Endomyocardial Fibrosis (EMF) in a Ugandan Child with Advanced Hepatosplenic Schistosomiasis: Coincidence or Connection?

Amaya L. Bustinduy Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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Kenneth Luzinda Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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Simon Mpoya Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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Philip Gothard Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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Neil Stone Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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Stephen Wright Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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J. Russell Stothard Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Pediatrics, Guy's and St. Thomas's National Health Service (NHS) Trust, London, United Kingdom; Department of Internal Medicine, Mulago Hospital, Kampala, Uganda; Department of Radiology, Mulago Hospital, Kampala, Uganda; Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom; Department of Infection, Guy's and St. Thomas's NHS Trust, London, United Kingdom

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An association between late-stage hepatosplenic schistosomiasis and endomyocardial fibrosis (EMF) has been suggested but not proven. We present the case of a 12-year-old Ugandan boy with striking comorbidities, including advanced periportal fibrosis caused by Schistosoma mansoni infection and right ventricular EMF, and discuss the possible correlation between both diseases.

Author Notes

* Address correspondence to Amaya L. Bustinduy, Parasitology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom. E-mail: Amaya.Bustinduy@liverpool.ac.uk

Financial support: The study team received financial support from the London School of Hygiene and Tropical Medicine through the East African Diploma in Tropical Medicine and Hygiene.

Authors' addresses: Amaya L. Bustinduy, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, and Department of Pediatrics, Guy's and St. Thomas's NHS Trust, London, United Kingdom, E-mail: Amaya.Bustinduy@liverpool.ac.uk. Kenneth Luzinda, Department of Internal Medicine, Mulago Hospital, Kampala, Uganda, E-mail: luzindaken@gmail.com. Simon Mpoya, Department of Radiology, Mulago Hospital, Kampala, Uganda, E-mail: mposim2001@yahoo.co.uk. Philip Gothard and Stephen Wright, Hospital for Tropical Diseases, Mortimer Market Centre, London, United Kingdom, E-mails: philip.gothard@uclh.nhs.uk and stephenwright1@doctors.org.uk. Neil Stone, Department of Infection, Guy's and St. Thomas's NHS Trust, London, London, United Kingdom, E-mail: Neil.Stone@gstt.nhs.uk. J. Russell Stothard, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, E-mail: R.Stothard@liverpool.ac.uk.

  • 1.

    Gryseels B, Polman K, Clerinx J, Kestens L, 2006. Human schistosomiasis. Lancet 368: 11061118.

  • 2.

    Rashwan MA, Ayman M, Ashour S, Hassanin MM, Zeina AA, 1995. Endomyocardial fibrosis in Egypt: an illustrated review. Br Heart J 73: 284289.

  • 3.

    Bukhman G, Ziegler J, Parry E, 2008. Endomyocardial fibrosis: still a mystery after 60 years. PLoS Negl Trop Dis 2: e97.

  • 4.

    Vijayaraghavan G, Sivasankaran S, 2012. Tropical endomyocardial fibrosis in India: a vanishing disease! Indian J Med Res 136: 729738.

  • 5.

    Mocumbi AO, Falase AO, 2014. Republished: recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. Postgrad Med J 90: 4854.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Rutakingirwa M, Ziegler JL, Newton R, Freers J, 1999. Poverty and eosinophilia are risk factors for endomyocardial fibrosis (EMF) in Uganda. Trop Med Int Health 4: 229235.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Andy JJ, Ogunowo PO, Akpan NA, Odigwe CO, Ekanem IA, Esin RA, 1998. Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. Acta Trop 69: 127140.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Carneiro R de C, Santos AL, Brant LC, Rabelo FT, Ligeiro CM, Barcelos IP, Silva VB, Silva VS, Nunes M do C, 2011. Endomyocardial fibrosis associated with mansoni schistosomiasis. Rev Soc Bras Med Trop 44: 644645.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Sousa-Figueiredo JC, Pleasant J, Day M, Betson M, Rollinson D, Montresor A, Kazibwe F, Kabatereine NB, Stothard JR, 2010. Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole. In Health 2: 103113.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Richter J, Hatz C, Campagne G, Bergquist NR, Jenkins JM; UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, 2000. Ultrasound in schistosomiasis: a practical guide to the standard use of ultrasonography for assessment of schistosomiasis-related morbidity. Proceedings of the Second International Workshop, October 22–26, 1996; Niamey, Niger.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Mocumbi AO, Ferreira MB, Sidi D, Yacoub MH, 2008. A population study of endomyocardial fibrosis in a rural area of Mozambique. N Engl J Med 359: 4349.

  • 12.

    Connor DH, Somers K, Hutt MS, Manion WC, D'Arbela PG, 1967. Endomyocardial fibrosis in Uganda (Davies' disease). 1. An epidemiologic, clinical, and pathologic study. Am Heart J 74: 687709.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Barbosa MM, Lamounier JA, Oliveira EC, Souza MV, Marques DS, Lambertucci JR, 1998. Short report: endomyocardial fibrosis and cardiomyopathy in an area endemic for schistosomiasis. Am J Trop Med Hyg 58: 2627.

    • PubMed
    • Search Google Scholar
    • Export Citation
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