A Prospective Study of Melioidosis After Environmental Exposure of Healthy Participants to Burkholderia pseudomallei During a Muddy Endurance Challenge

Rebecca Grivas Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Sarah Barklay Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Amber Ruane Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Mark Mayo Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Vanessa Theobald Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Kevin Freeman Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Robert Norton Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Robert W. Baird Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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Bart J. Currie Infectious Diseases and Pathology Departments, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Microbiology Department, The Townsville Hospital, Townsville, Queensland, Australia

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In a prospective study of 123 healthy adults competing in a mud-exposing endurance challenge in the melioidosis-endemic tropical north of the Northern Territory of Australia, there were no asymptomatic seroconversions to Burkholderia pseudomallei using indirect hemagglutination assay. However, one competitor developed melioidosis attributable to infection acquired during the event.

Author Notes

* Address correspondence to Bart J. Currie, Menzies School of Health Research, PO Box 41096, Darwin, Northern Territory 0811, Australia. E-mail: bart.currie@menzies.edu.au

Financial support: This study was supported by a grant from the Australian National Health and Medical Research Council to the Menzies School of Health Research Melioidosis Program.

Authors' addresses: Rebecca Grivas, Sarah Barklay, Amber Ruane, Kevin Freeman, and Robert W. Baird, Royal Darwin Hospital, Darwin, NT, Australia, E-mails: rebecca.grivas@gmail.com, sarah.barklay@nt.gov.au, amber.ruane@nt.gov.au, kevin.freeman@nt.gov.au, and rob.baird@nt.gov.au. Mark Mayo and Vanessa Theobald, Menzies School of Health Research, Darwin, NT, Australia, E-mails: mark.mayo@menzies.edu.au and vanessa.theobald@menzies.edu.au. Robert Norton, The Townsville Hospital, Townsville, QLD, Australia, E-mail: Robert.Norton@health.qld.gov.au. Bart J. Currie, Royal Darwin Hospital, Darwin, NT, Australia and Menzies School of Health Research, Darwin, NT, Australia, E-mail: bart.currie@menzies.edu.au.

Reprint requests: Bart J. Currie, Menzies School of Health Research, PO Box 41096, Darwin, Northern Territory 0811, Australia, E-mail: bart.currie@menzies.edu.au.

  • 1.

    Wiersinga WJ, Currie BJ, Peacock SJ, 2012. Melioidosis. N Engl J Med 367: 10351044.

  • 2.

    Dance DA, 2015. Editorial commentary: melioidosis in Puerto Rico: the iceberg slowly emerges. Clin Infect Dis 60: 251253.

  • 3.

    Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ, 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 11131117.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Lo TJ, Ang LW, James L, Goh KT, 2009. Melioidosis in a tropical city state, Singapore. Emerg Infect Dis 15: 16451647.

  • 5.

    Parameswaran U, Baird RW, Ward LM, Currie BJ, 2012. Melioidosis at Royal Darwin Hospital in the big 2009–2010 wet season: comparison with the preceding 20 years. Med J Aust 196: 345348.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Kaestli M, Mayo M, Harrington G, Ward L, Watt F, Hill JV, Cheng AC, Currie BJ, 2009. Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia. PLoS Negl Trop Dis 3: e364.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Limmathurotsakul D, Kanoksil M, Wuthiekanun V, Kitphati R, Destavola B, Day NP, Peacock SJ, 2013. Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis 7: e2072.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Currie BJ, Ward L, Cheng AC, 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Gibney KB, Cheng AC, Currie BJ, 2008. Cutaneous melioidosis in the tropical top end of Australia: a prospective study and review of the literature. Clin Infect Dis 47: 603609.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    McLeod C, Morris PS, Bauert PA, Kilburn CJ, Ward LM, Baird RW, Currie BJ, 2015. Clinical presentation and medical management of melioidosis in children: a 24-year prospective study in the Northern Territory of Australia and review of the literature. Clin Infect Dis 60: 2126.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    James GL, Delaney B, Ward L, Freeman K, Mayo M, Currie BJ, 2013. Surprisingly low seroprevalence of Burkholderia pseudomallei in exposed healthy adults in the Darwin region of tropical Australia where melioidosis is highly endemic. Clin Vaccine Immunol 20: 759760.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Cheng AC, O'Brien M, Freeman K, Lum G, Currie BJ, 2006. Indirect hemagglutination assay in patients with melioidosis in Northern Australia. Am J Trop Med Hyg 74: 330334.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Harris PN, Williams NL, Morris JL, Ketheesan N, Norton RE, 2011. Evidence of Burkholderia pseudomallei-specific immunity in patient sera persistently nonreactive by the indirect hemagglutination assay. Clin Vaccine Immunol 18: 12881291.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Hill AA, Mayo M, Kaestli M, Price EP, Richardson LJ, Godoy D, Spratt BG, Currie BJ, 2013. Melioidosis as a consequence of sporting activity. Am J Trop Med Hyg 89: 365366.

  • 15.

    Wuthiekanun V, Chierakul W, Langa S, Chaowagul W, Panpitpat C, Saipan P, Thoujaikong T, Day NP, Peacock SJ, 2006. Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand. Am J Trop Med Hyg 74: 10741075.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Cheng AC, Wuthiekanun V, Limmathurotsakul D, Chierakul W, Peacock SJ, 2008. Intensity of exposure and incidence of melioidosis in Thai children. Trans R Soc Trop Med Hyg 102 (Suppl 1): S37S39.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Sapian M, Khairi MT, How SH, Rajalingam R, Sahhir K, Norazah A, Khebir V, Jamalludin AR, 2012. Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. Med J Malaysia 67: 293297.

    • PubMed
    • Search Google Scholar
    • Export Citation
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