ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Woods SP, Moore DJ, Weber E, Grant I, 2009. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19: 152–168.
-
2.
Beard J, Feeley F, Rosen S, 2009. Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review. AIDS Care 21: 1343–1356.
-
3.
Joska JA, Gouse H, Paul RH, Stein DJ, Flisher AJ, 2010. Does highly active antiretroviral therapy improve neurocognitive function? A systematic review. J Neurovirol 16: 101–114.
-
4.
Holguin A, Banda M, Willen EJ, Malama C, Chiyenu KO, Mudenda VC, Wood C, 2011. HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behav 15: 1895–1901.
-
5.
Sacktor N, Nakasujja N, Okonkwo O, Skolasky RL, Robertson K, Musisi S, Katabira E, 2013. Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda. J Neurovirol 19: 48–56.
-
6.
Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, McArthur JC, Ronald A, Sacktor N, 2007. Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68: 350–355.
-
7.
Kvalsund MP, Haworth A, Murman DL, Velie E, Birbeck GL, 2009. Closing gaps in antiretroviral therapy access: human immunodeficiency virus-associated dementia screening instruments for non-physician healthcare workers. Am J Trop Med Hyg 80: 1054–1059.
-
8.
Birbeck GL, Kvalsund MP, Byers PA, Bradbury R, Mang'ombe C, Organek N, Kaile T, Sinyama AM, Sinyangwe SS, Malama K, Malama C, 2011. Neuropsychiatric and socioeconomic status impact antiretroviral adherence and mortality in rural Zambia. Am J Trop Med Hyg 85: 782–789.
-
9.
Habib AG, Yakasai AM, Owolabi LF, Ibrahim A, Habib ZG, Gudaji M, Karaye KM, Ibrahim DA, Nashabaru I, 2013. Neurocognitive impairment in HIV-1-infected adults in sub-Saharan Africa: a systematic review and meta-analysis. Int J Infect Dis 17: e820–e831.
-
10.
Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N, 2004. Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort. Neurology 63: 822–827.
-
11.
Fischer-Smith T, Croul S, Sverstiuk AE, Capini C, L'Heureux D, Regulier EG, Richardson MW, Amini S, Morgello S, Khalili K, Rappaport J, 2001. CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection. J Neurovirol 7: 528–541.
-
12.
Cettomai D, Kwasa J, Birbeck GL, Price RW, Bukusi EA, Meyer AC, 2011. Training needs and evaluation of a neuro-HIV training module for non-physician healthcare workers in western Kenya. J Neurol Sci 307: 92–96.
-
13.
Kellinghaus C, Engbring C, Kovac S, Moddel G, Boesebeck F, Fischera M, Anneken K, Klonne K, Reichelt D, Evers S, Husstedt IW, 2008. Frequency of seizures and epilepsy in neurological HIV-infected patients. Seizure 17: 27–33.
-
14.
Garg RK, 1999. HIV infection and seizures. Postgrad Med J 75: 387–390.
-
15.
Birbeck G, Chomba E, Ddumba E, Kauye F, Mielke J, 2007. Lack of appropriate treatment for people with comorbid HIV/AIDS and epilepsy in sub-Saharan Africa. Epilepsia 48: 1424–1425.
-
16.
Birbeck GL, French JA, Perucca E, Simpson DM, Fraimow H, George JM, Okulicz JF, Clifford DB, Hachad H, Levy RH; Quality Standards Subcommittee of the American Academy of Neurology; Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy, 2012. Evidence-based guideline: antiepileptic drug selection for people with HIV/AIDS: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy. Neurology 78: 139–145.
-
17.
Patel V, Simunyu E, Gwanzura F, Lewis G, Mann A, 1997. The Shona Symptom Questionnaire: the development of an indigenous measure of common mental disorders in Harare. Acta Psychiatr Scand 95: 469–475.
-
18.
Jelsma J, Mhundwa K, De Weerdt W, De Cock P, Chimera J, Chivaura V, 2001. The reliability of the Shona version of the EQ-5D. Cent Afr J Med 47: 8–13.
-
19.
Nakasujja N, Skolasky RL, Musisi S, Allebeck P, Robertson K, Ronald A, Katabira E, Clifford DB, Sacktor N, 2010. Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda. BMC Psychiatry 10: 44.
-
20.
van den Heuvel L, Chishinga N, Kinyanda E, Weiss H, Patel V, Ayles H, Harvey J, Cloete KJ, Seedat S, 2013. Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians. AIDS Care 25: 1527–1535.
