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Efficacy and Safety of Liposomal Amphotericin B for the Treatment of Mucosal Leishmaniasis from the New World: A Retrospective Study

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  • Instituto de Infectologia Emílio Ribas, São Paulo, Brazil; Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil
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The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.

Author Notes

* Address correspondence to José Angelo L. Lindoso, Instituto de Medicina Tropical da Universidade de São Paulo, Avenida Doutor Enéas de Carvalho Aguiar, 470 CEP 05403-000, São Paulo, Brazil. E-mail: jlindoso@usp.br

Financial support: Sao Paulo Research Fecundativo (FAPESP) and Centro de Estudos Emilio Ribas.

Authors' addresses: Mirella A. Cunha, Aline C. Q. Leão, and Rita de Cassia Soler, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, E-mails: mirellaac@gmail.com, aleao@usp.br, and rdcassia@uol.com.br. José Angelo L. Lindoso, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, and Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil, E-mail: jlindoso@usp.br.

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