Author:
- Introduction
- Materials and Methods
- Results
- Patient characteristics.
- Characteristics of patients with rhabdomyolysis.
- Comparison of demographic, initial clinical, and laboratory features as well as image findings before occurrence of rhabdomyolysis between the study and control groups.
- Comparison of cytokine/chemokine levels between the study and control groups.
- Discussion
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization.
-
2.
World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.
-
3.
Simmons CP, Farrar JJ, Nguyen vV, Wills B, 2012. Dengue. N Engl J Med 366: 1423–1432.
-
4.
Centers for Disease Control and Prevention (CDC), 2010. Travel-associated dengue surveillance—United States, 2006–2008. MMWR Morb Mortal Wkly Rep 59: 715–719.
-
5.
Mohammed HP, Ramos MM, Rivera A, Johansson M, Muñoz-Jordan JL, Sun W, Tomashek KM, 2010. Travel-associated dengue infections in the United States, 1996 to 2005. J Travel Med 17: 8–14.
-
6.
Wilder-Smith A, Schwartz E, 2005. Dengue in travelers. N Engl J Med 353: 924–932.
-
7.
Gunasekera HH, Adikaram AV, Herath CA, Samarasinghe HH, 2000. Myoglobinuric acute renal failure following dengue viral infection. Ceylon Med J 45: 181.
-
8.
Davis JS, Bourke P, 2004. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 38: e109–e111.
-
9.
Lim M, Goh HK, 2005. Rhabdomyolysis following dengue virus infection. Singapore Med J 46: 645–646.
-
10.
Karakus A, Banga N, Voorn GP, Meinders AJ, 2007. Dengue shock syndrome and rhabdomyolysis. Neth J Med 65: 78–81.
-
11.
Acharya S, Shukla S, Mahajan SN, Diwan SK, 2010. Acute dengue myositis with rhabdomyolysis and acute renal failure. Ann Indian Acad Neurol 13: 221–222.
-
12.
Yong KP, Tan BH, Low CY, 2012. Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase. BMC Infect Dis 12: 364.
-
13.
Sunderalingam V, Kanapathipillai T, Edirisinghe PA, Dassanayake KM, Premawansa IH, 2013. Dengue viral myositis complicated with rhabdomyolysis and superinfection of methicillin-resistant Staphylococcus aureus. Case Rep Infect Dis 2013: 194205.
-
14.
Wijesinghe A, Gnanapragash N, Ranasinghe G, Ragunathan MK, 2013. Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report. J Med Case Rep 7: 195.
-
15.
Mok Y, Quah J, Siau C, 2013. A rare but potentially lethal complication of dengue. Asian Pac J Trop Med 6: 500–501.
-
16.
Jha R, Gude D, Chennamsetty S, 2013. Non-hemorrhagic dengue fever with rhabdomyolysis. Saudi J Kidney Dis Transpl 24: 1207–1209.
-
17.
Sargeant T, Harris T, Wilks R, Barned S, Galloway-Blake K, Ferguson T, 2013. Rhabdomyolysis and dengue fever: a case report and literature review. Case Rep Med 2013: 101058.
-
18.
Repizo LP, Malheiros DM, Yu L, Barros RT, Burdmann EA, 2014. Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature. Rev Inst Med Trop Sao Paulo 56: 85–88.
-
19.
Bosch X, Poch E, Grau JM, 2009. Rhabdomyolysis and acute kidney injury. N Engl J Med 361: 62–72.
-
20.
Pesik NT, Otten EJ, 1996. Severe rhabdomyolysis following a viral illness: a case report and review of the literature. J Emerg Med 14: 425–428.
-
21.
Wang YM, Zhang Y, Ye ZB, 2006. Rhabdomyolysis following recent severe coxsackie virus infection in patient with chronic renal failure: one case report and a review of the literature. Ren Fail 28: 89–93.
-
22.
Singh U, Scheld WM, 1996. Infectious etiologies of rhabdomyolysis: three case reports and review. Clin Infect Dis 22: 642–649.
-
23.
Leebeek FW, Baggen MG, Mulder LJ, Dingemans-Dumas AM, 1995. Rhabdomyolysis associated with influenza A virus infection. Neth J Med 46: 189–192.
-
24.
Tanaka T, Takada T, Takagi D, Takeyama N, Kitazawa Y, 1989. Acute renal failure due to rhabdomyolysis associated with echovirus 9 infection: a case report and review of literature. Jpn J Med 28: 237–242.
-
25.
Lee IK, Liu JW, Yang KD, 2012. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis 6: e1532.