-
21.
Hestad KA, Menon JA, Silalukey-Ngoma M, Franklin DR Jr, Imasiku ML, Kalima K, Heaton RK, 2012. Sex differences in neuropsychological performance as an effect of human immunodeficiency virus infection: a pilot study in Zambia, Africa. J Nerv Ment Dis 200: 336–342.
-
22.
Esplen E, 2007. Women and Girls Living with HIV/AIDS: Overview and Annotated Bibliography. Brighton, UK: Institute of Development Studies at the University of Sussex.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 915 | 804 | 41 |
| Full Text Views | 306 | 13 | 1 |
| PDF Downloads | 81 | 14 | 2 |
Cognitive Impairment and Psychiatric Morbidity in HIV+ Zambians with New-Onset Seizure
Lisa Kalungwana
Lisa Kalungwana
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Melissa A. Elafros
Melissa A. Elafros
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Omar K. Siddiqi
Omar K. Siddiqi
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Christopher M. Bositis
Christopher M. Bositis
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Izukanji Sikazwe
Izukanji Sikazwe
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Igor J. Koralnik
Igor J. Koralnik
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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William H. Theodore
William H. Theodore
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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Gretchen L. Birbeck
Gretchen L. Birbeck
Department of Psychology, University of Zambia, Lusaka, Zambia; International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; College of Human Medicine, Michigan State University, East Lansing, Michigan; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Division of NeuroVirology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Greater Lawrence Family Health Center, Lawrence, Massachusetts; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; Department of Neurology, Epilepsy Division, University of Rochester, Rochester, New York; Chikankata Epilepsy Care Team, Mazabuka, Zambia
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A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.
Author Notes
Financial support: This project was supported by Fogarty International Center and National Institute of Neurological Disorders and Stroke (NINDS) Grant 1R21NS073509. M.A.E. was supported, in part, by an MD/PhD Fellowship from Spectrum Health, the American Medical Association Foundation, and the Lois C. Walker Endowed Fund for Student Research at the Michigan State University College of Human Medicine. O.K.S. was supported an American Academy of Neurology Clinical Research Fellowship. I.J.K. is supported, in part, by NINDS Grants R01047029 and R01074995. W.H.T. was supported by the International League Against Epilepsy.
Authors' addresses: Lisa Kalungwana, Department of Psychology, University of Zambia, Lusaka, Zambia, E-mail: kalungwana.lisa@gmail.com. Melissa A. Elafros, International Neurologic and Psychiatric Epidemiology Program, East Lansing, MI, E-mail: elafrosm@msu.edu. Omar K. Siddiqi, Cumberland, RI, E-mail: osiddiqi@bidmc.harvard.edu. Christopher M. Bositis, Greater Lawrence Family Health Center, Lawrence, MA, E-mail: cbositis@glfhc.org. Izukanji Sikazwe, Center for Infectious Disease Research in Zambia, Lusaka, Zambia, E-mail: Izukanji.sikazwe@cidrz.org. Igor J. Koralnik, Beth Israel Deaconess Medical Center, Boston, MA, E-mail: ikoralni@bidmc.harvard.edu. William H. Theodore, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, E-mail: theodorw@ninds.nih.gov. Gretchen L. Birbeck, University of Rochester, Department of Neurology, Strong Epilepsy Center, Rochester, NY, E-mail: gretchen_birbeck@urmc.rochester.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Woods SP, Moore DJ, Weber E, Grant I, 2009. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19: 152–168.
-
2.
Beard J, Feeley F, Rosen S, 2009. Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review. AIDS Care 21: 1343–1356.
-
3.
Joska JA, Gouse H, Paul RH, Stein DJ, Flisher AJ, 2010. Does highly active antiretroviral therapy improve neurocognitive function? A systematic review. J Neurovirol 16: 101–114.
-
4.
Holguin A, Banda M, Willen EJ, Malama C, Chiyenu KO, Mudenda VC, Wood C, 2011. HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behav 15: 1895–1901.
-
5.
Sacktor N, Nakasujja N, Okonkwo O, Skolasky RL, Robertson K, Musisi S, Katabira E, 2013. Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda. J Neurovirol 19: 48–56.
-
6.
Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, McArthur JC, Ronald A, Sacktor N, 2007. Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68: 350–355.
-
7.
