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-
1.
Jones-Lopez EC, Ayakaka I, Levin J, Reilly N, Mumbowa F, Dryden-Peterson S, Nyakoojo G, Fennelly K, Temple B, Nakubulwa S, Joloba ML, Okwera A, Eisenach KD, McNerney R, Elliott AM, Ellner JJ, Smith PG, Mugerwa RD, 2011. Effectiveness of the standard WHO recommended retreatment regimen (category II) for tuberculosis in Kampala, Uganda: a prospective cohort study. PLoS Med 8: e1000427.
-
2.
Caminero JA, 2005. Management of multidrug-resistant tuberculosis and patients in retreatment. Eur Respir J 25: 928–936 [Review].
-
3.
WHO, 2004. Treatment of Tuberculosis Guidelines for National Programmes. 3rd edition. WHO/CDC/TB/2003.313. Geneva, Switzerland: World Health Organization.
-
4.
Ponce M, Ugarte-Gil C, Zamudio C, Krapp F, Gotuzzo E, Seas C, 2012. Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru. Trans R Soc Trop Med Hyg 106: 508–510.
-
5.
Temple B, Ayakaka I, Ogwang S, Nabanjja H, Kayes S, Nakubulwa S, Worodria W, Levin J, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Smith PG, Mugerwa RD, Ellner JJ, Jones-Lopez EC, 2008. Rate and amplification of drug resistance among previously-treated patients with tuberculosis in Kampala, Uganda. Clin Infect Dis 47: 1126–1134.
-
6.
Kang'ombe CT, Harries AD, Ito K, Clark T, Nyirenda TE, Aldis W, Nunn PP, Semba RD, Salaniponi FM, 2004. Long-term outcome in patients registered with tuberculosis in Zomba, Malawi: mortality at 7 years according to initial HIV status and type of TB. Int J Tuberc Lung Dis 8: 829–836.
-
7.
Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, Lule JK, Nuwaha F, Joloba ML, 2011. Rates of anti-tuberculosis drug resistance in Kampala–Uganda are low and not associated with HIV infection. PLoS One 6: e16130.
-
8.
Tiemersma EW, van der Werf MJ, Borgdorff MW, Williams BG, Nagelkerke NJ, 2011. Natural history of tuberculosis: duration and fatality of untreated pulmonary tuberculosis in HIV negative patients: a systematic review. PLoS One 6: e17601.
-
9.
Saravia JC, Appleton SC, Rich ML, Sarria TM, Bayona J, Becerra MC, 2005. Retreatment management strategies when first-line tuberculosis therapy fails. Int J Tuberc Lung Dis 9: 421–429.
-
10.
Furin J, Gegia M, Mitnick C, Rich M, Shin S, Becerra M, Drobac P, Farmer P, Hurtado R, Joseph JK, Keshavjee S, Kalandadze I, 2012. Eliminating the category II retreatment regimen from national tuberculosis programme guidelines: the Georgian experience. Bull World Health Organ 90: 63–66.
-
11.
Getahun H, Harrington M, O'Brien R, Nunn P, 2007. Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet 369: 2042–2049.
-
12.
Sterling T, Jenkins C, Jayathilake K, Shepherd B, McGowan C, Gotuzzo E, Veloso V, Cortes C, Padgett D, Crabtree-Ramirez B, 2015. Culture-negative TB is associated with increased mortality in HIV-infected persons. Presented at the annual meeting of the Conference for retroviruses and opportunistic infections (CROI) abstract 833. February 2015, Seattle, WA.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 62 | 62 | 6 |
| Full Text Views | 691 | 84 | 0 |
| PDF Downloads | 89 | 33 | 0 |
High Mortality Associated with Retreatment of Tuberculosis in a Clinic in Kampala, Uganda: A Retrospective Study
Carlos Acuña-Villaorduña
Carlos Acuña-Villaorduña
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Irene Ayakaka
Irene Ayakaka
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Scott Dryden-Peterson
Scott Dryden-Peterson
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Susan Nakubulwa
Susan Nakubulwa
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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William Worodria
William Worodria
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Nancy Reilly
Nancy Reilly
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Jennifer Hosford
Jennifer Hosford
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Kevin P. Fennelly
Kevin P. Fennelly
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Alphonse Okwera
Alphonse Okwera
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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Edward C. Jones-López
Edward C. Jones-López
Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts; Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Medical Research Council–Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda; Section of Infectious Diseases, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, New Jersey; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida; Mulago Hospital Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda
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The World Health Organization recommends for tuberculosis retreatment a regimen of isoniazid (H), rifampicin (R), ethambutol (E), pyrazinamide (Z), and streptomycin (S) for 2 months, followed by H, R, E, and Z for 1 month and H, R, and E for 5 months. Using data from the National Tuberculosis and Leprosy Program registry, this study determined the long-term outcome under programmatic conditions of patients who were prescribed the retreatment regimen in Kampala, Uganda, between 1997 and 2003. Patients were traced to determine their vital status; 62% (234/377) patients were found dead. Having ≤ 2 treatment courses and not completing retreatment were associated with mortality in adjusted analyses.
