis. Int J Tuberc Lung Dis 16: 224–229.
-
10.
Carracedo A, 2005. Forensic DNA Typing Protocols. Totowa, NJ: Humana Press.
-
11.
Gabriel S, Ziaugra L, Tabbaa D, 2009. SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr Protoc Hum Genet Chapter 2: Unit 2.12.
-
12.
Adamec C, 1964. Example of the use of the nonparametric test. Test X2 for comparison of 2 independent examples [in Czech]. Cesk Zdrav 12: 613–619.
-
13.
Bland JM, Altman DG, 2000. Statistics notes. The odds ratio. BMJ 320: 1468.
-
14.
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D, 2002. The structure of haplotype blocks in the human genome. Science 296: 2225–2229.
-
15.
Saunders BM, Fernando SL, Sluyter R, Britton WJ, Wiley JS, 2003. A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol 171: 5442–5446.
-
16.
Myers AJ, Eilertson B, Fulton SA, Flynn JL, Canaday DH, 2005. The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection. Infect Immun 73: 3192–3195.
-
17.
Li CM, Campbell SJ, Kumararatne DS, Bellamy R, Ruwende C, McAdam KP, Hill AV, Lammas DA, 2002. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis 186: 1458–1462.
-
18.
Fernando SL, Saunders BM, Sluyter R, Skarratt KK, Goldberg H, Marks GB, Wiley JS, Britton WJ, 2007. A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis. Am J Respir Crit Care Med 175: 360–366.
-
19.
Tekin D, Kayaalti Z, Dalgic N, Cakir E, Soylemezoglu T, Isin Kutlubay B, Aydin Kilic B, 2010. Polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. Pediatr Infect Dis J 29: 779–782.
-
20.
Sharma S, Kumar V, Khosla R, Kajal N, Sarin B, Sehajpal P, 2010. Association of P2X7 receptor +1513 (A → C) polymorphism with tuberculosis in a Punjabi population. Int J Tuberc Lung Dis 14: 1159–1163.
-
21.
Palomino-Doza J, Rahman TJ, Avery PJ, Mayosi BM, Farrall M, Watkins H, Edwards CR, Keavney B, 2008. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension 52: 980–985.
-
22.
Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K, 2014. Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain 10: 75.
-
23.
Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F, 2007. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. J Affect Disord 101: 159–168.
-
24.
Franco-Martinez S, Nino-Moreno P, Bernal-Silva S, Baranda L, Rocha-Meza M, Portales-Cervantes L, Layseca-Espinosa E, Gonzalez-Amaro R, Portales-Perez D, 2006. Expression and function of the purinergic receptor P2X7 in patients with pulmonary tuberculosis. Clin Exp Immunol 146: 253–261.
-
25.
Moller M, Hoal EG, 2010. Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis (Edinb) 90: 71–83.
-
26.
Sambasivan V, Murthy KJ, Reddy R, Vijayalakshimi V, Hasan Q, 2010. P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians. Dis Markers 28: 43–48.
-
27.
Gu BJ, Zhang W, Worthington RA, Sluyter R, Dao-Ung P, Petrou S, Barden JA, Wiley JS, 2001. A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem 276: 11135–11142.
-
28.
Kahlenberg JM, Dubyak GR, 2004. Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol 286: C1100–C1108.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 781 | 672 | 14 |
| Full Text Views | 314 | 7 | 0 |
| PDF Downloads | 133 | 9 | 0 |