Blood-Borne Candidatus Borrelia algerica in a Patient with Prolonged Fever in Oran, Algeria

Aurélien Fotso Fotso Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR 6236, CNRS 7278, IRD 198, INSERM 1095, IFR 48, Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France; Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria

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Emmanouil Angelakis Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR 6236, CNRS 7278, IRD 198, INSERM 1095, IFR 48, Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France; Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria

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Nadjet Mouffok Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR 6236, CNRS 7278, IRD 198, INSERM 1095, IFR 48, Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France; Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria

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Michel Drancourt Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR 6236, CNRS 7278, IRD 198, INSERM 1095, IFR 48, Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France; Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria

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Didier Raoult Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR 6236, CNRS 7278, IRD 198, INSERM 1095, IFR 48, Méditerranée Infection, Faculté de Médecine, Aix-Marseille Université, Marseille, France; Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria

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To improve the knowledge base of Borrelia in north Africa, we tested 257 blood samples collected from febrile patients in Oran, Algeria, between January and December 2012 for Borrelia species using flagellin gene polymerase chain reaction sequencing. A sequence indicative of a new Borrelia sp. named Candidatus Borrelia algerica was detected in one blood sample. Further multispacer sequence typing indicated this Borrelia sp. had 97% similarity with Borrelia crocidurae, Borrelia duttonii, and Borrelia recurrentis. In silico comparison of Candidatus B. algerica spacer sequences with those of Borrelia hispanica and Borrelia garinii revealed 94% and 89% similarity, respectively. Candidatus B. algerica is a new relapsing fever Borrelia sp. detected in Oran. Further studies may help predict its epidemiological importance.

Author Notes

* Address correspondence to Emmanouil Angelakis, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille, France. E-mail: angelotasmanos@msn.com

Authors' addresses: Aurélien Fotso Fotso and Emmanouil Angelakis, URMITE, Faculté de Médecine, Marseille, France, E-mails: aurelien74000618@yahoo.fr and angelotasmanos@msn.com. Nadjet Mouffok, Service des Maladies Infectieuses, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria, E-mail: nadjmouf_31@yahoo.fr. Michel Drancourt, Méditerranée Infection, Aix Marseille Université, Marseille, France, and Unité de Recherche sur les Maladies Infectieuses et Tropicale Emergentes, Marseille, France, E-mail: michel.drancourt@univ-amu.fr. Didier Raoult, URMITE UMR 6236, IRD 198, Aix Marseille Université, Marseille, France, E-mail: didier.raoult@gmail.com.

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