World Health Organization, 2009. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. Available at: http://apps.who.int/iris/bitstream/10665/44188/1/9789241547871_eng.pdf. Accessed January 14, 2014.)| false
BrownHR, ClarkWF, JonesN, WaltherJ, WarrenSL, 1943. The relationship of dehydration and overhydration of the blood plasma to collapse in the management of artificial fever therapy. J Clin Invest22: 471–485.
BrownHRClarkWFJonesNWaltherJWarrenSL, 1943. The relationship of dehydration and overhydration of the blood plasma to collapse in the management of artificial fever therapy. J Clin Invest22: 471–485.)| false
World Health Organization, 2005. The Treatment of Diarrhoea: A Manual for Physicians and Other Senior Health Workers. Available at: http://whqlibdoc.who.int/publications/2005/9241593180.pdf. Accessed January 12, 2014.)| false
MaitlandK, GeorgeE, EvansJ, KiguliS, Olupot-OlupotP, AkechS, OpokaR, EngoruC, NyekoR, MtoveG, ReyburnH, BrentB, NteziyaremyeJ, MpoyaA, PrevattN, DambisyaC, SemakulaD, DdunguA, OkuunyV, WokuliraR, TimbwaM, OtiiB, LevinM, CrawleyJ, BabikerA, GibbD, 2013. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med11: 68.
MaitlandKGeorgeEEvansJKiguliSOlupot-OlupotPAkechSOpokaREngoruCNyekoRMtoveGReyburnHBrentBNteziyaremyeJMpoyaAPrevattNDambisyaCSemakulaDDdunguAOkuunyVWokuliraRTimbwaMOtiiBLevinMCrawleyJBabikerAGibbD, 2013. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med11: 68.)| false
Department of Bioengineering, Rice University, Houston, Texas; Rice 360°, Institute for Global Health Technologies, Rice University, Houston, Texas; 3rd Stone Design, San Rafael, California; Department of Paediatrics, Queen Elizabeth Central Hospital, Blantyre, Malawi
We designed and evaluated the accuracy and usability of a device to regulate the volume of fluid dispensed during intravenous drip therapy. The mechanical system was developed in response to a pressing need articulated by clinicians in pediatric wards throughout sub-Saharan Africa, who require a tool to prevent overhydration in children receiving intravenous fluid in settings that lack burettes or electronic infusion pumps. The device is compatible with most intravenous bags and limits the volume dispensed to a preset amount that can be adjusted in 50 mL increments. Laboratory accuracy over a range of clinically-relevant flow rates, initial bag volumes, and target volumes was within 12.0 mL of the target volume. The ease of use is “excellent,” with a mean system usability score of 84.4 out of 100. Use of the device limits the volume of fluid dispensed during intravenous therapy and could potentially reduce the morbidity and mortality associated with overhydration in children receiving intravenous therapy.
* Address correspondence to Rebecca Richards-Kortum, Rice University, Bioengineering, MS-142, PO Box 1892, Houston, TX 77251-1892. E-mail: email@example.com
Financial support: This program was supported in part by a grant to Rice University from the Howard Hughes Medical Institute through the Precollege and Undergraduate Science Education Program. Additional funding for this project was received from the National Collegiate Inventors and Innovators Alliance, Rice Center for Engineering Leadership, and the Oshman Engineering Design Kitchen.