• 1.

    Carvalho LP, Passos S, Bacellar O, Lessa M, Almeida RP, Magalhaes A, Dutra WO, Gollob KJ, Machado P, de Jesus AR, 2007. Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis. Parasite Immunol 29: 251258.

    • Search Google Scholar
    • Export Citation
  • 2.

    Passos S, Carvalho LP, Costa RS, Campos TM, Novais FO, Magalhaes A, Machado PR, Beiting D, Mosser D, Carvalho EM, Scott P, 2015. Intermediate monocytes contribute to pathologic immune response in Leishmania braziliensis infections. J Infect Dis 211: 274282.

    • Search Google Scholar
    • Export Citation
  • 3.

    Cardoso TM, Machado A, Costa DL, Carvalho LP, Queiroz A, Machado P, Scott P, Carvalho EM, Bacellar O, 2015. Protective and pathological functions of CD8+ T cells in Leishmania braziliensis infection. Infect Immun 83: 898906.

    • Search Google Scholar
    • Export Citation
  • 4.

    Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P, 2013. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathog 9: e1003504.

    • Search Google Scholar
    • Export Citation
  • 5.

    Santos C da S, Boaventura V, Ribeiro Cardoso C, Tavares N, Lordelo MJ, Noronha A, Costa J, Borges VM, de Oliveira CI, Van Weyenbergh J, Barral A, Barral-Netto M, Brodskyn CI, 2013. CD8+ granzyme B+–mediated tissue injury vs. CD4+ IFNγ+–mediated parasite killing in human cutaneous leishmaniasis. J Invest Dermatol 133: 15331540.

    • Search Google Scholar
    • Export Citation
  • 6.

    Faria DR, Souza PE, Duraes FV, Carvalho EM, Gollob KJ, Machado PR, Dutra WO, 2009. Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol 31: 432439.

    • Search Google Scholar
    • Export Citation
  • 7.

    Ezra N, Ochoa MT, Craft N, 2010. Human immunodeficiency virus and leishmaniasis. J Glob Infect Dis 2: 248257.

  • 8.

    Ngouateu OB, Kollo P, Ravel C, Dereure J, Kamtchouing P, Same-Ekobo A, von Stebut E, Maurer M, Dondji B, 2012. Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major/HIV co-infection in Cameroon: results of a large cross-sectional study. Trans R Soc Trop Med Hyg 106: 137142.

    • Search Google Scholar
    • Export Citation
  • 9.

    Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, Lopez-Velez R, Moreno J, 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334359; table of contents.

    • Search Google Scholar
    • Export Citation
  • 10.

    Bacellar O, Lessa H, Schriefer A, Machado P, Ribeiro de Jesus A, Dutra WO, Gollob KJ, Carvalho EM, 2002. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 70: 67346740.

    • Search Google Scholar
    • Export Citation
  • 11.

    Erikstrup C, Kallestrup P, Zinyama R, Gomo E, Mudenge B, Gerstoft J, Ullum H, 2007. Predictors of mortality in a cohort of HIV-1-infected adults in rural Africa. J Acquir Immune Defic Syndr 44: 478483.

    • Search Google Scholar
    • Export Citation
  • 12.

    Zawada AM, Rogacev KS, Rotter B, Winter P, Marell RR, Fliser D, Heine GH, 2011. SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 118: e50e61.

    • Search Google Scholar
    • Export Citation
  • 13.

    Maretti-Mira AC, de Pinho Rodrigues KM, de Oliveira-Neto MP, Pirmez C, Craft N, 2011. MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis. Acta Trop 119: 160164.

    • Search Google Scholar
    • Export Citation
  • 14.

    Campos TM, Passos ST, Novais FO, Beiting DP, Costa RS, Queiroz A, Mosser D, Scott P, Carvalho EM, Carvalho LP, 2014. Matrix metalloproteinase 9 production by monocytes is enhanced by TNF and participates in the pathology of human cutaneous leishmaniasis. PLoS Negl Trop Dis 8: e3282.

    • Search Google Scholar
    • Export Citation
  • 15.

    Weirather JL, Jeronimo SM, Gautam S, Sundar S, Kang M, Kurtz MA, Haque R, Schriefer A, Talhari S, Carvalho EM, Donelson JE, Wilson ME, 2011. Serial quantitative PCR assay for detection, species discrimination, and quantification of Leishmania spp. in human samples. J Clin Microbiol 49: 38923904.

    • Search Google Scholar
    • Export Citation
  • 16.

    Barbosa T, Arruda S, Fernandes BD, Carvalho LP, Cardoso S, Cunha S, Barreto ML, Pereira SM, Rodrigues LC, Barral-Netto M, 2003. BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-gamma response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. Vaccine 21: 21522160.

    • Search Google Scholar
    • Export Citation
  • 17.

    Guimaraes LH, Machado PR, Lago EL, Morgan DJ, Schriefer A, Bacellar O, Carvalho EM, 2009. Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg 103: 712715.

