• 1.

    Mogasale V, Maskery B, Ochiai RL, Lee JS, Mogasale VV, Ramani E, Kim YE, Park JK, Wierzba TF, 2014. Burden of typhoid fever in low-income and middle-income countries: a systematic, literature-based update with risk-factor adjustment. Lancet Glob Health 2: e570e580.

    • Search Google Scholar
    • Export Citation
  • 2.

    Ochiai RL, Acosta CJ, Danovaro-Holliday MC, Baiqing D, Bhattacharya SK, Agtini MD, Bhutta ZA, Canh do G, Ali M, Shin S, Wain J, Page AL, Albert MJ, Farrar J, Abu-Elyazeed R, Pang T, Galindo CM, von Seidlein L, Clemens JD, Domi Typhoid Study Group, 2008. A study of typhoid fever in five Asian countries: disease burden and implications for controls. Bull World Health Organ 86: 260268.

    • Search Google Scholar
    • Export Citation
  • 3.

    Jensenius M, Han PV, Schlagenhauf P, Schwartz E, Parola P, Castelli F, von Sonnenburg F, Loutan L, Leder K, Freedman DO; GeoSentinel Surveillance Network, 2013. Acute and potentially life-threatening tropical diseases in western travelers—a GeoSentinel multicenter study, 1996–2011. Am J Trop Med Hyg 88: 397404.

    • Search Google Scholar
    • Export Citation
  • 4.

    Effa EE, Lassi ZS, Critchley JA, Garner P, Sinclair D, Olliaro PL, Bhutta ZA, 2011. Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). Cochrane Database Syst Rev 5: CD004530.

    • Search Google Scholar
    • Export Citation
  • 5.

    Patel TA, Armstrong M, Morris-Jones SD, Wright SG, Doherty T, 2010. Imported enteric fever: case series from the hospital for tropical diseases, London, United Kingdom. Am J Trop Med Hyg 82: 11211126.

    • Search Google Scholar
    • Export Citation
  • 6.

    Hassing RJ, Goessens WH, Mevius DJ, van Pelt W, Mouton JW, Verbon A, van Genderen PJ, 2013. Decreased ciprofloxacin susceptibility in Salmonella Typhi and Paratyphi infections in ill-returned travellers: the impact on clinical outcome and future treatment options. Eur J Clin Microbiol Infect Dis 32: 12951301.

    • Search Google Scholar
    • Export Citation
  • 7.

    Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup, 2013. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41: 580637.

    • Search Google Scholar
    • Export Citation
  • 8.

    Cunha BA, 2000. The diagnostic significance of relative bradycardia in infectious disease. Clin Microbiol Infect 6: 633634.

  • 9.

    Hassing RJ, Goessens WH, van Pelt W, Mevius DJ, Stricker BH, Molhoek N, Verbon A, van Genderen PJ, 2014. Salmonella subtypes with increased MICs for azithromycin in travelers returned to The Netherlands. Emerg Infect Dis 20: 705708.

    • Search Google Scholar
    • Export Citation
  • 10.

    Mawatari M, Kato Y, Hayakawa K, Morita M, Yamada K, Mezaki K, Kobayashi T, Fujiya Y, Kutsuna S, Takeshita N, Kanagawa S, Ohnishi M, Izumiya H, Ohmagari N, 2013. Salmonella enterica serotype Paratyphi A carrying CTX-M-15 type extended-spectrum beta-lactamase isolated from a Japanese traveller returning from India, Japan, July 2013. Euro Surveill 18: 20632.

    • Search Google Scholar
    • Export Citation
  • 11.

    Tourdjman M, Le Hello S, Gossner C, Delmas G, Tubiana S, Fabre L, Kerléguer A, Tarantola A, Fruth A, Friesema I, Thorstensen Brandal L, Lawrence J, Fisher I, Dufour M, Weill FX, de Valk H, 2013. Unusual increase in reported cases of paratyphoid A fever among travellers returning from Cambodia, January to September 2013. Euro Surveill 18: 20594.

    • Search Google Scholar
    • Export Citation
  • 12.

    Saitoh T, Morita M, Shimada T, Izumiya H, Kanayama A, Oishi K, Ohnishi M, Sunagawa T, 2015. Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013. Epidemiol Infect 144: 602606.

    • Search Google Scholar
    • Export Citation
  • 13.

    Ackers ML, Puhr ND, Tauxe RV, Mintz ED, 2000. Laboratory-based surveillance of Salmonella serotype Typhi infections in the United States: antimicrobial resistance on the rise. JAMA 283: 26682673.

