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1.
Wu JY, Lun ZR, James AA, Chen XG, 2010. Dengue fever in mainland China. Am J Trop Med Hyg 83: 664–671.
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2.
Jin X, Lee M, Shu J, 2015. Dengue fever in China: an emerging problem demands attention. Emerg Microbes Infect 4: e3.
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3.
Wu F, Liu Q, Lu L, Wang J, Song X, Ren D, 2011. Distribution of Aedes albopictus (Diptera: Culicidae) in northwestern China. Vector Borne Zoonotic Dis 11: 1181–1186.
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4.
Wang G, Zhang H, Cao X, Zhang X, Wang G, He Z, Yu C, Zhao T, 2014. Using GARP to predict the range of Aedes aegypti in China. Southeast Asian J Trop Med Public Health 45: 290–298.
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5.
Sang S, Chen B, Wu H, Yang Z, Di B, Wang L, Tao X, Liu X, Liu Q, 2015. Dengue is still an imported disease in China: a case study in Guangzhou. Infect Genet Evol 32: 178–190.
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Zhao H, Zhao L, Jiang T, Li X, Fan H, Hong W, Zhang Y, Zhu Q, Ye Q, Tong Y, Cao W, Zhang F, Qin C, 2014. Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014. Sci China Life Sci 57: 1149–1155.
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Chen R, Vasilakis N, 2011. Dengue—quo tu et quo vadis? Viruses 3: 1562–1608.
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Allicock OM, Lemey P, Tatem AJ, Pybus OG, Bennett SN, Mueller BA, Suchard MA, Foster JE, Rambaut A, Carrington CV, 2012. Phylogeography and population dynamics of dengue viruses in the Americas. Mol Biol Evol 29: 1533–1543.
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Williams M, Mayer SV, Johnson WL, Chen R, Volkova E, Vilcarromero S, Widen SG, Wood TG, Suarez-Ognio L, Long KC, Hanley KA, Morrison AC, Vasilakis N, Halsey ES, 2014. Lineage II of southeast Asian/American DENV-2 is associated with a severe dengue outbreak in the Peruvian Amazon. Am J Trop Med Hyg 91: 611–620.
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Faye O, Ba Y, Faye O, Talla C, Diallo D, Chen R, Mondo M, Ba R, Macondo E, Siby T, Weaver SC, Diallo M, Sall AA, 2014. Urban epidemic of dengue virus serotype 3 infection, Senegal, 2009. Emerg Infect Dis 20: 456–459.
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Halstead SB, Porterfield JS, O'Rourke EJ, 1980. Enhancement of dengue virus infection in monocytes by flavivirus antisera. Am J Trop Med Hyg 29: 638–642.
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Zhong NS, Zheng BJ, Li YM, Poon LLM, Xie ZH, Chan KH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris JSM, Guan Y, 2003. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet 362: 1353–1358.
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Carrillo-Valenzo E, Danis-Lozano R, Velasco-Hernandez JX, Sanchez-Burgos G, Alpuche C, Lopez I, Rosales C, Baronti C, de Lamballerie X, Holmes EC, Ramos-Castañeda J, 2010. Evolution of dengue virus in Mexico is characterized by frequent lineage replacement. Arch Virol 155: 1401–1412.
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Dengue in China: Comprehensive Phylogenetic Evaluation Reveals Evidence of Endemicity and Complex Genetic Diversity
Rubing Chen
Rubing Chen
Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Jiangsu, China
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Guan-Zhu Han
Guan-Zhu Han
Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Jiangsu, China
Search for other papers by Guan-Zhu Han in
Current site
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PubMed
Search for other papers by Guan-Zhu Han in
Current site
Google Scholar
PubMed
Despite the increasing threat of dengue outbreaks in China, it is still considered as an imported disease and its introduction and/or circulation patterns remain obscure. On the basis of the most extensive phylogenetic analysis to date, we showed highly complex genetic diversity of dengue viruses (DENVs) in south China with up to 20 different clades/lineages from multiple serotypes co-circulating in the same year. Despite that most of these clades/lineages were resulted from imported cases, evidence of local persistence of DENV serotype 1 (DENV-1) was observed, indicating its potential endemicity in Guangdong province. This study, therefore, provided an overview of DENV genetic diversity and evolutionary dynamics in China, which will be useful for developing policies to prevent and control future dengue outbreaks in China.
