Risk Factors for Opisthorchis viverrini and Minute Intestinal Fluke Infections in Lao PDR, 2009–2011

Hee Jung Yoon Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Hee Jung Yoon in
Current site
Google Scholar
PubMed Close
,
Moran Ki Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Moran Ki in
Current site
Google Scholar
PubMed Close
,
Keeseon Eom Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Keeseon Eom in
Current site
Google Scholar
PubMed Close
,
Tai-Soon Yong Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Tai-Soon Yong in
Current site
Google Scholar
PubMed Close
,
Jong-Yil Chai Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Jong-Yil Chai in
Current site
Google Scholar
PubMed Close
,
Duk-Young Min Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Duk-Young Min in
Current site
Google Scholar
PubMed Close
,
Han-Jong Rim Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Han-Jong Rim in
Current site
Google Scholar
PubMed Close
,
Woon-Mok Sohn Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Woon-Mok Sohn in
Current site
Google Scholar
PubMed Close
,
Bounnaloth Insisiengmay Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Bounnaloth Insisiengmay in
Current site
Google Scholar
PubMed Close
, and
Bounlay Phommasack Department of Infectious Diseases, College of Medicine, Eulji University, Daejeon, Korea; Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea; Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea; Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Microbiology, College of Medicine, Eulji University, Daejeon, Korea; Department of Parasitology, Korea University School of Medicine, Seoul, Korea; Department of Parasitology and Institute of Health Sciences, Gyeongsang National University, School of Medicine, Jinju, Korea; Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR

Search for other papers by Bounlay Phommasack in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.13-0596
Volume/Issue:
Volume 91: Issue 2
Page(s):
384–388
Restricted access
Get Permissions

The purpose of this report is to compare the prevalence of Opisthorchis viverrini/minute intestinal fluke (Ov/MIF) in Lao People's Democratic Republic according to different regions and evaluate the effect of ingestion of raw freshwater fish on the infection. Demographic data, behavioral data, and symptoms were obtained, and the Kato–Katz method was used for the diagnosis of Ov/MIF. In total, 3,046 individuals were enrolled. The risk factors associated with acquisition of Ov/MIF were raw fish consumption and province. Khong Island showed the highest prevalence (odds ratio = 80.1, 95% confidence interval = 47.9–133.9, P < 0.001) compared with other districts, and raw fish consumption was related to Ov/MIF infection. Administration of praziquantel to entire populations, education (avoiding consumption of raw food dishes and improved hygiene), and access to clean water and sanitation should be considered.

Author Notes

* Address correspondence to Moran Ki, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Korea. E-mail: moranki@naver.com

Authors' addresses: Hee Jung Yoon, Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea, E-mail: yhj822@medimail.co.kr. Moran Ki, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea, E-mail: moranki@naver.com. Keeseon Eom, Department of Parasitology and Medical Research Institute, School of Medicine, Chungbuk National University, Cheongju, Korea, E-mail: keeseon.eom@gmail.com. Tai-Soon Yong, Department of Environmental Medical Biology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea, E-mail: tsyong212@gmail.com. Jong-Yil Chai, Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea, E-mail: cjy@snu.ac.kr. Duk-Young Min, Department of Microbiology, Eulji University, Daejeon, Korea, E-mail: dymin@eulji.ac.kr. Han-Jong Rim, Department of Parasitology, Korea University, Seoul, Korea, E-mail: hjrim@korea.ac.kr. Woon-Mok Sohn, Department of Parasitology, Gyeongsang University, Jinju, Korea, E-mail: wmsohn@gnu.ac.kr. Bounnaloth Insisiengmay and Bounlay Phommasack, Department of Communicable Disease Control, Ministry of Health, Vientiane, Lao PDR.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2014
Received:
15 Oct 2013
|
Accepted:
24 Mar 2014
|
Published Online:
06 Aug 2014
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
  • 1.

    Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B, 2012. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int 61: 10–16.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Forrer A, Sayasone S, Vounatsou P, Vonghachack Y, Bouakhasith D, Vogt S, Glaser R, Utzinger J, Akkhavong K, Odermatt P, 2012. Spatial distribution of, and risk factors for, Opisthorchis viverrini infection in southern Lao PDR PDR. PLoS Negl Trop Dis 6: e1481.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Lao PDR Statistics Bureau, 2005. Census 2005. Available at: http://www.nsc.gov.la. Accessed June 24, 2014

  • 4.

    Sripa B, Bethony JM, Sithithaworn P, Kaewkes S, Mairiang E, Loukas A, Mulvenna J, Laha T, Hotez PJ, Brindley PJ, 2011. Opisthorchiasis and Opisthorchis-associated CCA in Thailand and Lao PDR. Acta Trop 120: S158–S168.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Rim HJ, Sohn WM, Yong TS, Eom KS, Chai JY, Min DY, Lee SH, Hoang EH, Phommasack B, Insisiengmay S, 2013. Fishborne trematode metacercariae in Luang Prabang, Khammouane, and Saravanee Province, Lao PDR PDR. Korean J Parasitol 51: 107–114.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Sayasone S, Vonghajack Y, Vanmany M, Rasphone O, Tesana S, Utzinger J, Akkhavong K, Odermatt P, 2009. Diversity of human intestinal helminthiasis in Lao PDR. Trans R Soc Trop Med Hyg 103: 247–254.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ, 2007. Liver fluke induces CCA. PLoS Med 4: e201.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    IARC, 1994. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7–14 June 1994. IARC Monogr Eval Carcinog Risks Hum 61: 121.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    IARC, 1994. Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis). IARC Monogr Eval Carcinog Risks Hum 61: 121–175.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Andrews RH, Sithithaworn P, Petney TN, 2008. Opisthorchis viverrini: an underestimated parasite in world health. Trends Parasitol 24: 497–501.

  • 11.

    Gatto M, Bragazzi MC, Semeraro R, Napoli C, Gentile R, Torrice A, Gaudio E, Alvaro D, 2010. Cholangiocarcinoma: update and future perspectives. Dig Liver Dis 42: 253–260.

  • 12.

    Morris-Stiff G, Bhati C, Olliff S, Hübscher S, Gunson B, Mayer D, Mirza D, Buckels J, Bramhall SR, 2008. Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience. Dig Surg 25: 126–132.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Patel AH, Harnois DM, Klee GG, LaRusso NF, Gores GJ, 2000. The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis. Am J Gastroenterol 95: 204–207.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Lempinen M, Isoniemi H, Mäkisalo H, Nordin A, Halme L, Arola J, Höckerstedt K, Stenman UH, 2007. Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol 47: 677–683.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Chapman MH, Sandanayake NS, Andreola F, Dhar DK, Webster GJ, Dooley JS, Pereira SP, 2011. Circulating CYFRA 21-1 is a specific diagnostic and prognostic biomarker in biliary tract cancer. J Clin Exp Hepatol 1: 6–12.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Uenishi T, Yamazaki O, Tanaka H, Takemura S, Yamamoto T, Tanaka S, Nishiguchi S, Kubo S, 2008. Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma. Ann Surg Oncol 15: 583–589.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Spripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A, 2012. The tumorigenic liver fluke Opisthorchis viverrini–multiple pathways to cancer. Trends Parasitol 28: 395–407.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Sithithaworn P, Haswell-Elkins M, 2003. Epidemiology of Opisthorchis viverrini. Acta Trop 88: 187–194.

  • 19.

    Parkin DM, 2006. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030–3044.

  • 20.

    Herrera LA, Benítez-Bribiesca L, Mohar A, Ostrosky-Wegman P, 2005. Role of infectious diseases in human carcinogenesis. Environ Mol Mutagen 45: 284–303.

  • 21.

    Kuper H, Adami HO, Trichopoulos D, 2000. Infections as a major preventable cause of human cancer. J Intern Med 248: 171–183.

Past two years Past Year Past 30 Days
Abstract Views 77 77 45
Full Text Views 387 116 0
PDF Downloads 87 18 1
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save