ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2007. Report of the Fifth Consultative Meeting on Leishmania/HIV Coinfection. Addis Ababa, Ethiopa: World Health Organization.
-
2.
Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, Lopez-Velez R, Moreno J, 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334–359.
-
3.
Dedet JP, Roche B, Pratlong F, Cales-Quist D, Jouannelle J, Benichou JC, Huerre M, 1995. Diffuse cutaneous infection caused by a presumed monoxenous trypanosomatid in a patient infected with HIV. Trans R Soc Trop Med Hyg 89: 644–646.
-
4.
Noyes H, Pratlong F, Chance M, Ellis J, Lanotte G, Dedet JP, 2002. A previously unclassified trypanosomatid responsible for human cutaneous lesions in Martinique (French West Indies) is the most divergent member of the genus Leishmania ss. Parasitology 124: 17–24.
-
5.
Desbois N, Pratlong F, Quist D, Dedet JP, 2014. Leishmania (Leishmania) martiniquensis n. sp. (Kinetoplastida: Trypanosomatidae), description of the parasite responsible for cutaneous leishmaniasis in Martinique Island (French West Indies). Parasite 21: 12.
-
6.
Liautaud B, Pape JW, DeHovitz JA, Thomas F, LaRoche AC, Verdier RI, Deschamps MM, Johnson WD, 1989. Pruritic skin lesions. A common initial presentation of acquired immunodeficiency syndrome. Arch Dermatol 125: 629–632.
-
7.
Mary C, Faraut F, Lascombe L, Dumon H, 2004. Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J Clin Microbiol 42: 5249–5255.
-
8.
Zeledon R, 1992. Leishmaniasis in the Caribbean Islands. A review. Ann N Y Acad Sci 653: 154–160.
-
9.
Garin YJ, Sulahian A, Meneceur P, Pratlong F, Prina E, Gangneux J, Dedet JP, Derouin F, 2001. Experimental pathogenicity of a presumed monoxenous trypanosomatid isolated from humans in a murine model. J Eukaryot Microbiol 48: 170–176.
-
10.
Courmes E, Escudie A, Fauran P, Monnerville A, 1966. First native case of human visceral leishmaniasis in Guadeloupe. Bull Soc Pathol Exot 59: 217–226.
-
11.
Cnudde F, Raccurt C, Boulard F, Terron-Aboud B, Nicolas M, Juminer B, 1994. Diffuse cutaneous leishmaniasis with visceral dissemination in an AIDS patient in Guadeloupe, West Indies. AIDS 8: 559–560.
-
12.
Kaplan JE, Benson C, Holmes KH, Brooks JT, Pau A, Masur H, 2009. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Recomm Rep 58: 1–207.
-
13.
Yanamandra U, Jairam A, Shankar S, Negi R, Guleria B, Nair V, 2011. Visceral leishmaniasis mimicking as second line anti retroviral therapy failure. Intern Med 50: 2855–2858.
-
14.
Cruz I, Nieto J, Moreno J, Canavate C, Desjeux P, Alvar J, 2006. Leishmania/HIV co-infections in the second decade. Indian J Med Res 123: 357–388.
-
15.
Cota GF, de Sousa MR, Rabello A, 2011. Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. PLoS Negl Trop Dis 5: e1153.
-
16.
Dedet JP, Gay F, Chatenay G, 1989. Isolation of Leishmania species from wild mammals in French Guiana. Trans R Soc Trop Med Hyg 83: 613–615.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 2426 | 2247 | 32 |
| Full Text Views | 402 | 15 | 0 |
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First Case of Visceral Leishmaniasis Caused by Leishmania martiniquensis
Bernard Liautaud
Bernard Liautaud
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Nicolas Vignier
Nicolas Vignier
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Charline Miossec
Charline Miossec
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Yves Plumelle
Yves Plumelle
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Moumini Kone
Moumini Kone
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Delphine Delta
Delphine Delta
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Christophe Ravel
Christophe Ravel
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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André Cabié
André Cabié
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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Nicole Desbois
Nicole Desbois
Department of Tropical and Infectious Disease, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Department of Tropical and Infectious Disease, University Hospital of Avicenne, Bobigny, France; Parasitology and Mycology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Laboratory, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; Hematology Unit, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies; University Hospital of Montpellier, Unité Mixte de Recherche 5290, French National Reference Center for Leishmaniasis, Montpellier, France; Faculté des Antilles et de la Guyane, Institut National de la Santé et de la Recherche Medicale CIC1424 and EA4537, Martinique, French West Indies
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We report the first case of visceral leishmaniasis (VL) caused by Leishmania martiniquensis in the Caribbean, which until now, was known only to cause cutaneous leishmaniasis. The disease presented with fatigue, anemia, and hepatosplenomegaly in a 61-year-old man with human immunodeficiency virus (HIV) infection who was receiving antiretroviral therapy. Diagnosis was made by bone marrow biopsy. VL is life-threatening, and its emergence in the Caribbean is of concern.
