Author:
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Reference Manager
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-
1.
Perez-Gracia MT, Garcia M, Suay B, Mateos-Lindemann ML, 2015. Current knowledge on hepatitis E. J Clin Transl Hepatol 3: 117–126.
-
2.
Kamar N, Abravanel F, Lhomme S, Rostaing L, Izopet J, 2015. Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment. Clin Res Hepatol Gastroenterol 39: 20–27.
-
3.
Manor Y, Shulman LM, Kaliner E, Hindiyeh M, Ram D, Sofer D, Moran-Gilad J, Lev B, Grotto I, Gamzu R, Mendelson E, 2014. Intensified environmental surveillance supporting the response to wild poliovirus type 1 silent circulation in Israel, 2013. Euro Surveill 19: 20708.
-
4.
Mor O, Bassal R, Michaeli M, Wax M, Ram D, Cohen-Ezra O, Cohen D, Mendelson E, Ben-Ari Z, Shohat T, 2015. Prevalence of hepatitis E virus antibodies, Israel, 2009–2010. Emerg Infect Dis 21: 692–694.
-
5.
Lachish T, Erez O, Daudi N, Shouval D, Schwartz E, 2015. Acute hepatitis E virus in pregnant women in Israel and in other industrialized countries. J Clin Virol 73: 20–24.
-
6.
Clemente-Casares P, Rodriguez-Manzano J, Girones R, 2009. Hepatitis E virus genotype 3 and sporadically also genotype 1 circulate in the population of Catalonia, Spain. J Water Health 7: 664–673.
-
7.
Lapa D, Capobianchi MR, Garbuglia AR, 2015. Epidemiology of hepatitis E virus in European countries. Int J Mol Sci 16: 25711–25743.
-
8.
Romano L, Paladini S, Tagliacarne C, Canuti M, Bianchi S, Zanetti AR, 2011. Hepatitis E in Italy: a long-term prospective study. J Hepatol 54: 34–40.
-
9.
Manor Y, Blomqvist S, Sofer D, Alfandari J, Halmut T, Abramovitz B, Mendelson E, Shulman LM, 2007. Advanced environmental surveillance and molecular analyses indicate separate importations rather than endemic circulation of wild type 1 poliovirus in Gaza district in 2002. Appl Environ Microbiol 73: 5954–5958.
-
10.
Schlauder GG, Desai SM, Zanetti AR, Tassopoulos NC, Mushahwar IK, 1999. Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV. J Med Virol 57: 243–251.
-
11.
Legrand-Abravanel F, Mansuy JM, Dubois M, Kamar N, Peron JM, Rostaing L, Izopet J, 2009. Hepatitis E virus genotype 3 diversity, France. Emerg Infect Dis 15: 110–114.
-
12.
Huang CC, Nguyen D, Fernandez J, Yun KY, Fry KE, Bradley DW, Tam AW, Reyes GR, 1992. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191: 550–558.
-
13.
McWilliam H, Li W, Uludag M, Squizzato S, Park YM, Buso N, Cowley AP, Lopez R, 2013. Analysis tool web services from the EMBL-EBI. Nucleic Acids Res 41: W597–W600.
-
14.
Perriere G, Gouy M, 1996. WWW-query: an on-line retrieval system for biological sequence banks. Biochimie 78: 364–369.
-
15.
Central Bureau of Statistics, Statistical Abstracts of Israel, 2013. Society and Welfare. Available at: http://www.cbs.gov.il/shnaton64/st_eng07.pdf. Accessed December 8, 2015.
-
16.
Lachish T, Tandlich M, Schwartz E, 2013. Acute hepatitis in Israeli travelers. J Travel Med 20: 232–236.
-
17.
Beji-Hamza A, Hassine-Zaafrane M, Khelifi-Gharbi H, Della Libera S, Iaconelli M, Muscillo M, Petricca S, Ciccaglione AR, Bruni R, Taffon S, Aouni M, La Rosa G, 2015. Hepatitis E virus genotypes 1 and 3 in wastewater samples in Tunisia. Arch Virol 160: 183–189.