-
26.
Bagley WH, Yang H, Shah KH, 2007. Rhabdomyolysis. Intern Emerg Med 2: 210–218.
-
27.
Lane R, Philps M, 2003. Rhabdomyolysis has many causes, including statins, and may be fatal. BMJ 327: 115–116.
-
28.
Sauret JM, Marinides G, Wang GK, 2002. Rhabdomyolysis. Am Fam Physician 65: 907–912.
-
29.
Ravindra LM, John AK, Sudhir VS, Bruce AM, Claudio R, David GW, Adeera L; Acute Kidney Injury Network, 2007. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31.
-
30.
Lee IK, Hsieh CJ, Chen RF, Yang ZS, Wang L, Chen CM, Liu CF, Huang CH, Lin CY, Chen YH, Yang KD, Liu JW, 2013. Increased production of interleukin-4, interleukin-10, and granulocyte-macrophage colony-stimulating factor by type 2 diabetes' mononuclear cells infected with dengue virus, but not increased intracellular viral multiplication. Biomed Res Int 2013: 965853.
-
31.
Moncunill G, Aponte JJ, Nhabomba AJ, Dobaño C, 2013. Performance of multiplex commercial kits to quantify cytokine and chemokine responses in culture supernatants from Plasmodium falciparum stimulations. PLoS ONE 8: e52587.
-
32.
Shu PY, Yang CF, Su CL, Chen CY, Chang SF, Tsai KH, Cheng CH, Huang JH, 2008. Two imported chikungunya cases, Taiwan. Emerg Infect Dis 14: 1326–1327.
-
33.
Chang K, Hsieh HC, Tsai JJ, Lin WR, Lu PL, Chen YH, 2010. Diagnosis and management of imported Chikungunya fever in Taiwan: a case report. Kaohsiung J Med Sci 26: 256–260.
-
34.
Efstratiadis G, Voulgaridou A, Nikiforou D, Kyventidis A, Kourkouni E, Vergoulas G, 2007. Rhabdomyolysis updated. Hippokratia 11: 129–137.
-
35.
Pang J, Salim A, Lee VJ, Hibberd ML, Chia KS, Leo YS, Lye DC, 2012. Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. PLoS Negl Trop Dis 6: e1641.
-
36.
Figueiredo MA, Rodrigues LC, Barreto ML, Lima JW, Costa MC, Morato V, Blanton R, Vasconcelos PF, Nunes MR, Teixeira MG, 2010. Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. PLoS Negl Trop Dis 4: e699.
-
37.
Kuo MC, Lu PL, Chang JM, Lin MY, Tsai JJ, Chen YH, Chang K, Chen HC, Hwang SJ, 2008. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol 3: 1350–1356.
-
38.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee, 2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206–1252.
-
39.
Ward MM, 1988. Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med 148: 1553–1557.
-
40.
Gulati S, Maheshwari A, 2007. Atypical manifestations of dengue. Trop Med Int Health 12: 1087–1095.
-
41.
Rigau-Pérez JG, 2006. Severe dengue: the need for new case definitions. Lancet Infect Dis 6: 297–302.
-
42.
Yen YT, Chen HC, Lin YD, Shieh CC, Wu-Hsieh BA, 2008. Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development. J Virol 82: 12312–12324.
-
43.
Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A, 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315–325.
-
44.
Pedersen BK, Febbraio MA, 2008. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 88: 1379–1406.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 850 | 710 | 35 |
| Full Text Views | 398 | 16 | 2 |
| PDF Downloads | 141 | 15 | 0 |
Clinical Features of and Risk Factors for Rhabdomyolysis Among Adult Patients with Dengue Virus Infection
Shi-Yu Huang
Shi-Yu Huang
Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Ing-Kit Lee
Ing-Kit Lee
Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Jien-Wei Liu
Jien-Wei Liu
Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Chia-Te Kung
Chia-Te Kung
Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Lin Wang
Lin Wang
Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Among 1,076 dengue patients, 9 patients with rhabdomyolysis and 1,067 patients without rhabdomyolysis (controls) were retrospectively analyzed. Of nine patients with rhabdomyolysis, the most commonly reported symptom other than fever was myalgia; dengue hemorrhagic fever (DHF) was found in seven cases, and acute kidney injury was found in six cases. Furthermore, one (11.1%) patient died. The median duration from hospital admission to rhabdomyolysis diagnosis was 3 days. Patients with rhabdomyolysis had higher age, proportion of men, prevalence of hypertension, frequency of myalgia, and incidences of DHF, pleural effusion, and acute kidney injury than controls. Multivariate analysis showed that hypertension (odds ratio [OR] = 14.270), myalgia (OR = 20.377), and acute kidney injury (OR = 65.547) were independent risk factors for rhabdomyolysis. Comparison of cytokine/chemokine concentrations in 101 DHF patients, including those with (N = 4) and without (N = 97) rhabdomyolysis, showed that interleukin-6 and tumor necrosis factor-α levels were significantly increased in the former.
