• 1.

    Kennedy CC, Limper AH, 2007. Redefining the clinical spectrum of chronic pulmonary histoplasmosis: a retrospective case series of 46 patients. Medicine (Baltimore) 86: 252258.

    • Search Google Scholar
    • Export Citation
  • 2.

    Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA, 2011. An official American Thoracic Society statement: treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med 183: 96128.

    • Search Google Scholar
    • Export Citation
  • 3.

    Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, Viard JP, Dromer F, Lortholary O, 2007. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis 13: 16471652.

    • Search Google Scholar
    • Export Citation
  • 4.

    Manfredi R, Mazzoni A, Nanetti A, Chiodo F, 1994. Histoplasmosis capsulati and duboisii in Europe: the impact of the HIV pandemic, travel and immigration. Eur J Epidemiol 10: 675681.

    • Search Google Scholar
    • Export Citation
  • 5.

    Pellaton C, Cavassini M, Jaton-Ogay K, Carron PN, Christen-Zaech S, Calandra T, Bille J, Hauser PM, 2009. Histoplasma capsulatum var. duboisii infection in a patient with AIDS: rapid diagnosis using polymerase chain reaction-sequencing. Diagn Microbiol Infect Dis 64: 8589.

    • Search Google Scholar
    • Export Citation
  • 6.

    Pieron R, Mafart Y, Barranger C, Houdard C, Boury G, Favre M, Lancastre F, Le Fichoux Y, 1973. Cold thoracic abscess due to Histoplasma duboisii. Treatment using rifampicin [in French]. Sem Hop 49: 30093014.

    • Search Google Scholar
    • Export Citation
  • 7.

    Sanguino JC, Rodrigues B, Baptista A, Quina M, 1996. Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. Hepatogastroenterology 43: 771775.

    • Search Google Scholar
    • Export Citation
  • 8.

    Tsiodras S, Drogari-Apiranthitou M, Pilichos K, Leventakos K, Kelesidis T, Buitrago MJ, Petrikkos G, Panayiotides I, 2012. An unusual cutaneous tumor: African histoplasmosis following mudbaths: case report and review. Am J Trop Med Hyg 86: 261263.

    • Search Google Scholar
    • Export Citation
  • 9.

    Gugnani HC, 2000. Histoplasmosis in Africa: a review. Indian J Chest Dis Allied Sci 42: 271277.

  • 10.

    Williams AO, Lawson EA, Lucas AO, 1971. African histoplasmosis due to Histoplasma duboisii. Arch Pathol 92: 306318.

  • 11.

    Dupont B, 1996. Imported histoplasmosis due to H. duboisii in France (1968–1994). 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana.

    • Search Google Scholar
    • Export Citation
  • 12.

    Dupont B, Drouhet E, Lapresle C, 1974. Systemic histoplasmosis with Histoplasma duboisii. Miliary pulmonary form with fatal termination [in French]. Nouv Presse Med 3: 10051007.

    • Search Google Scholar
    • Export Citation
  • 13.

    Mandell GL, Bennett JE, Dolin R, 2009. Histoplasmosis. Principles and Practice of Infectious Diseases. Oxford, United Kingdom; 33053318.

  • 14.

    Couppie P, Sobesky M, Aznar C, Bichat S, Clyti E, Bissuel F, El Guedj M, Alvarez F, Demar M, Louvel D, Pradinaud R, Carme B, 2004. Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors. Clin Infect Dis 38: 134138.

    • Search Google Scholar
    • Export Citation
  • 15.

    Nacher M, Adenis A, Adriouch L, Dufour J, Papot E, Hanf M, Vantilcke V, Calvez M, Aznar C, Carme B, Couppie P, 2011. What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis. Am J Trop Med Hyg 84: 239240.

    • Search Google Scholar
    • Export Citation
  • 16.

    Peigne V, Dromer F, Elie C, Lidove O, Lortholary O, the French Mycosis Study Group, 2011. Imported acquired immunodeficiency syndrome–related histoplasmosis in metropolitan France: a comparison of pre–highly active anti-retroviral therapy and highly active anti-retroviral therapy eras. Am J Trop Med Hyg 85: 934941.

    • Search Google Scholar
    • Export Citation
  • 17.

    Dallot A, Monsuez JJ, Chanu B, Vittecocq D, Verola O, Badillet G, Rouffy J, Morel P, Puissant A, 1988. Cutaneous localizations of disseminated Histoplasma capsulatum histoplasmosis in a case of acquired immunodeficiency [in French]. Ann Dermatol Venereol 115: 441447.

    • Search Google Scholar
    • Export Citation
  • 18.

    Ashbee HR, Evans EG, Viviani MA, Dupont B, Chryssanthou E, Surmont I, Tomsikova A, Vachkov P, Enero B, Zala J, Tintelnot K, 2008. Histoplasmosis in Europe: report on an epidemiological survey from the European Confederation of Medical Mycology Working Group. Med Mycol 46: 5765.

    • Search Google Scholar
    • Export Citation
  • 19.

