• 1.

    World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: World Health Organization.

    • Search Google Scholar
    • Export Citation
  • 2.

    World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.

  • 3.

    Simmons CP, Farrar JJ, Nguyen vV, Wills B, 2012. Dengue. N Engl J Med 366: 14231432.

  • 4.

    Centers for Disease Control and Prevention (CDC), 2010. Travel-associated dengue surveillance—United States, 2006–2008. MMWR Morb Mortal Wkly Rep 59: 715719.

    • Search Google Scholar
    • Export Citation
  • 5.

    Mohammed HP, Ramos MM, Rivera A, Johansson M, Muñoz-Jordan JL, Sun W, Tomashek KM, 2010. Travel-associated dengue infections in the United States, 1996 to 2005. J Travel Med 17: 814.

    • Search Google Scholar
    • Export Citation
  • 6.

    Wilder-Smith A, Schwartz E, 2005. Dengue in travelers. N Engl J Med 353: 924932.

  • 7.

    Gunasekera HH, Adikaram AV, Herath CA, Samarasinghe HH, 2000. Myoglobinuric acute renal failure following dengue viral infection. Ceylon Med J 45: 181.

    • Search Google Scholar
    • Export Citation
  • 8.

    Davis JS, Bourke P, 2004. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 38: e109e111.

  • 9.

    Lim M, Goh HK, 2005. Rhabdomyolysis following dengue virus infection. Singapore Med J 46: 645646.

  • 10.

    Karakus A, Banga N, Voorn GP, Meinders AJ, 2007. Dengue shock syndrome and rhabdomyolysis. Neth J Med 65: 7881.

  • 11.

    Acharya S, Shukla S, Mahajan SN, Diwan SK, 2010. Acute dengue myositis with rhabdomyolysis and acute renal failure. Ann Indian Acad Neurol 13: 221222.

    • Search Google Scholar
    • Export Citation
  • 12.

    Yong KP, Tan BH, Low CY, 2012. Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase. BMC Infect Dis 12: 364.

    • Search Google Scholar
    • Export Citation
  • 13.

    Sunderalingam V, Kanapathipillai T, Edirisinghe PA, Dassanayake KM, Premawansa IH, 2013. Dengue viral myositis complicated with rhabdomyolysis and superinfection of methicillin-resistant Staphylococcus aureus. Case Rep Infect Dis 2013: 194205.

    • Search Google Scholar
    • Export Citation
  • 14.

    Wijesinghe A, Gnanapragash N, Ranasinghe G, Ragunathan MK, 2013. Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report. J Med Case Rep 7: 195.

    • Search Google Scholar
    • Export Citation
  • 15.

    Mok Y, Quah J, Siau C, 2013. A rare but potentially lethal complication of dengue. Asian Pac J Trop Med 6: 500501.

  • 16.

    Jha R, Gude D, Chennamsetty S, 2013. Non-hemorrhagic dengue fever with rhabdomyolysis. Saudi J Kidney Dis Transpl 24: 12071209.

  • 17.

    Sargeant T, Harris T, Wilks R, Barned S, Galloway-Blake K, Ferguson T, 2013. Rhabdomyolysis and dengue fever: a case report and literature review. Case Rep Med 2013: 101058.

    • Search Google Scholar
    • Export Citation
  • 18.

    Repizo LP, Malheiros DM, Yu L, Barros RT, Burdmann EA, 2014. Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature. Rev Inst Med Trop Sao Paulo 56: 8588.

    • Search Google Scholar
    • Export Citation
  • 19.

    Bosch X, Poch E, Grau JM, 2009. Rhabdomyolysis and acute kidney injury. N Engl J Med 361: 6272.

  • 20.

    Pesik NT, Otten EJ, 1996. Severe rhabdomyolysis following a viral illness: a case report and review of the literature. J Emerg Med 14: 425428.

    • Search Google Scholar
    • Export Citation
  • 21.

    Wang YM, Zhang Y, Ye ZB, 2006. Rhabdomyolysis following recent severe coxsackie virus infection in patient with chronic renal failure: one case report and a review of the literature. Ren Fail 28: 8993.

    • Search Google Scholar
    • Export Citation
  • 22.

    Singh U, Scheld WM, 1996. Infectious etiologies of rhabdomyolysis: three case reports and review. Clin Infect Dis 22: 642649.

  • 23.

    Leebeek FW, Baggen MG, Mulder LJ, Dingemans-Dumas AM, 1995. Rhabdomyolysis associated with influenza A virus infection. Neth J Med 46: 189192.

  • 24.

    Tanaka T, Takada T, Takagi D, Takeyama N, Kitazawa Y, 1989. Acute renal failure due to rhabdomyolysis associated with echovirus 9 infection: a case report and review of literature. Jpn J Med 28: 237242.

    • Search Google Scholar
    • Export Citation
  • 25.

    Lee IK, Liu JW, Yang KD, 2012. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis 6: e1532.

    • Search Google Scholar
    • Export Citation
  • 26.

    Bagley WH, Yang H, Shah KH, 2007. Rhabdomyolysis. Intern Emerg Med 2: 210218.

  • 27.

    Lane R, Philps M, 2003. Rhabdomyolysis has many causes, including statins, and may be fatal. BMJ 327: 115116.

  • 28.

    Sauret JM, Marinides G, Wang GK, 2002. Rhabdomyolysis. Am Fam Physician 65: 907912.

  • 29.

    Ravindra LM, John AK, Sudhir VS, Bruce AM, Claudio R, David GW, Adeera L; Acute Kidney Injury Network, 2007. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31.