-
18.
Smith DB, Paddy JO, Simmonds P, 2016. The use of human sewage screening for community surveillance of hepatitis E virus in the UK. J Med Virol 88: 915–918.
-
19.
Kamel AH, Ali MA, El-Nady HG, Deraz A, Aho S, Pothier P, Belliot G, 2011. Presence of enteric hepatitis viruses in the sewage and population of Greater Cairo. Clin Microbiol Infect 17: 1182–1185.
-
20.
Blackard JT, Rouster SD, Nady S, Galal G, Marzuuk N, Rafaat MM, Daef E, El Din SS, Purcell RH, Emerson SU, Sherman KE, Shata MT, 2009. Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. J Clin Virol 46: 140–144.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 18 | 18 | 5 |
| Full Text Views | 392 | 122 | 0 |
| PDF Downloads | 112 | 21 | 0 |
Hepatitis E Virus Genotype 3 in Sewage and Genotype 1 in Acute Hepatitis Cases, Israel
Daniela Ram
Daniela Ram
Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel.
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Yossi Manor
Yossi Manor
Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel.
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Yael Gozlan
Yael Gozlan
Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel.
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Eli Schwartz
Eli Schwartz
Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Ziv Ben-Ari
Ziv Ben-Ari
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Liver Diseases Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
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Liver Diseases Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
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Ella Mendelson
Ella Mendelson
School of Public Health, Tel Aviv University, Tel Aviv, Israel.
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Orna Mor
Orna Mor
Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel.
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Hepatitis E virus (HEV) is an emerging infectious agent in developed countries. HEV genotypes 1 (G1) and 3 (G3) have been identified in environmental and clinical samples in Europe. In Israel, the overall prevalence of anti-HEV IgG antibodies was found to be 10.6%; however, reports of HEV infection are scarce. In this study, the presence of HEV in Israel was investigated using 169 sewage samples from 32 treatment facilities and 49 samples from acute hepatitis patients, all collected between 2013 and 2015. Fourteen sewage samples, from Haifa (11/18 samples), Tel Aviv (2/29 samples), and Beer Sheva (1/17 samples), regions with good sanitary conditions and middle-high socioeconomic populations, were HEV positive. Among the patient samples, 6.1% (3/49) were HEV positive, all returning travelers from India. Genotype analysis revealed G1 HEV in patients and G3 HEV sequences in sewage. Evidence that HEV could be establishing itself in our region may justify more active surveillance to monitor its spread.
Author Notes
Authors' addresses: Daniela Ram, Yossi Manor, Yael Gozlan, and Orna Mor, Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel, E-mails: daniela.Ram@sheba.health.gov.il, yossi.Manor@sheba.health.gov.il, yael.Gozlan@sheba.health.gov.il, and orna.mor@sheba.health.gov.il. Eli Schwartz, Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, E-mail: eli.schwartz@sheba.health.gov.il. Ziv Ben-Ari, Liver Diseases Center, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, E-mail: ziv.ben-ari@sheba.health.gov.il. Ella Mendelson, Central Virology Laboratory, Ministry of Health, Tel-Hashomer, Ramat-Gan, Israel and School of Public Health, Tel Aviv University, Tel Aviv, Israel, E-mail: ella.mendelson@sheba.health.gov.il.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Perez-Gracia MT, Garcia M, Suay B, Mateos-Lindemann ML, 2015. Current knowledge on hepatitis E. J Clin Transl Hepatol 3: 117–126.
-
2.
Kamar N, Abravanel F, Lhomme S, Rostaing L, Izopet J, 2015. Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment. Clin Res Hepatol Gastroenterol 39: 20–27.
-
3.
Manor Y, Shulman LM, Kaliner E, Hindiyeh M, Ram D, Sofer D, Moran-Gilad J, Lev B, Grotto I, Gamzu R, Mendelson E, 2014. Intensified environmental surveillance supporting the response to wild poliovirus type 1 silent circulation in Israel, 2013. Euro Surveill 19: 20708.
-
4.
