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Polymerase Chain Reaction in the Diagnosis of Visceral Leishmaniasis Recurrence in the Setting of Negative Splenic Smears

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  • International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Mymensingh Medical College Hospital, Mymensingh, Bangladesh
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This report presents two cases of visceral leishmaniasis (VL) recurrence where the microscopy of the splenic smear failed in diagnosis. However, a strong clinical suspicion compelled further evaluation by polymerase chain reaction (PCR), which validated the etiology. This short report highlights the usefulness of PCR in diagnosing cases of suspected smear-negative VL recurrence.

Author Notes

* Address correspondence to Dinesh Mondal, International Center for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68 Sheheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh. E-mail: din63d@icddrb.org

Authors' addresses: Md. Golam Hasnain, Centre for Communicable Disease, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh, E-mail: hasnain.abir@gmail.com. Ariful Basher and Proggananda Nath, Department of Internal Medicine, Mymensingh Medical College Hospital, Mymensingh, Bangladesh, E-mails: ariful.dr@gmail.com and progganath@yahoo.com. Prakash Ghosh, Faria Hossain, Md. Shakhawat Hossain, and Dinesh Mondal, Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh, E-mails: dreamix888@yahoo.com, faria109@gmail.com, realengewu@yahoo.com, and din63d@icddrb.org.

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