Author Notes
Financial support: This work was partly supported by Grant NSC 100-2314-B-182-002-MY3 from the National Science Council, Executive Yuan, Taiwan, Republic of China.
Authors' addresses: Shi-Yu Huang and Chia-Te Kung, Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, E-mails: sarawah@ms28.hinet.net and g00308@cgmh.org.tw. Ing-Kit Lee and Jien-Wei Liu, Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan and Chang Gung University College of Medicine, Kaohsiung, Taiwan, E-mails: leee@cgmh.org.tw and jwliu@cgmh.org.tw. Lin Wang, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, E-mail: ling6422@yahoo.com.tw2.
- Introduction
- Materials and Methods
- Results
- Patient characteristics.
- Characteristics of patients with rhabdomyolysis.
- Comparison of demographic, initial clinical, and laboratory features as well as image findings before occurrence of rhabdomyolysis between the study and control groups.
- Comparison of cytokine/chemokine levels between the study and control groups.
- Discussion
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization.
-
2.
World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.
-
3.
Simmons CP, Farrar JJ, Nguyen vV, Wills B, 2012. Dengue. N Engl J Med 366: 1423–1432.
-
4.
Centers for Disease Control and Prevention (CDC), 2010. Travel-associated dengue surveillance—United States, 2006–2008. MMWR Morb Mortal Wkly Rep 59: 715–719.
-
5.
Mohammed HP, Ramos MM, Rivera A, Johansson M, Muñoz-Jordan JL, Sun W, Tomashek KM, 2010. Travel-associated dengue infections in the United States, 1996 to 2005. J Travel Med 17: 8–14.
-
6.
Wilder-Smith A, Schwartz E, 2005. Dengue in travelers. N Engl J Med 353: 924–932.
-
7.
Gunasekera HH, Adikaram AV, Herath CA, Samarasinghe HH, 2000. Myoglobinuric acute renal failure following dengue viral infection. Ceylon Med J 45: 181.
-
8.
Davis JS, Bourke P, 2004. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 38: e109–e111.
-
9.
Lim M, Goh HK, 2005. Rhabdomyolysis following dengue virus infection. Singapore Med J 46: 645–646.
-
10.
Karakus A, Banga N, Voorn GP, Meinders AJ, 2007. Dengue shock syndrome and rhabdomyolysis. Neth J Med 65: 78–81.
-
11.
Acharya S, Shukla S, Mahajan SN, Diwan SK, 2010. Acute dengue myositis with rhabdomyolysis and acute renal failure. Ann Indian Acad Neurol 13: 221–222.
-
12.
Yong KP, Tan BH, Low CY, 2012. Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase. BMC Infect Dis 12: 364.
-
13.
Sunderalingam V, Kanapathipillai T, Edirisinghe PA, Dassanayake KM, Premawansa IH, 2013. Dengue viral myositis complicated with rhabdomyolysis and superinfection of methicillin-resistant Staphylococcus aureus. Case Rep Infect Dis 2013: 194205.
-
14.
Wijesinghe A, Gnanapragash N, Ranasinghe G, Ragunathan MK, 2013. Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report. J Med Case Rep 7: 195.
-
15.
Mok Y, Quah J, Siau C, 2013. A rare but potentially lethal complication of dengue. Asian Pac J Trop Med 6: 500–501.
-
16.
Jha R, Gude D, Chennamsetty S, 2013. Non-hemorrhagic dengue fever with rhabdomyolysis. Saudi J Kidney Dis Transpl 24: 1207–1209.
-
17.
Sargeant T, Harris T, Wilks R, Barned S, Galloway-Blake K, Ferguson T, 2013. Rhabdomyolysis and dengue fever: a case report and literature review. Case Rep Med 2013: 101058.
-
18.
Repizo LP, Malheiros DM, Yu L, Barros RT, Burdmann EA, 2014. Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature. Rev Inst Med Trop Sao Paulo 56: 85–88.
-
19.
Bosch X, Poch E, Grau JM, 2009. Rhabdomyolysis and acute kidney injury. N Engl J Med 361: 62–72.
-
20.