Author Notes
Authors' addresses: Bernard Liautaud and Nicolas Vignier, Department of Infectious and Tropical Diseases, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies, E-mails: Bliautaud1@gmail.com and vigniernicolas@yahoo.fr. Charline Miossec and Nicole Desbois, Department of Parasitology and Mycology, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies, E-mails: charlinemiossec@hotmail.fr and nicole.desbois@chu-fortdefrance.fr. Yves Plumelle, Moumini Kone, and Delphine Delta, Department of Hematology, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies, E-mails: yves.plumelle@chu-fortdefrance.fr, mt.kone@chu-fortdefrance.fr, and delphine.delta@gmail.com. Christophe Ravel, Université Montpellier 1, Montpellier, France, and Regional University Hospital of Montpellier, UMR5290, French National Reference Center for Leishmaniasis University, Hospital of Montpellier, Montpellier, France, E-mail: christophe.ravel@univ-montp1.fr. André Cabié, Department of Infectious and Tropical Diseases and Inserm CIE802, University Hospital of Fort-de-France, Fort-de-France, Martinique, French West Indies, E-mail: andre.cabie@chu-fortdefrance.fr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2007. Report of the Fifth Consultative Meeting on Leishmania/HIV Coinfection. Addis Ababa, Ethiopa: World Health Organization.
-
2.
Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, Lopez-Velez R, Moreno J, 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334–359.
-
3.
Dedet JP, Roche B, Pratlong F, Cales-Quist D, Jouannelle J, Benichou JC, Huerre M, 1995. Diffuse cutaneous infection caused by a presumed monoxenous trypanosomatid in a patient infected with HIV. Trans R Soc Trop Med Hyg 89: 644–646.
-
4.
Noyes H, Pratlong F, Chance M, Ellis J, Lanotte G, Dedet JP, 2002. A previously unclassified trypanosomatid responsible for human cutaneous lesions in Martinique (French West Indies) is the most divergent member of the genus Leishmania ss. Parasitology 124: 17–24.
-
5.
Desbois N, Pratlong F, Quist D, Dedet JP, 2014. Leishmania (Leishmania) martiniquensis n. sp. (Kinetoplastida: Trypanosomatidae), description of the parasite responsible for cutaneous leishmaniasis in Martinique Island (French West Indies). Parasite 21: 12.
-
6.
Liautaud B, Pape JW, DeHovitz JA, Thomas F, LaRoche AC, Verdier RI, Deschamps MM, Johnson WD, 1989. Pruritic skin lesions. A common initial presentation of acquired immunodeficiency syndrome. Arch Dermatol 125: 629–632.
-
7.
Mary C, Faraut F, Lascombe L, Dumon H, 2004. Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J Clin Microbiol 42: 5249–5255.
-
8.
Zeledon R, 1992. Leishmaniasis in the Caribbean Islands. A review. Ann N Y Acad Sci 653: 154–160.
-
9.
Garin YJ, Sulahian A, Meneceur P, Pratlong F, Prina E, Gangneux J, Dedet JP, Derouin F, 2001. Experimental pathogenicity of a presumed monoxenous trypanosomatid isolated from humans in a murine model. J Eukaryot Microbiol 48: 170–176.
-
10.
Courmes E, Escudie A, Fauran P, Monnerville A, 1966. First native case of human visceral leishmaniasis in Guadeloupe. Bull Soc Pathol Exot 59: 217–226.
-
11.
Cnudde F, Raccurt C, Boulard F, Terron-Aboud B, Nicolas M, Juminer B, 1994. Diffuse cutaneous leishmaniasis with visceral dissemination in an AIDS patient in Guadeloupe, West Indies. AIDS 8: 559–560.
-
12.
Kaplan JE, Benson C, Holmes KH, Brooks JT, Pau A, Masur H, 2009. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Recomm Rep 58: 1–207.
-
13.
Yanamandra U, Jairam A, Shankar S, Negi R, Guleria B, Nair V, 2011. Visceral leishmaniasis mimicking as second line anti retroviral therapy failure. Intern Med 50: 2855–2858.
-
14.
Cruz I, Nieto J, Moreno J, Canavate C, Desjeux P, Alvar J, 2006. Leishmania/HIV co-infections in the second decade. Indian J Med Res 123: 357–388.
-
15.
Cota GF, de Sousa MR, Rabello A, 2011. Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. PLoS Negl Trop Dis 5: e1153.
-
16.
Dedet JP, Gay F, Chatenay G, 1989. Isolation of Leishmania species from wild mammals in French Guiana. Trans R Soc Trop Med Hyg 83: 613–615.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2426 | 2247 | 32 |
| Full Text Views | 402 | 15 | 0 |
| PDF Downloads | 123 | 17 | 0 |