Author Notes
Financial support: This work is supported by the Institute for Human Infections and Immunity at University of Texas Medical Branch at Galveston. Guan-Zhu Han is supported by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
Authors' addresses: Rubing Chen, Department of Pathology, University of Texas Medical Branch, Galveston, TX, E-mail: ruchen@utmb.edu. Guan-Zhu Han Nanjing Normal University, Nanjing, China, E-mail: guanzhu@njnu.edu.cn.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Wu JY, Lun ZR, James AA, Chen XG, 2010. Dengue fever in mainland China. Am J Trop Med Hyg 83: 664–671.
-
2.
Jin X, Lee M, Shu J, 2015. Dengue fever in China: an emerging problem demands attention. Emerg Microbes Infect 4: e3.
-
3.
Wu F, Liu Q, Lu L, Wang J, Song X, Ren D, 2011. Distribution of Aedes albopictus (Diptera: Culicidae) in northwestern China. Vector Borne Zoonotic Dis 11: 1181–1186.
-
4.
Wang G, Zhang H, Cao X, Zhang X, Wang G, He Z, Yu C, Zhao T, 2014. Using GARP to predict the range of Aedes aegypti in China. Southeast Asian J Trop Med Public Health 45: 290–298.
-
5.
Sang S, Chen B, Wu H, Yang Z, Di B, Wang L, Tao X, Liu X, Liu Q, 2015. Dengue is still an imported disease in China: a case study in Guangzhou. Infect Genet Evol 32: 178–190.
-
6.
Zhao H, Zhao L, Jiang T, Li X, Fan H, Hong W, Zhang Y, Zhu Q, Ye Q, Tong Y, Cao W, Zhang F, Qin C, 2014. Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014. Sci China Life Sci 57: 1149–1155.
-
7.
Chen R, Vasilakis N, 2011. Dengue—quo tu et quo vadis? Viruses 3: 1562–1608.
-
8.
Allicock OM, Lemey P, Tatem AJ, Pybus OG, Bennett SN, Mueller BA, Suchard MA, Foster JE, Rambaut A, Carrington CV, 2012. Phylogeography and population dynamics of dengue viruses in the Americas. Mol Biol Evol 29: 1533–1543.
-
9.
Swofford DL, 1998. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sunderland, MA: Sinauer Associates.
-
10.
Price MN, Dehal PS, Arkin AP, 2010. FastTree 2—approximately maximum-likelihood trees for large alignments. PLoS One 5: e9490.
-
11.
Williams M, Mayer SV, Johnson WL, Chen R, Volkova E, Vilcarromero S, Widen SG, Wood TG, Suarez-Ognio L, Long KC, Hanley KA, Morrison AC, Vasilakis N, Halsey ES, 2014. Lineage II of southeast Asian/American DENV-2 is associated with a severe dengue outbreak in the Peruvian Amazon. Am J Trop Med Hyg 91: 611–620.
-
12.
Faye O, Ba Y, Faye O, Talla C, Diallo D, Chen R, Mondo M, Ba R, Macondo E, Siby T, Weaver SC, Diallo M, Sall AA, 2014. Urban epidemic of dengue virus serotype 3 infection, Senegal, 2009. Emerg Infect Dis 20: 456–459.
-
13.
Halstead SB, Porterfield JS, O'Rourke EJ, 1980. Enhancement of dengue virus infection in monocytes by flavivirus antisera. Am J Trop Med Hyg 29: 638–642.
-
14.
Halstead SB, 1979. In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. J Infect Dis 140: 527–533.
-
15.
Zhong NS, Zheng BJ, Li YM, Poon LLM, Xie ZH, Chan KH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris JSM, Guan Y, 2003. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet 362: 1353–1358.
-
16.
Carrillo-Valenzo E, Danis-Lozano R, Velasco-Hernandez JX, Sanchez-Burgos G, Alpuche C, Lopez I, Rosales C, Baronti C, de Lamballerie X, Holmes EC, Ramos-Castañeda J, 2010. Evolution of dengue virus in Mexico is characterized by frequent lineage replacement. Arch Virol 155: 1401–1412.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1044 | 968 | 19 |
| Full Text Views | 300 | 11 | 2 |
| PDF Downloads | 96 | 16 | 2 |