    • Search Google Scholar
    • Export Citation
  • 30.

    Lee IK, Hsieh CJ, Chen RF, Yang ZS, Wang L, Chen CM, Liu CF, Huang CH, Lin CY, Chen YH, Yang KD, Liu JW, 2013. Increased production of interleukin-4, interleukin-10, and granulocyte-macrophage colony-stimulating factor by type 2 diabetes' mononuclear cells infected with dengue virus, but not increased intracellular viral multiplication. Biomed Res Int 2013: 965853.

    • Search Google Scholar
    • Export Citation
  • 31.

    Moncunill G, Aponte JJ, Nhabomba AJ, Dobaño C, 2013. Performance of multiplex commercial kits to quantify cytokine and chemokine responses in culture supernatants from Plasmodium falciparum stimulations. PLoS ONE 8: e52587.

    • Search Google Scholar
    • Export Citation
  • 32.

    Shu PY, Yang CF, Su CL, Chen CY, Chang SF, Tsai KH, Cheng CH, Huang JH, 2008. Two imported chikungunya cases, Taiwan. Emerg Infect Dis 14: 13261327.

  • 33.

    Chang K, Hsieh HC, Tsai JJ, Lin WR, Lu PL, Chen YH, 2010. Diagnosis and management of imported Chikungunya fever in Taiwan: a case report. Kaohsiung J Med Sci 26: 256260.

    • Search Google Scholar
    • Export Citation
  • 34.

    Efstratiadis G, Voulgaridou A, Nikiforou D, Kyventidis A, Kourkouni E, Vergoulas G, 2007. Rhabdomyolysis updated. Hippokratia 11: 129137.

  • 35.

    Pang J, Salim A, Lee VJ, Hibberd ML, Chia KS, Leo YS, Lye DC, 2012. Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. PLoS Negl Trop Dis 6: e1641.

    • Search Google Scholar
    • Export Citation
  • 36.

    Figueiredo MA, Rodrigues LC, Barreto ML, Lima JW, Costa MC, Morato V, Blanton R, Vasconcelos PF, Nunes MR, Teixeira MG, 2010. Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. PLoS Negl Trop Dis 4: e699.

    • Search Google Scholar
    • Export Citation
  • 37.

    Kuo MC, Lu PL, Chang JM, Lin MY, Tsai JJ, Chen YH, Chang K, Chen HC, Hwang SJ, 2008. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol 3: 13501356.

    • Search Google Scholar
    • Export Citation
  • 38.

    Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee, 2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 12061252.

    • Search Google Scholar
    • Export Citation
  • 39.

    Ward MM, 1988. Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med 148: 15531557.

  • 40.

    Gulati S, Maheshwari A, 2007. Atypical manifestations of dengue. Trop Med Int Health 12: 10871095.

  • 41.

    Rigau-Pérez JG, 2006. Severe dengue: the need for new case definitions. Lancet Infect Dis 6: 297302.

  • 42.

    Yen YT, Chen HC, Lin YD, Shieh CC, Wu-Hsieh BA, 2008. Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development. J Virol 82: 1231212324.

    • Search Google Scholar
    • Export Citation
  • 43.

    Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, Faggioni R, Luini W, van Hinsbergh V, Sozzani S, Bussolino F, Poli V, Ciliberto G, Mantovani A, 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6: 315325.

    • Search Google Scholar
    • Export Citation
  • 44.

    Pedersen BK, Febbraio MA, 2008. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 88: 13791406.

Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 191 108 3
PDF Downloads 65 34 2
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Clinical Features of and Risk Factors for Rhabdomyolysis Among Adult Patients with Dengue Virus Infection

View More View Less
  • Department of Emergency Medicine, Division of Infectious Diseases, Department of Internal Medicine, Department of Pediatric, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan
Restricted access

Among 1,076 dengue patients, 9 patients with rhabdomyolysis and 1,067 patients without rhabdomyolysis (controls) were retrospectively analyzed. Of nine patients with rhabdomyolysis, the most commonly reported symptom other than fever was myalgia; dengue hemorrhagic fever (DHF) was found in seven cases, and acute kidney injury was found in six cases. Furthermore, one (11.1%) patient died. The median duration from hospital admission to rhabdomyolysis diagnosis was 3 days. Patients with rhabdomyolysis had higher age, proportion of men, prevalence of hypertension, frequency of myalgia, and incidences of DHF, pleural effusion, and acute kidney injury than controls. Multivariate analysis showed that hypertension (odds ratio [OR] = 14.270), myalgia (OR = 20.377), and acute kidney injury (OR = 65.547) were independent risk factors for rhabdomyolysis. Comparison of cytokine/chemokine concentrations in 101 DHF patients, including those with (N = 4) and without (N = 97) rhabdomyolysis, showed that interleukin-6 and tumor necrosis factor-α levels were significantly increased in the former.

Author Notes

* Address correspondence to Ing-Kit Lee, Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. E-mail: leee@cgmh.org.tw

Financial support: This work was partly supported by Grant NSC 100-2314-B-182-002-MY3 from the National Science Council, Executive Yuan, Taiwan, Republic of China.

Authors' addresses: Shi-Yu Huang and Chia-Te Kung, Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, E-mails: sarawah@ms28.hinet.net and g00308@cgmh.org.tw. Ing-Kit Lee and Jien-Wei Liu, Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan and Chang Gung University College of Medicine, Kaohsiung, Taiwan, E-mails: leee@cgmh.org.tw and jwliu@cgmh.org.tw. Lin Wang, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, E-mail: ling6422@yahoo.com.tw2.

Save