Mor O, Bassal R, Michaeli M, Wax M, Ram D, Cohen-Ezra O, Cohen D, Mendelson E, Ben-Ari Z, Shohat T, 2015. Prevalence of hepatitis E virus antibodies, Israel, 2009–2010. Emerg Infect Dis 21: 692–694.
-
5.
Lachish T, Erez O, Daudi N, Shouval D, Schwartz E, 2015. Acute hepatitis E virus in pregnant women in Israel and in other industrialized countries. J Clin Virol 73: 20–24.
-
6.
Clemente-Casares P, Rodriguez-Manzano J, Girones R, 2009. Hepatitis E virus genotype 3 and sporadically also genotype 1 circulate in the population of Catalonia, Spain. J Water Health 7: 664–673.
-
7.
Lapa D, Capobianchi MR, Garbuglia AR, 2015. Epidemiology of hepatitis E virus in European countries. Int J Mol Sci 16: 25711–25743.
-
8.
Romano L, Paladini S, Tagliacarne C, Canuti M, Bianchi S, Zanetti AR, 2011. Hepatitis E in Italy: a long-term prospective study. J Hepatol 54: 34–40.
-
9.
Manor Y, Blomqvist S, Sofer D, Alfandari J, Halmut T, Abramovitz B, Mendelson E, Shulman LM, 2007. Advanced environmental surveillance and molecular analyses indicate separate importations rather than endemic circulation of wild type 1 poliovirus in Gaza district in 2002. Appl Environ Microbiol 73: 5954–5958.
-
10.
Schlauder GG, Desai SM, Zanetti AR, Tassopoulos NC, Mushahwar IK, 1999. Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV. J Med Virol 57: 243–251.
-
11.
Legrand-Abravanel F, Mansuy JM, Dubois M, Kamar N, Peron JM, Rostaing L, Izopet J, 2009. Hepatitis E virus genotype 3 diversity, France. Emerg Infect Dis 15: 110–114.
-
12.
Huang CC, Nguyen D, Fernandez J, Yun KY, Fry KE, Bradley DW, Tam AW, Reyes GR, 1992. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191: 550–558.
-
13.
McWilliam H, Li W, Uludag M, Squizzato S, Park YM, Buso N, Cowley AP, Lopez R, 2013. Analysis tool web services from the EMBL-EBI. Nucleic Acids Res 41: W597–W600.
-
14.
Perriere G, Gouy M, 1996. WWW-query: an on-line retrieval system for biological sequence banks. Biochimie 78: 364–369.
-
15.
Central Bureau of Statistics, Statistical Abstracts of Israel, 2013. Society and Welfare. Available at: http://www.cbs.gov.il/shnaton64/st_eng07.pdf. Accessed December 8, 2015.
-
16.
Lachish T, Tandlich M, Schwartz E, 2013. Acute hepatitis in Israeli travelers. J Travel Med 20: 232–236.
-
17.
Beji-Hamza A, Hassine-Zaafrane M, Khelifi-Gharbi H, Della Libera S, Iaconelli M, Muscillo M, Petricca S, Ciccaglione AR, Bruni R, Taffon S, Aouni M, La Rosa G, 2015. Hepatitis E virus genotypes 1 and 3 in wastewater samples in Tunisia. Arch Virol 160: 183–189.
-
18.
Smith DB, Paddy JO, Simmonds P, 2016. The use of human sewage screening for community surveillance of hepatitis E virus in the UK. J Med Virol 88: 915–918.
-
19.
Kamel AH, Ali MA, El-Nady HG, Deraz A, Aho S, Pothier P, Belliot G, 2011. Presence of enteric hepatitis viruses in the sewage and population of Greater Cairo. Clin Microbiol Infect 17: 1182–1185.
-
20.
Blackard JT, Rouster SD, Nady S, Galal G, Marzuuk N, Rafaat MM, Daef E, El Din SS, Purcell RH, Emerson SU, Sherman KE, Shata MT, 2009. Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. J Clin Virol 46: 140–144.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 18 | 18 | 5 |
| Full Text Views | 392 | 122 | 0 |
| PDF Downloads | 112 | 21 | 0 |