• 1.

    Mahajan SK, 2011. Gastro-intestinal bleeding in scrub typhus. J Assoc Physicians India 59: 602.

  • 2.

    Bae KB, Youn WH, Lee YJ, Jung SJ, Hong KH, 2010. Massive small bowel bleeding caused by scrub typhus in Korea. World J Gastrointest Surg 7: 4750.

  • 3.

    Hoshino C, Narita M, Yamabe A, Sekikawa Y, Ishihara K, Ikeda H, Satoh N, Inoue M, 2011. Scrub typhus-induced serious gastric ulcer bleeding. Intern Med 50: 26752677.

    • Search Google Scholar
    • Export Citation
  • 4.

    Aung-Thu, Supanaranond W, Phumiratanaprapin W, Phonrat B, Chinprasatsak S, Ratanajaratroj N, 2004. Gastrointestinal manifestations of septic patients with scrub typhus in Maharat Nakhon Ratchasima Hospital. Southeast Asian J Trop Med Public Health 35: 845851.

    • Search Google Scholar
    • Export Citation
  • 5.

    Kim SJ, Chung IK, Chung IS, Song DH, Park SH, Kim HS, Lee MH, 2000. The clinical significance of upper gastrointestinal endoscopy in gastrointestinal vasculitis related to scrub typhus. Endoscopy 32: 950955.

    • Search Google Scholar
    • Export Citation
  • 6.

    Evangelista S, 2006. Role of sensory neurons in restitution and healing of gastric ulcers. Curr Pharm Des 12: 29772984.

  • 7.

    Robinson DM, Brown G, Gan E, Huxsoll DL, 1976. Adaptation of a microimmunofluorescence test to the study of human Rickettsia tsutsugamushi antibody. Am J Trop Med Hyg 25: 900905.

    • Search Google Scholar
    • Export Citation
  • 8.

    Holzer P, Pabst MA, 1999. Visceral afferent neurons: role in gastric mucosal protection. News Physiol Sci 14: 201206.

  • 9.

    Nilsson K, Wallménius K, Hartwig S, Norlander T, Påhlson C, 2014. Bell's palsy and sudden deafness associated with Rickettsia spp. infection in Sweden. A retrospective and prospective serological survey including PCR findings. Eur J Neurol 21: 206214.

    • Search Google Scholar
    • Export Citation
  • 10.

    Premaratna R, Chandrasena TG, Dassayake AS, Loftis AD, Dasch GA, de Silva HJ, 2006. Acute hearing loss due to scrub typhus: a forgotten complication of a reemerging disease. Clin Infect Dis 42: e6e8.

    • Search Google Scholar
    • Export Citation
 
 
 
 

 

 
 
 

 

 

 

 

 

 

Neuritis and Gastrointestinal Hemorrhage in Scrub Typhus Patients

View More View Less
  • Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Republic of Korea; Department of Pathology, Chosun University College of Medicine, Gwangju, Republic of Korea

A 78-year-old woman with scrub typhus exhibited gastric hemorrhage with multiple gastric ulcers. This is the first report to confirm pathologically the presence of not only vasculitis but also, neuritis. The results suggest the necessity of studies confirming neuritis as the cause of gastric ulcer and bleeding in scrub typhus.

Author Notes

* Address correspondence to Sung-Chul Lim, Department of Pathology, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea. E-mail: sclim@chosun.ac.kr† These authors contributed equally.

Financial support: This study was supported by research funds from Chosun University (2013).

Authors' addresses: Dong-Min Kim and Na Ra Yun, Department of Internal Medicine, Chosun University School of Medicine, Gwangju, Republic of Korea, E-mails: drongkim@chosun.ac.kr and shine@chosun.ac.kr. Sung-Chul Lim, Department of Pathology, Chosun University School of Medicine, Gwangju, Republic of Korea, E-mail: sclim@chosun.ac.kr.

Reprint requests: Dong-Min Kim, Division of Infectious Diseases, Department of Internal Medicine, Chosun University School of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea, E-mail: drongkim@chosun.ac.kr.

Save