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Isolation and Characterization of Mayaro Virus from a Human in Acre, Brazil

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  • Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil; Institute for Human Infections and Immunity, Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Instituto de Ciências Biológicas/Universidade de São Paulo, São Paulo, Brazil; Universidade Federal do ABC, Santo André, São Paulo, Brazil; Universidade Estadual Paulista, Botucatu, São Paulo, Brazil

Mayaro virus (MAYV) is widely distributed throughout South America and is the etiologic agent of Mayaro fever, an acute febrile illness often presenting with arthralgic manifestations. The true incidence of MAYV infection is likely grossly underestimated because the symptomatic presentation is very similar to that of dengue fever and other acute febrile tropical diseases. We report the complete genome sequence of a MAYV isolate detected from an Acrelândia patient presenting with fever, chills, and sweating, but with no arthralgia. Results show that this isolate belongs to genotype D and is closely related to Bolivian strains. Our results suggest that the Acre/Mayaro strain is closely related to the progenitor of these Bolivian strains that were isolated between 2002 and 2006.

Author Notes

* Address correspondence to Maurício L. Nogueira, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil. E-mail: mnogueira@famerp.br

Financial support: This work was supported by INCT-Dengue and FAPESP (grant no. 2012/11733-6 to MLN). AJA was supported by the James W. McLaughlin Endowment fund.

Authors' addresses: Ana Carolina B. Terzian, Danila Vedovello, and Maurício L. Nogueira, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil, E-mails: anacarolinaterzian@gmail.com, danvedo@hotmail.com, and mnogueira@famerp.br. Albert J. Auguste and Scott C. Weaver, Institute for Human Infections and Immunity and Department of Pathology, University of Texas Medical Branch, Galveston, TX, E-mails: aj1augus@utmb.edu and sweaver@utmb.edu. Marcelo U. Ferreira and Monica da Silva-Nunes, Instituto de Ciências Biológicas/Universidade de São Paulo, São Paulo, Brazil, E-mails: muferrei@gmail.com and msnunes1@yahoo.com.br. Márcia A. Sperança, Rodrigo B. Suzuki, and Camila Juncansen, Universidade Federal do ABC, Santo André, São Paulo, Brazil, E-mails: speranca@yahoo.com, rbsuzuki@gmail.com, and camilacj@yahoo.com.br. João P. Araújo Jr., Universidade Estadual Paulista, Botucatu, São Paulo, Brazil, E-mail: jpessoa@ibb.unesp.br.

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