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Asymptomatic Intestinal Amebiasis in Japanese HIV-1–Infected Individuals

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  • AIDS Clinical Center, Department of Gastroenterology and Hepatology, and Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan; Center for AIDS Research, Kumamoto University, Kumamoto, Japan

Seventy-one asymptomatic human immunodeficiency virus-1 (HIV-1) -infected individuals who underwent colonoscopy for detection of diseases other than amebiasis were included in this study. Ulcerative lesions caused by Entamoeba histolytica were identified by colonoscopy and biopsy in 11.3% (8 of 71) of individuals. Stool microscopic examination hardly identified Entamoeba, whereas serum antibody against E. histolytica was often elevated in patients with subclinical intestinal amebiasis. Human leukocyte antigen (HLA) class II allele against E. histolytica infection (DQB1*06:01) was frequently identified in these patients. This study emphasizes the endemic nature of E. histolytica infection in our cohort and the difficulties in epidemiological control.

Author Notes

* Address correspondence to Hiroyuki Gatanaga, AIDS Clinical Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. E-mail: higatana@acc.ncgm.go.jp

Financial support: This study was supported by a grant for from the Ministry of Health, Labor, and Welfare of Japan (H25-promotion-general-014).

Authors' addresses: Koji Watanabe, Junko Tanuma, Yoshimi Kikuchi, Shinichi Oka, and Hiroyuki Gatanaga, AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan, E-mails: kwatanab@acc.ncgm.go.jp, jtanuma@acc.ncgm.go.jp, yoshik@acc.ncgm.go.jp, oka@acc.ncgm.go.jp, and higatana@acc.ncgm.go.jp. Naoyoshi Nagata, Katsunori Sekine, and Kazuhiro Watanabe, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan, E-mails: nnagata_ncgm@yahoo.co.jp, hawaiiantuberider@gmail.com, and 12pagani@yahoo.co.jp. Toru Igari, Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, National Center for Global Health and Medicine, Tokyo, Japan, E-mail: tigari@hosp.ncgm.go.jp.

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