Pesik NT, Otten EJ, 1996. Severe rhabdomyolysis following a viral illness: a case report and review of the literature. J Emerg Med 14: 425–428.
-
21.
Wang YM, Zhang Y, Ye ZB, 2006. Rhabdomyolysis following recent severe coxsackie virus infection in patient with chronic renal failure: one case report and a review of the literature. Ren Fail 28: 89–93.
-
22.
Singh U, Scheld WM, 1996. Infectious etiologies of rhabdomyolysis: three case reports and review. Clin Infect Dis 22: 642–649.
-
23.
Leebeek FW, Baggen MG, Mulder LJ, Dingemans-Dumas AM, 1995. Rhabdomyolysis associated with influenza A virus infection. Neth J Med 46: 189–192.
-
24.
Tanaka T, Takada T, Takagi D, Takeyama N, Kitazawa Y, 1989. Acute renal failure due to rhabdomyolysis associated with echovirus 9 infection: a case report and review of literature. Jpn J Med 28: 237–242.
-
25.
Lee IK, Liu JW, Yang KD, 2012. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis 6: e1532.
-
26.
Bagley WH, Yang H, Shah KH, 2007. Rhabdomyolysis. Intern Emerg Med 2: 210–218.
-
27.
Lane R, Philps M, 2003. Rhabdomyolysis has many causes, including statins, and may be fatal. BMJ 327: 115–116.
-
28.
Sauret JM, Marinides G, Wang GK, 2002. Rhabdomyolysis. Am Fam Physician 65: 907–912.
-
29.
Ravindra LM, John AK, Sudhir VS, Bruce AM, Claudio R, David GW, Adeera L; Acute Kidney Injury Network, 2007. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31.
-
30.
Lee IK, Hsieh CJ, Chen RF, Yang ZS, Wang L, Chen CM, Liu CF, Huang CH, Lin CY, Chen YH, Yang KD, Liu JW, 2013. Increased production of interleukin-4, interleukin-10, and granulocyte-macrophage colony-stimulating factor by type 2 diabetes' mononuclear cells infected with dengue virus, but not increased intracellular viral multiplication. Biomed Res Int 2013: 965853.
-
31.
Moncunill G, Aponte JJ, Nhabomba AJ, Dobaño C, 2013. Performance of multiplex commercial kits to quantify cytokine and chemokine responses in culture supernatants from Plasmodium falciparum stimulations. PLoS ONE 8: e52587.
-
32.
Shu PY, Yang CF, Su CL, Chen CY, Chang SF, Tsai KH, Cheng CH, Huang JH, 2008. Two imported chikungunya cases, Taiwan. Emerg Infect Dis 14: 1326–1327.
-
33.
Chang K, Hsieh HC, Tsai JJ, Lin WR, Lu PL, Chen YH, 2010. Diagnosis and management of imported Chikungunya fever in Taiwan: a case report. Kaohsiung J Med Sci 26: 256–260.
-
34.
Efstratiadis G, Voulgaridou A, Nikiforou D, Kyventidis A, Kourkouni E, Vergoulas G, 2007. Rhabdomyolysis updated. Hippokratia 11: 129–137.
-
35.
Pang J, Salim A, Lee VJ, Hibberd ML, Chia KS, Leo YS, Lye DC, 2012. Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. PLoS Negl Trop Dis 6: e1641.
-
36.
Figueiredo MA, Rodrigues LC, Barreto ML, Lima JW, Costa MC, Morato V, Blanton R, Vasconcelos PF, Nunes MR, Teixeira MG, 2010. Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. PLoS Negl Trop Dis 4: e699.
-
37.
Kuo MC, Lu PL, Chang JM, Lin MY, Tsai JJ, Chen YH, Chang K, Chen HC, Hwang SJ, 2008. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol 3: 1350–1356.
-
38.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee, 2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206–1252.
-
39.
Ward MM, 1988. Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med 148: 1553–1557.
-
40.
Gulati S, Maheshwari A, 2007. Atypical manifestations of dengue. Trop Med Int Health 12: 1087–1095.
-
41.
Rigau-Pérez JG, 2006. Severe dengue: the need for new case definitions. Lancet Infect Dis 6: 297–302.
-
42.
Yen YT, Chen HC, Lin YD, Shieh CC, Wu-Hsieh BA, 2008. Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development. J Virol 82: 12312–12324.
-
43.
Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A, 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315–325.
-
44.
Pedersen BK, Febbraio MA, 2008. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 88: 1379–1406.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 850 | 710 | 35 |
| Full Text Views | 398 | 16 | 2 |
| PDF Downloads | 141 | 15 | 0 |