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Predictive Value of School-Aged Children's Schistosomiasis Prevalence and Egg Intensity for Other Age Groups in Western Kenya

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  • Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia
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World Health Organization recommendations for the timing and target population for mass drug administration (MDA) for schistosomiasis are based on the prevalence of infection in school children within a given community. In a large study comparing MDA approaches for Schistosoma mansoni control, we evaluated whether prevalence of infection and egg burdens in 9- to 12-year-old students reflected infection levels in young children and adults in the same community. Cross-sectional surveys of preadolescents (9–12 years old) were compared with those of first year students (5–8 years old) in 225 villages and adults (20–55 years old) in 150 villages along the Kenyan shores of Lake Victoria. Village schistosomiasis prevalence and intensity levels in preadolescents strongly correlated (P < 0.0001) with prevalence and infection intensity for other age groups in the community. Our findings suggest that S. mansoni prevalence and intensity among 9- to 12-year-olds are valid for community sampling purposes in mapping for MDAs.

Author Notes

* Address correspondence to W. Evan Secor, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-D65, Atlanta, GA 30329. E-mail: was4@cdc.gov

Financial support: This study was made possible by the generous support from the University of Georgia Research Foundation, Inc., which is funded by the Bill and Melinda Gates Foundation for this SCORE project.

Authors' addresses: Pauline N. M. Mwinzi, Geoffrey Muchiri, Martin Omedo, Bernard Abudho, and Diana M. S. Karanja, Neglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), E-mails: pmwinzi@kemricdc.org, martowino007@yahoo.com, geoffmosh@yahoo.com, babudho@kemricdc.org, and dkaranja@kemricdc.org. Ryan E. Wiegand, Susan P. Montgomery, and W. Evan Secor, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: fwk2@cdc.gov, zqu6@cdc.gov, and was4@cdc.gov.

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