Preliminary Study on Tubuloglomerular Dysfunction and Evidence of Renal Inflammation in Patients with Visceral Leishmaniasis

Michelle J. C. Oliveira Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Geraldo B. Silva Junior Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Aline M. Sampaio Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Bárbara L. Montenegro Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Marília P. Alves Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Guilherme A. L. Henn Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Hermano A. L. Rocha Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Gdayllon C. Meneses Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Alice M. C. Martins Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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Elizabeth F. Daher Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.14-0167
Volume/Issue:
Volume 91: Issue 5
Page(s):
908–911
Restricted access
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Visceral leishmaniasis (VL) is a re-emerging zoonosis of worldwide distribution. Monocyte chemotactic protein-1 (MCP-1) and malondialdehyde (MDA) are inflammation biomarkers that have never been investigated in VL. The aim of this study is to investigate the association between renal abnormalities and inflammation biomarkers in VL. This study is a preliminary prospective study with 16 VL adult patients evaluated before treatment compared with a group of 13 healthy volunteers and 5 VL patients evaluated after treatment. Urinary concentration and acidification tests were performed. MCP-1 and MDA were quantified in urine. Urinary concentration deficit was found in all VL patients before (100%) and four VL patients after (80%) treatment. Urinary acidification deficit was found in nine cases before (56.2%) and two cases after (40%) treatment. Urinary MCP-1 (374 ± 359 versus 42 ± 29 pg/mg creatinine, P = 0.002) as well as urinary MDA (5.4 ± 2.6 versus 2.0 ± 0.8 μmol/mL) showed significant differences between VL patients and controls. These data show that VL patients present urinary concentration and acidification deficit, which can persist even after specific treatment. Urinary MCP-1 and MDA are elevated in patients with VL, which suggests renal inflammation and incipient renal damage.

Author Notes

* Address correspondence to Elizabeth F. Daher, Department of Internal Medicine, Federal University of Ceará, Rua Vicente Linhares, 1198, CEP: 60135-270, Fortaleza, Ceará, Brazil. E-mail: ef.daher@uol.com.br

Financial support: This research was supported by the Brazilian Research Council (CNPq).

Authors' addresses: Michelle J. C. Oliveira, Aline M. Sampaio, Bárbara L. Montenegro, Marília P. Alves, and Elizabeth F. Daher, Department of Internal Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil, E-mails: mi_cavalcante@hotmail.com, aline_sampa@hotmail.com, barbararlmontenegro@hotmail.com, lilah_alves@hotmail.com, and ef.daher@uol.com.br. Geraldo B. Silva Junior, School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil, E-mail: geraldobezerrajr@yahoo.com.br. Guilherme A. L. Henn and Hermano A. L. Rocha, Department of Community Health, Federal University of Ceara, Fortaleza, Ceara, Brazil, E-mails: guialhenn@gmail.com and hermanoalexandre@gmail.com. Gdayllon C. Meneses and Alice M. C. Martins, School of Pharmacy, Federal University of Ceara, Fortaleza, Ceara, Brazil, E-mail: gdayllon@yahoo.com.br and martinsalice@gmail.com.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2014
Received:
19 Mar 2014
|
Accepted:
03 Jul 2014
|
Published Online:
05 Nov 2014
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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