Reactivation of Mucosal and Cutaneous Leishmaniasis in a Renal Transplanted Patient

Felipe F. Tuon Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Giovana Marina Bombonatto Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Eveline Roesler Battaglin Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Marcus Henrique Sakumoto Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Valdir Sabbaga Amato Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Raphael Abegão de Camargo Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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Antônio Carlos Nicodemo Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil; Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil; Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil; Parasitology Laboratory Medical Research, Clinical Hospital, University of São Paulo, Medical School, São Paulo, Brazil

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DOI:
https://doi.org/10.4269/ajtmh.13-0578
Volume/Issue:
Volume 91: Issue 1
Page(s):
81–83
Restricted access
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Mucosal leishmaniasis (ML) is a chronic form of tegumentary leishmaniasis, which causes destructive lesions of nasal, pharyngeal, and laryngeal mucosa. We describe a case of leishmaniasis reactivation with simultaneous cutaneous and mucosal forms in a renal transplanted patient with no history of prior leishmaniasis. Reactivation after renal transplantation was not reported in Brazil. A 67-year-old woman receiving prednisone 20 mg/day, tacrolimus 1 mg/day, and mycophenolic acid 360 mg/day presented with nose edema with erythema and cutaneous lesions. Amastigotes were identified on biopsies and the polymerase chain reaction confirmed Leishmania (Viannia) braziliensis. The patient was treated with liposomal amphotericin B but died 3 weeks after as a result of bacterial septic shock. In conclusion, tegumentary leishmaniasis can reactivate with simultaneous cutaneous and mucosal forms in a renal transplanted patient during the immunosuppressant therapy.

Author Notes

* Address correspondence to Felipe Francisco Tuon, Infectious and Parasitic Diseases Clinic, Hospital Universitário Evangélico de Curitiba, Alameda Augusto Stellfeld 1908, 3°. andar – SCIH - Bigorrilho, CEP no. 80730-150, Curitiba, Brazil. E-mail: flptuon@gmail.com

Authors' addresses: Felipe Tuon, Universidade Federal do Parana, Division of Infectious Diseases, Curitiba, Parana, Brazil, E-mail: flptuon@gmail.com. Giovana Marina Bombonatto, Eveline Roesler Battaglin, and Marcus Henrique Sakumoto, Hospital Universitário Evangélico de Curitiba, Division of Infectious and Parasitic Diseases, Curitiba, Parana, Brazil, E-mails: gibombonatto@gmail.com, everoesler@uol.com.br, and marcushenrique@hotmail.com. Valdir Sabbaga Amato, University of Sao Paulo, Department of Infectious and Parasitic Diseases, School of Medicine Alameda Gabriel Monteiro da Silva, Sao Paulo, Brazil, E-mail: valdirsa@netpoint.com.br. Raphael Abegão de Camargo, Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil, E-mail: raphabegao@yahoo.com.br. Antônio Carlos Nicodemo, University of Sao Paulo, Department of Infectious Diseases, Sao Paulo, Brazil, E-mail: ac_nicodemo@uol.com.br.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2014
Received:
05 Oct 2013
|
Accepted:
16 Mar 2014
|
Published Online:
02 Jul 2014
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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