Author Notes
Financial support: The study was supported by a University of Medicine and Dentistry of New Jersey (now Rutgers University) Foundation award with matching funds from the Division of Infectious Diseases at New Jersey Medical School–Rutgers University.
Authors' addresses: Carlos Acuña-Villaorduña and Edward C. Jones-López, Section of Infectious Diseases, Boston Medical Center, Boston, MA, E-mails: carlosvillaorduna@hotmail.com and edward.jones@bmc.org. Irene Ayakaka, Makerere University–Boston Medical Center Research Collaboration, Kampala, Uganda, E-mail: ayakaka@gmail.com. Scott Dryden-Peterson, Medicine and Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, E-mail: slpeterson@partners.org. Susan Nakubulwa, Uganda Research Unit on AIDS, Medical Research Council–Uganda Virus Research Institute, Entebbe, Uganda, E-mail: susan.nakubulwa@mrcuganda.org. William Worodria, Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda, E-mail: wworo@hotmail.com. Nancy Reilly, Department of Medicine, New Jersey Medical School–Rutgers University, Newark, NJ, E-mail: reillyna@njms.rudgers.edu. Jennifer Hosford and Kevin P. Fennelly, Division of Infectious Diseases and Global Medicine, University of Florida, Gainsville, FL, E-mails: jennifer.hosford@medicine.ufl.edu and kevin.fennelly@medicine.ufl.edu. Alphonse Okwera, Tuberculosis Clinic, Mulago Hospital, Kampala, Uganda, E-mail: a_okwera@mcuwru.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Jones-Lopez EC, Ayakaka I, Levin J, Reilly N, Mumbowa F, Dryden-Peterson S, Nyakoojo G, Fennelly K, Temple B, Nakubulwa S, Joloba ML, Okwera A, Eisenach KD, McNerney R, Elliott AM, Ellner JJ, Smith PG, Mugerwa RD, 2011. Effectiveness of the standard WHO recommended retreatment regimen (category II) for tuberculosis in Kampala, Uganda: a prospective cohort study. PLoS Med 8: e1000427.
-
2.
Caminero JA, 2005. Management of multidrug-resistant tuberculosis and patients in retreatment. Eur Respir J 25: 928–936 [Review].
-
3.
WHO, 2004. Treatment of Tuberculosis Guidelines for National Programmes. 3rd edition. WHO/CDC/TB/2003.313. Geneva, Switzerland: World Health Organization.
-
4.
Ponce M, Ugarte-Gil C, Zamudio C, Krapp F, Gotuzzo E, Seas C, 2012. Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru. Trans R Soc Trop Med Hyg 106: 508–510.
-
5.
Temple B, Ayakaka I, Ogwang S, Nabanjja H, Kayes S, Nakubulwa S, Worodria W, Levin J, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Smith PG, Mugerwa RD, Ellner JJ, Jones-Lopez EC, 2008. Rate and amplification of drug resistance among previously-treated patients with tuberculosis in Kampala, Uganda. Clin Infect Dis 47: 1126–1134.
-
6.
Kang'ombe CT, Harries AD, Ito K, Clark T, Nyirenda TE, Aldis W, Nunn PP, Semba RD, Salaniponi FM, 2004. Long-term outcome in patients registered with tuberculosis in Zomba, Malawi: mortality at 7 years according to initial HIV status and type of TB. Int J Tuberc Lung Dis 8: 829–836.
-
7.
Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, Lule JK, Nuwaha F, Joloba ML, 2011. Rates of anti-tuberculosis drug resistance in Kampala–Uganda are low and not associated with HIV infection. PLoS One 6: e16130.
-
8.
Tiemersma EW, van der Werf MJ, Borgdorff MW, Williams BG, Nagelkerke NJ, 2011. Natural history of tuberculosis: duration and fatality of untreated pulmonary tuberculosis in HIV negative patients: a systematic review. PLoS One 6: e17601.
-
9.
Saravia JC, Appleton SC, Rich ML, Sarria TM, Bayona J, Becerra MC, 2005. Retreatment management strategies when first-line tuberculosis therapy fails. Int J Tuberc Lung Dis 9: 421–429.
-
10.
Furin J, Gegia M, Mitnick C, Rich M, Shin S, Becerra M, Drobac P, Farmer P, Hurtado R, Joseph JK, Keshavjee S, Kalandadze I, 2012. Eliminating the category II retreatment regimen from national tuberculosis programme guidelines: the Georgian experience. Bull World Health Organ 90: 63–66.
-
11.
Getahun H, Harrington M, O'Brien R, Nunn P, 2007. Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet 369: 2042–2049.
-
12.
Sterling T, Jenkins C, Jayathilake K, Shepherd B, McGowan C, Gotuzzo E, Veloso V, Cortes C, Padgett D, Crabtree-Ramirez B, 2015. Culture-negative TB is associated with increased mortality in HIV-infected persons. Presented at the annual meeting of the Conference for retroviruses and opportunistic infections (CROI) abstract 833. February 2015, Seattle, WA.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 62 | 62 | 6 |
| Full Text Views | 691 | 84 | 0 |
| PDF Downloads | 89 | 33 | 0 |