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Elevation of Serum B-Cell Activating Factor Levels During Visceral Leishmaniasis

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  • Laboratory of Molecular Immunology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

Elevation of serum B-cell activating factor (BAFF) is one of the characteristics of immunological disorders, including autoimmunity, but the levels of BAFF in infectious diseases have not been studied well. Here, we showed the elevation of serum BAFF in patients with visceral leishmaniasis (VL). The mean serum BAFF value in VL patients (4.65 ng/mL) was 4.3 times higher than that of healthy controls (1.08 ng/mL), and 90% of VL patients showed serum BAFF above the cutoff that was calculated as the mean + 3 SDs of the controls. This report is the first on elevation of serum BAFF during VL.

Author Notes

* Address correspondence to Yasuyuki Goto, Laboratory of Molecular Immunology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. E-mail: aygoto@mail.ecc.u-tokyo.ac.jp† These authors contributed equally.

Financial support: This study was supported by KAKENHI Grants 23689024 and 23256001 from the Japan Society for the Promotion of Science and a grant from the Japan Science and Technology Agency/the Japan International Cooperation Agency, SATREPS.

Authors' addresses: Yasuyuki Goto, Satoko Omachi, Chizu Sanjoba, and Yoshitsugu Matsumoto, Laboratory of Molecular Immunology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, E-mails: aygoto@mail.ecc.u-tokyo.ac.jp, satoko.bbk@gmail.com, asanjoba@mail.ecc.u-tokyo.ac.jp, and aysmatsu@mail.ecc.u-tokyo.ac.jp.

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