• 1.

    Kauffman CA, 2007. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 20: 115132.

  • 2.

    Ge L, Zhou C, Song Z, Zhang Y, Wang L, Zhong B, Hao F, 2010. Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient. Int J Infect Dis 14 (Suppl 3): e325e328.

    • Search Google Scholar
    • Export Citation
  • 3.

    Cao C, Bulmer G, Li J, Liang L, Lin Y, Xu Y, Luo Q, 2010. Indigenous case of disseminated histoplasmosis from the Penicillium marneffei endemic area of China. Mycopathologia 170: 4750.

    • Search Google Scholar
    • Export Citation
  • 4.

    Pan B, Chen M, Pan W, Liao W, 2013. Histoplasmosis: a new endemic fungal infection in China? Review and analysis of cases. Mycoses 56: 212221.

  • 5.

    Kasuga T, White TJ, Koenig G, McEwen J, Restrepo A, Castaneda E, Da Silva Lacaz C, Heins-Vaccari EM, De Freitas RS, Zancope-Oliveira RM, Qin Z, Negroni R, Carter DA, Mikami Y, Tamura M, Taylor ML, Miller GF, Poonwan N, Taylor JW, 2003. Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol Ecol 12: 33833401.

    • Search Google Scholar
    • Export Citation
  • 6.

    de Hoog GS, Vicente V, Caligiorne RB, Kantarcioglu S, Tintelnot K, Gerrits van den Ende AH, Haase G, 2003. Species diversity and polymorphism in the Exophiala spinifera clade containing opportunistic black yeast-like fungi. J Clin Microbiol 41: 47674778.

    • Search Google Scholar
    • Export Citation
  • 7.

    Tamura M, Kasuga T, Watanabe K, Katsu M, Mikami Y, Nishimura K, 2002. Phylogenetic characterization of Histoplasma capsulatum strains based on ITS region sequences, including two new strains from Thai and Chinese patients in Japan. Nihon Ishinkin Gakkai Zasshi 43: 1119.

    • Search Google Scholar
    • Export Citation
  • 8.

    Guedes HL, Guimaraes AJ, Muniz M de M, Pizzini CV, Hamilton AJ, Peralta JM, Deepe GS Jr, Zancope-Oliveira RM, 2003. PCR assay for identification of Histoplasma capsulatum based on the nucleotide sequence of the M antigen. J Clin Microbiol 41: 535539.

    • Search Google Scholar
    • Export Citation
  • 9.

    Frias De Leon MG, Arenas Lopez G, Taylor ML, Acosta Altamirano G, Reyes-Montes M del R, 2012. Development of specific sequence-characterized amplified region markers for detecting Histoplasma capsulatum in clinical and environmental samples. J Clin Microbiol 50: 673679.

    • Search Google Scholar
    • Export Citation
  • 10.

    Kasuga T, Taylor JW, White TJ, 1999. Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling. J Clin Microbiol 37: 653663.

    • Search Google Scholar
    • Export Citation
  • 11.

    Martinez LR, Mihu MR, Gacser A, Santambrogio L, Nosanchuk JD, 2009. Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis 200: 131141.

    • Search Google Scholar
    • Export Citation
  • 12.

    Pan B, Deng S, Liao W, Pan W, 2013. Endemic mycoses: overlooked diseases in China. Clin Infect Dis 56: 15161517.

  • 13.

    Lyon GM, Bravo AV, Espino A, Lindsley MD, Gutierrez RE, Rodriguez I, Corella A, Carrillo F, McNeil MM, Warnock DW, Hajjeh RA, 2004. Histoplasmosis associated with exploring a bat-inhabited cave in Costa Rica, 1998–1999. Am J Trop Med Hyg 70: 438442.

    • Search Google Scholar
    • Export Citation
  • 14.

    Murata Y, Sano A, Ueda Y, Inomata T, Takayama A, Poonwan N, Nanthawan M, Mikami Y, Miyaji M, Nishimura K, Kamei K, 2007. Molecular epidemiology of canine histoplasmosis in Japan. Med Mycol 45: 233247.

    • Search Google Scholar
    • Export Citation
 
 
 
 

 

 
 

 

 

 

 

 

 

Detection and Phylogenetic Characterization of a Case of Histoplasma capsulatum Infection in Mainland China

View More View Less
  • Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China

Histoplasmosis usually occurs in specific endemic areas. Sporadic cases have also been reported in mainland China. Here, we described an indigenous case of disseminated histoplasmosis. Phylogenetic analysis revealed that the Histoplasma capsulatum isolated in our case belongs to the Australian clade. Combined with previous studies, it revealed high genetic diversity among Chinese H. capsulatum isolates.

Author Notes

* Address correspondence to Weihua Pan, Department of Dermatology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200433, People's Republic of China, E-mail: panweihua@medmail.com.cn or Jun Gu, Department of Dermatology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, People's Republic of China, E-mail: jungusmmu@gmail.com† These authors contributed equally.

Financial support: This study was supported by National 973 Program Grant 2013CB531600, National Science and Technology Major Projects of China Grant 2013ZX10004612001, Shanghai Science and Technology Committee Grant 10dz2220100, and a key project from Chinese Military Logistics (AWS11L009).

Authors' addresses: Ying Wang, Jianhua Wu, Xinling Bi, and Jun Gu, Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China, E-mails: wangying88_2@hotmail.com, 44434731@qq.com, bxlsmmu@gmail.com, and jungusmmu@gmail.com. Bo Pan, Wanqing Liao, and Weihua Pan, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China, E-mails: simajiangtailangpb@hotmail.com, liaowanqing@sohu.com, and panweihua@medmail.com.cn.

Save