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Congenital Transmission of Multidrug-Resistant Tuberculosis

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  • Department of Pediatrics, Hospital Nacional Dos de Mayo, Lima, Peru; Department of Pulmonology, Hospital Nacional Dos de Mayo, Lima, Peru; “Santa Martha” Health Centre, Ministerio de Salud (MINSA), Lima, Peru; Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom; Laboratory of the Universidad Peruana Cayetano Heredia, Lima, Peru; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB to the infant was suspected, because direct postpartum transmission was considered unlikely; also, thorough screening of contacts for TB was negative. Spoligotyping confirmed that both mother and baby were infected with identical strains of the Beijing family (SIT1).

Author Notes

* Address correspondence to Daniela E. Kirwan, Department of Infectious Diseases and Immunity, Imperial College London, Du Cane Road, London W7 0DT, United Kingdom. E-mail: dannikirwan@yahoo.com

Authors' addresses: Nora Espiritu and Lino Aguirre, Department of Pediatrics, Hospital Nacional Dos de Mayo, Lima, Peru, E-mails: nora1652@yahoo.es and linoped@hotmail.com. Oswaldo Jave, Department of Pulmonology, Hospital Nacional Dos de Mayo, Lima, Peru, E-mail: rigeljave2008@yahoo.es. Luis Sanchez, “Santa Martha” Health Centre, Ministerio de Salud (MINSA), Lima, Peru, E-mail: sanchez6868@gmail.com. Daniela E. Kirwan, Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom, E-mail: dannikirwan@yahoo.com. Robert H. Gilman, Laboratory of the Universidad Peruana Cayetano Heredia, Lima, Peru, and Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, E-mail: rgilman@jhsph.edu.

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