    Torres-Rodriguez JM, Segura-Roca G, Coll J, 2009. Histoplasmosis 45 years after infection in an immunocompetent man [in Spanish]. Rev Iberoam Micol 26: 244246.

    • Search Google Scholar
    • Export Citation
  • 20.

    Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 45: 807825.

    • Search Google Scholar
    • Export Citation
  • 21.

    Hot A, Maunoury C, Poiree S, Lanternier F, Viard JP, Loulergue P, Coignard H, Bougnoux ME, Suarez F, Rubio MT, Mahlaoui N, Dupont B, Lecuit M, Faraggi M, Lortholary O, 2010. Diagnostic contribution of positron emission tomography with [18F]fluorodeoxyglucose for invasive fungal infections. Clin Microbiol Infect 17: 409417.

    • Search Google Scholar
    • Export Citation
  • 22.

    Lortholary O, Charlier C, Lebeaux D, Lecuit M, Consigny PH, 2013. Fungal infections in immunocompromised travelers. Clin Infect Dis 56: 861869.

  • 23.

    Richaud C, Lebeaux D, Lortholary O, 2013. Fungal infections associated with travel. Curr Fungal Infect Rep 7: 311319.

 
 
 
 

 

 
 

 

 

 

 

 

 

Imported African Histoplasmosis in an Immunocompetent Patient 40 Years after Staying in a Disease-Endemic Area

View More View Less
  • Université Paris Descartes, Sorbonne Paris Cité, France; Service des Maladies Infectieuses et Tropicales et Centre d'Infectiologie Necker Pasteur, Service d'Hématologie Adultes, Centre d'Etude des Déficits Immunitaires, et Service de Microbiologie, Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Paris, France; Service de Pneumologie, Hôpital Simone Veil, Eaubonne, France; Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Centre National de la Recherche Scientifique, Unité Recherche Associée 3012, Paris, France; Laboratoire de Génétique Humaine des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale Unité 980, Faculté Necker, Fondation IMAGINE, Université Paris Descartes, Paris, France

Histoplasmosis caused by Histoplasma capsulatum var. duboisii is a rare disease outside central and western Africa. In Europe, all cases are imported. We report a case of an African histoplasmosis with isolated pulmonary involvement in a non-immunocompromised patient that occurred 40 years after his stay in a disease-endemic area. The patient was given itraconazole. 18F-fluoro-2-deoxy-d-glucose positron emission tomography–computed tomography was used to assess evolution during treatment. The outcome for the patient was favorable.

Author Notes

* Address correspondence to Clémence Richaud, Service des Maladies Infectieuses et Tropicales, hôpital Necker, 149 rue de Sèvres, 75015, Paris, France. E-mail: clemence.richaud@gmail.com

Authors' addresses: Clémence Richaud, Service des Maladies Infectieuses et Tropicales, hôpital Necker, 149 rue de Sèvres, 75015, Paris, France, E-mail: clemence.richaud@gmail.com. Marie-Olivia Chandesris, Service d'Hématologie Adultes, Université Paris Descartes, Sorbonne Paris Cité Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Paris, France, E-mail: olivia.chandesris@nck.aphp.fr. Fanny Lanternier, Service d'Hématologie Adultes, Université Paris Descartes, Sorbonne Paris Cité Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Paris, France, and Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Centre National de la Recherche Scientifique, Unité Recherche Associée 3012, Paris, France, E-mail: fanny.lanternier@nck.aphp.fr. Hélène Benzaquen-Forner, Service de Pneumologie, Hôpital Simone Veil, Eaubonne, France, E-mail: helene.benzaquen@ch-simoneveil.fr. Dea Garcia-Hermoso, Istitut Pasteur, Unité de Mycologie Moléculaire Centre National de Référence Mycoses Invasives et Antifongiques, Centre National de la Recherche Scientifique Unité Recherche Associée 3012, Paris, France, E-mail: dea.garcia-hermoso@pasteur.fr. Capucine Picard, Centre d’Etude des Déficits Immunitaires, Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Paris, France, and Laboratoire de Génétique Humaine des Maladies Infectieuses, Université Paris Descartes, Sorbonne Paris Cité, Faculté Necker, Fondation IMAGINE, Institut National de la Santé et de la Recherche Médicale Unité 980, Paris, France, E-mail: capucine.picard@nck.aphp.fr. Emilie Catherinot, Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Service des Maladies Infectieuses et Tropicales et Centre d'Infectiologie Necker Pasteur, Paris, France, E-mail: e.catherinot@gmail.com. Marie-Elisabeth Bougnoux, Université Paris Descartes, Sorbonne Paris Cité Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Service de Microbiologie, Paris, France, E-mail: mbougnoux6@gmail.com. Olivier Lortholary, Institut Pasteur, Unité de Mycologie Moléculaire Centre National de Référence Mycoses Invasives et Antifongiques, Centre National de la Recherche Scientifique Unité Recherche Associée 3012, Paris, France, and Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants-Malades, Assistance Publique–Hôpitaux de Paris, Service des Maladies Infectieuses et Tropicales et Centre d'Infectiologie Necker Pasteur, Paris, France, E-mail: olivier.lortholary@nck.aphp.fr.

Save