Kvalsund MP, Haworth A, Murman DL, Velie E, Birbeck GL, 2009. Closing gaps in antiretroviral therapy access: human immunodeficiency virus-associated dementia screening instruments for non-physician healthcare workers. Am J Trop Med Hyg 80: 1054–1059.
-
8.
Birbeck GL, Kvalsund MP, Byers PA, Bradbury R, Mang'ombe C, Organek N, Kaile T, Sinyama AM, Sinyangwe SS, Malama K, Malama C, 2011. Neuropsychiatric and socioeconomic status impact antiretroviral adherence and mortality in rural Zambia. Am J Trop Med Hyg 85: 782–789.
-
9.
Habib AG, Yakasai AM, Owolabi LF, Ibrahim A, Habib ZG, Gudaji M, Karaye KM, Ibrahim DA, Nashabaru I, 2013. Neurocognitive impairment in HIV-1-infected adults in sub-Saharan Africa: a systematic review and meta-analysis. Int J Infect Dis 17: e820–e831.
-
10.
Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N, 2004. Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort. Neurology 63: 822–827.
-
11.
Fischer-Smith T, Croul S, Sverstiuk AE, Capini C, L'Heureux D, Regulier EG, Richardson MW, Amini S, Morgello S, Khalili K, Rappaport J, 2001. CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection. J Neurovirol 7: 528–541.
-
12.
Cettomai D, Kwasa J, Birbeck GL, Price RW, Bukusi EA, Meyer AC, 2011. Training needs and evaluation of a neuro-HIV training module for non-physician healthcare workers in western Kenya. J Neurol Sci 307: 92–96.
-
13.
Kellinghaus C, Engbring C, Kovac S, Moddel G, Boesebeck F, Fischera M, Anneken K, Klonne K, Reichelt D, Evers S, Husstedt IW, 2008. Frequency of seizures and epilepsy in neurological HIV-infected patients. Seizure 17: 27–33.
-
14.
Garg RK, 1999. HIV infection and seizures. Postgrad Med J 75: 387–390.
-
15.
Birbeck G, Chomba E, Ddumba E, Kauye F, Mielke J, 2007. Lack of appropriate treatment for people with comorbid HIV/AIDS and epilepsy in sub-Saharan Africa. Epilepsia 48: 1424–1425.
-
16.
Birbeck GL, French JA, Perucca E, Simpson DM, Fraimow H, George JM, Okulicz JF, Clifford DB, Hachad H, Levy RH; Quality Standards Subcommittee of the American Academy of Neurology; Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy, 2012. Evidence-based guideline: antiepileptic drug selection for people with HIV/AIDS: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Ad Hoc Task Force of the Commission on Therapeutic Strategies of the International League Against Epilepsy. Neurology 78: 139–145.
-
17.
Patel V, Simunyu E, Gwanzura F, Lewis G, Mann A, 1997. The Shona Symptom Questionnaire: the development of an indigenous measure of common mental disorders in Harare. Acta Psychiatr Scand 95: 469–475.
-
18.
Jelsma J, Mhundwa K, De Weerdt W, De Cock P, Chimera J, Chivaura V, 2001. The reliability of the Shona version of the EQ-5D. Cent Afr J Med 47: 8–13.
-
19.
Nakasujja N, Skolasky RL, Musisi S, Allebeck P, Robertson K, Ronald A, Katabira E, Clifford DB, Sacktor N, 2010. Depression symptoms and cognitive function among individuals with advanced HIV infection initiating HAART in Uganda. BMC Psychiatry 10: 44.
-
20.
van den Heuvel L, Chishinga N, Kinyanda E, Weiss H, Patel V, Ayles H, Harvey J, Cloete KJ, Seedat S, 2013. Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians. AIDS Care 25: 1527–1535.
-
21.
Hestad KA, Menon JA, Silalukey-Ngoma M, Franklin DR Jr, Imasiku ML, Kalima K, Heaton RK, 2012. Sex differences in neuropsychological performance as an effect of human immunodeficiency virus infection: a pilot study in Zambia, Africa. J Nerv Ment Dis 200: 336–342.
-
22.
Esplen E, 2007. Women and Girls Living with HIV/AIDS: Overview and Annotated Bibliography. Brighton, UK: Institute of Development Studies at the University of Sussex.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 915 | 804 | 41 |
| Full Text Views | 306 | 13 | 1 |
| PDF Downloads | 81 | 14 | 2 |