    • Search Google Scholar
    • Export Citation
  • 14.

    Angell SY, Cetron MS, 2005. Health disparities among travelers visiting friends and relatives abroad. Ann Intern Med 142: 6772.

  • 15.

    Kuvandik C, Karaoglan I, Namiduru M, Baydar I, 2009. Predictive value of clinical and laboratory findings in the diagnosis of the enteric fever. New Microbiol 32: 2530.

    • Search Google Scholar
    • Export Citation
  • 16.

    Lutterloh E, Likaka A, Sejvar J, Manda R, Naiene J, Monroe SS, Khaila T, Chilima B, Mallewa M, Kampondeni SD, Lowther SA, Capewell L, Date K, Townes D, Redwood Y, Schier JG, Nygren B, Tippett Barr B, Demby A, Phiri A, Lungu R, Kaphiyo J, Humphrys M, Talkington D, Joyce K, Stockman LJ, Armstrong GL, Mintz E, 2012. Multidrug-resistant typhoid fever with neurologic findings on the Malawi-Mozambique border. Clin Infect Dis 54: 11001106.

    • Search Google Scholar
    • Export Citation
  • 17.

    Parry CM, Thompson C, Vinh H, Chinh NT, Phuong le T, Ho VA, Hien TT, Wain J, Farrar JJ, Baker S, 2014. Risk factors for the development of severe typhoid fever in Vietnam. BMC Infect Dis 14: 73.

    • Search Google Scholar
    • Export Citation
  • 18.

    Klotz SA, Jorgensen JH, Buckwold FJ, Craven PC, 1984. Typhoid fever. An epidemic with remarkably few clinical signs and symptoms. Arch Intern Med 144: 533537.

    • Search Google Scholar
    • Export Citation
  • 19.

    Connor BA, Schwartz E, 2005. Typhoid and paratyphoid fever in travellers. Lancet Infect Dis 5: 623628.

  • 20.

    Vollaard AM, Ali S, van Asten HA, Widjaja S, Visser LG, Surjadi C, van Dissel JT, 2004. Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. JAMA 291: 26072615.

    • Search Google Scholar
    • Export Citation
  • 21.

    Basnyat B, Maskey AP, Zimmerman MD, Murdoch DR, 2005. Enteric (typhoid) fever in travelers. Clin Infect Dis 41: 14671472.

  • 22.

    Wain J, Hendriksen RS, Mikoleit ML, Keddy KH, Ochiai RL, 2015. Typhoid fever. Lancet 385: 11361145.

  • 23.

    Frenck RW, Nakhla I, Sultan Y, Bassily SB, Girgis YF, David J, Butler TC, Girgis NI, Morsy M, 2000. Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. Clin Infect Dis 31: 11341138.

    • Search Google Scholar
    • Export Citation
  • 24.

    Thaver D, Zaidi AK, Critchley J, Azmatullah A, Madni SA, Bhutta ZA, 2009. A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis. BMJ 338: b1865.

    • Search Google Scholar
    • Export Citation
  • 25.

    Butler T, 2011. Treatment of typhoid fever in the 21st century: promises and shortcomings. Clin Microbiol Infect 17: 959963.

  • 26.

    Chinh NT, Parry CM, Ly NT, Ha HD, Thong MX, Diep TS, Wain J, White NJ, Farrar JJ, 2000. A randomized controlled comparison of azithromycin and ofloxacin for treatment of multidrug-resistant or nalidixic acid-resistant enteric fever. Antimicrob Agents Chemother 44: 18551859.

    • Search Google Scholar
    • Export Citation
  • 27.

    Tatli MM, Aktas G, Kosecik M, Yilmaz A, 2003. Treatment of typhoid fever in children with a flexible-duration of ceftriaxone, compared with 14-day treatment with chloramphenicol. Int J Antimicrob Agents 21: 350353.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 373 121 2
PDF Downloads 136 42 1
 
 
 
 
 
 
 
 
 
 
 

Case Series of Imported Enteric Fever at a Referral Center in Tokyo, Japan: Antibiotic Susceptibility and Risk Factors for Relapse