    • Search Google Scholar
    • Export Citation
  • 18.

    Rodrigues MZ, Grassi MF, Mehta S, Zhang XQ, Gois LL, Schooley RT, Badaro R, 2011. Th1/Th2 cytokine profile in patients coinfected with HIV and Leishmania in Brazil. Clin Vaccine Immunol 18: 17651769.

    • Search Google Scholar
    • Export Citation
  • 19.

    Antonelli LR, Dutra WO, Almeida RP, Bacellar O, Carvalho EM, Gollob KJ, 2005. Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis. Immunol Lett 101: 226230.

    • Search Google Scholar
    • Export Citation
  • 20.

    Brito G, Dourado M, Polari L, Celestino D, Carvalho LP, Queiroz A, Carvalho EM, Machado PR, Passos S, 2014. Clinical and immunological outcome in cutaneous leishmaniasis patients treated with pentoxifylline. Am J Trop Med Hyg 90: 617620.

    • Search Google Scholar
    • Export Citation
  • 21.

    Unger A, O'Neal S, Machado PR, Guimaraes LH, Morgan DJ, Schriefer A, Bacellar O, Glesby MJ, Carvalho EM, 2009. Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in northeastern Brazil. Am J Trop Med Hyg 80: 574579.

    • Search Google Scholar
    • Export Citation
  • 22.

    Giudice A, Vendrame C, Bezerra C, Carvalho LP, Delavechia T, Carvalho EM, Bacellar O, 2012. Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection. BMC Infect Dis 12: 75.

    • Search Google Scholar
    • Export Citation
  • 23.

    Cordiali-Fei P, Trento E, D'Agosto G, Bordignon V, Mussi A, Ardigo M, Mastroianni A, Vento A, Solivetti F, Berardesca E, Ensoli F, 2006. Decreased levels of metalloproteinase-9 and angiogenic factors in skin lesions of patients with psoriatic arthritis after therapy with anti-TNF-alpha. J Autoimmune Dis 3: 5.

    • Search Google Scholar
    • Export Citation
  • 24.

    Devillers AC, van Toorenenbergen AW, Klein Heerenbrink GJ, Muldert PG, Oranje AP, 2007. Elevated levels of plasma matrix metalloproteinase-9 in patients with atopic dermatitis: a pilot study. Clin Exp Dermatol 32: 311313.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 156 77 4
PDF Downloads 37 18 1
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus–Leishmania braziliensis Coinfection

View More View Less
  • Serviço de Imunologia, Universidade Federal da Bahia, Salvador, Brazil; Instituto Nacional de Ciências e Tecnologia-Doenças Tropicais (INCT-DT), Salvador, Brazil; Laboratório Avançado de Saúde Pública, Centro de Pesquisa Gonçalo Moniz, Salvador, Brazil; Laboratório de Doenças Tropicais, Universidade Federal da Bahia, Salvador, Brazil; Laboratório de Pesquisa em Infectologia, Universidade Federal da Bahia, Salvador, Brazil
Restricted access

Skin ulcer development in cutaneous leishmaniasis due to Leishmania braziliensis infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF). Herein, we show that despite the absence of Leishmania-driven TNF, a cutaneous leishmaniasis patient with acquired immunodeficiency syndrome developed a skin ulcer. The presence of mononuclear phagocytes and high levels of TNF, chemokine (C-C motif) ligand 2 (CCL2), and metalloproteinase-9 in tissue are identified as potential contributors to immunopathology observed in L. braziliensis-infected patients.

Author Notes

* Address correspondence to Lucas P. Carvalho, Serviço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos (C-HUPES), S/N, Canela, 40.110-160 Salvador, Bahia, Brazil. E-mail: carvalholp@ig.com.br

Financial support: This work was supported by National Institute of Health (AI088650) and the Brazilian Council for research (CNPq).

Authors' addresses: Luiz H. Guimarães, Taís Menezes, Rúbia Costa, Sara Passos, and Lucas P. Carvalho, Serviço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil, E-mails: luizhenriquesg@ig.com.br, menezes.tais@gmail.com, rsuelycosta@gmail.com, saratpassos@hotmail.com, and carvalholp@ig.com.br. Lucas P. Carvalho, Maíra Saldanha, and Sérgio Arruda, Laboratório Avançado de Saúde Pública, Centro de Pesquisa Gonçalo Moniz, Salvador, Brazil, E-mails: mairagsaldanha@gmail.com and arrudasm@gmail.com. Lis Moreno and Roberto Badaró, Laboratório de Doenças Tropicais, Universidade Federal da Bahia, Salvador, Brazil, E-mails: badaro@ufba.br and lis.moreno@gmail.com. Alex Torres, Laboratório de Pesquisa em Infectologia, Universidade Federal da Bahia, Salvador, Brazil, E-mail: ajltorres@gmail.com.

Save