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Two Cases of False-Positive Dengue Non-Structural Protein 1 (NS1) Antigen in Patients with Hematological Malignancies and a Review of the Literature on the Use of NS1 for the Detection of Dengue Infection

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  • Department of Infectious Diseases, Singapore General Hospital, Singapore; Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore; National Public Health Laboratory, Ministry of Health, Singapore; Communicable Diseases Centre, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore; Yong Loo Lin School of Medicine, National University, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Early diagnosis of dengue has been made easier in recent years owing to the advancement in diagnostic technologies. The rapid non-structural protein 1 (NS1) test strip is widely used in many developed and developing regions at risk of dengue. Despite the relatively high specificity of this test, we recently encountered two cases of false-positive dengue NS1 antigen in patients with underlying hematological malignancies. We reviewed the literature for causes of false-positive dengue NS1.

Author Notes

* Address correspondence to Shimin J. Chung, The Academia, Singapore General Hospital, Department of Laboratory Medicine, Tan Tock Seng Hospital and Communicable Disease Centre, 20 College Road, Singapore 169856. E-mail: jasmine.chung.s.m@sgh.com.sg

Authors' addresses: Shimin J. Chung, Prabha U. Krishnan, and Yee Sin Leo, The Academia, Singapore General Hospital, Department of Laboratory Medicine, Tan Tock Seng Hospital and Communicable Disease Centre, Singapore, E-mails: jasmine.chung.s.m@sgh.com.sg, prabha_krishnan@ttsh.com.sg, and yee_sin_leo@ttsh.com.sg.

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