Takashi MatonoDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Takashi Matono in
Current site
Google Scholar
PubMed
Close
,
Yasuyuki KatoDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Yasuyuki Kato in
Current site
Google Scholar
PubMed
Close
,
Masatomo MoritaDepartment of Bacteriology I, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Masatomo Morita in
Current site
Google Scholar
PubMed
Close
,
Hidemasa IzumiyaDepartment of Bacteriology I, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Hidemasa Izumiya in
Current site
Google Scholar
PubMed
Close
,
Kei YamamotoDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Kei Yamamoto in
Current site
Google Scholar
PubMed
Close
,
Satoshi KutsunaDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Satoshi Kutsuna in
Current site
Google Scholar
PubMed
Close
,
Nozomi TakeshitaDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Nozomi Takeshita in
Current site
Google Scholar
PubMed
Close
,
Kayoko HayakawaDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Kayoko Hayakawa in
Current site
Google Scholar
PubMed
Close
,
Kazuhisa MezakiMicrobiology Laboratory, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Kazuhisa Mezaki in
Current site
Google Scholar
PubMed
Close
,
Maho KawamuraDepartment of Microbiology, Tokyo Metropolitan Institute of Public Health, Hyakunincho, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Maho Kawamura in
Current site
Google Scholar
PubMed
Close
,
Noriko KonishiDepartment of Microbiology, Tokyo Metropolitan Institute of Public Health, Hyakunincho, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Noriko Konishi in
Current site
Google Scholar
PubMed
Close
,
Yasutaka MizunoDepartment of Infectious Diseases, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Yasutaka Mizuno in
Current site
Google Scholar
PubMed
Close
,
Shuzo KanagawaDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Shuzo Kanagawa in
Current site
Google Scholar
PubMed
Close
, and
Norio OhmagariDisease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.

Search for other papers by Norio Ohmagari in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

Owing to the increase in Salmonella strains with decreased fluoroquinolone susceptibility in the endemic areas, we have been treating enteric fever with intravenous ceftriaxone empirically since 2007. In this study, we reevaluated our treatment protocol. This retrospective cohort study was conducted at a single institute in Tokyo, Japan, between January 2006 and December 2013. Enteric fever was defined as isolation of Salmonella Typhi or Salmonella Paratyphi A, B, and C from the blood and/or stool of patients with fever. Of the 35 patients with imported enteric fever, 28 (80%) had returned from south Asia. Ciprofloxacin-susceptible strains were detected in only 12% of the cases. The isolates showed excellent susceptibility to ampicillin (91%), chloramphenicol (94%), ceftriaxone (97%), and azithromycin (97%). One case of Salmonella Paratyphi B was excluded, and of the remaining 34 patients, 56% were treated with ceftriaxone alone, 26% with ceftriaxone then fluoroquinolone, and 9% with levofloxacin alone. The overall relapse rate was 6.1%; however, among those receiving ceftriaxone monotherapy, the relapse rate was 11% (N = 2). The relapse group was characterized by longer times to treatment initiation (P = 0.035) and defervescence (> 7 days) after treatment initiation (P = 0.022). In such cases, we recommend that ceftriaxone treatment be continued for > 4 days after defervescence or be changed to fluoroquinolone if the strains are found to be susceptible to prevent relapse. Furthermore, ampicillin and chloramphenicol, which are no longer prescribed, may be reconsidered as treatment options in Asia.

Author Notes

* Address correspondence to Yasuyuki Kato, Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. E-mail: ykato@hosp.ncgm.go.jp

Financial support: This work is supported by a grant from the Ministry of Health, Labor, and Welfare (H24-shinkou-ippan-013).

Authors' addresses: Takashi Matono and Yasuyuki Kato, Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan, E-mails: sincedec2012@gmail.com and ykato@hosp.ncgm.go.jp. Masatomo Morita and Hidemasa Izumiya, Department of Bacteriology I, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan, E-mails: mmorita@niid.go.jp and izumiya@nih.go.jp. Kei Yamamoto, Satoshi Kutsuna, Nozomi Takeshita, and Kayoko Hayakawa, Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan, E-mails: nicepoko@gmail.com, sonare.since1192@gmail.com, nozomitake@gmail.com, and kayokohayakawa@gmail.com. Kazuhisa Mezaki, Microbiology Laboratory, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan, E-mail: kmezaki@hosp.ncgm.go.jp. Maho Kawamura and Noriko Konishi, Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Hyakunincho, Shinjuku-ku, Tokyo, Japan, E-mails: Maho_Kawamura@member.metro.tokyo.jp and Noriko_Konishi@member.metro.tokyo.jp. Yasutaka Mizuno, Department of Infectious Diseases, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan, E-mail: mizuno@tokyo-med.ac.jp. Shuzo Kanagawa and Norio Ohmagari, Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, E-mails: skanagaw@hosp.ncgm.go.jp and nohmagari@hosp.ncgm.go.jp.

Save