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Real-Time Polymerase Chain Reaction in Stool Detects Transmission of Strongyloides stercoralis from an Infected Donor to Solid Organ Transplant Recipients

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  • ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic–Universitat de Barcelona, Barcelona, Spain; Donation and Transplant Coordination Section, Hospital Clinic–Universitat de Barcelona, Barcelona, Spain; Department of Parasitology, National Centre for Microbiology, Instituto de Salud Carlos III (CNM-ISCIII), Majadahonda, Madrid, Spain; Department of Cardiology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)–Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain; Department of Intensive Care, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)–Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain

Solid organ transplant recipients can acquire Strongyloides stercoralis from an infected donor. The diagnosis of S. stercoralis in immunocompromised individuals may be challenging due to a lower sensitivity of available parasitological and serological methods, compared with immunocompetent individuals. Recently, a real-time polymerase chain reaction (RT-PCR) in stool has been developed for S. stercoralis diagnosis. We report two cases of S. stercoralis infection transmitted by a donor to two solid organ transplant recipients, who were diagnosed with RT-PCR in stool. This test could play an important role in S. stercoralis diagnosis in immunosuppressed patients, facilitating rapid treatment initiation and reducing the risk of severe strongyloidiasis. Adherence to current recommendations of screening among donors and recipients from endemic areas is also urgently needed.

Author Notes

* Address correspondence to Joan Gómez-Junyent, ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic–Universitat de Barcelona, c/Rosselló 132, 4°, 08036 Barcelona, Spain. E-mail: gjunyent@hotmail.com

Financial support: This study was funded by Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI) and by the 6th National Plan (PN) of Research, Development and Innovation (I+D+I) 2008–2011, Carlos III Health Institute (ISCIII) General Division Networks and Cooperative Research Centres + Collaborative Research Network on Tropical Diseases (RICET) (RD12/0018/0010 and RD12/0018/0011).

Authors' addresses: Joan Gómez-Junyent and José Muñoz, ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic–Universitat de Barcelona, Barcelona, Spain, E-mails: gjunyent@hotmail.com and jose.munoz@isglobal.org. David Paredes-Zapata and Ángel Ruiz-Arranz, Donation and Transplant Coordination Section, Hospital Clínic–Universitat de Barcelona, Barcelona, Spain, E-mails: dparedes@clinic.ub.es and aruiz@clinic.ub.es. Esperanza Rodríguez de las Parras and José María Saugar, Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III (CNM-ISCIII), Madrid, Spain, E-mails: erodrgez@isciii.es and jmsaugar@isciii.es. José González-Costello, Department of Cardiology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)–Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain, E-mail: jgcostello@hotmail.com. Rosario Cañizares, Department of Intensive Care, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)–Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain, E-mail: rcanizares@bellvitgehospital.cat.

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