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Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon

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  • Secretaria de Saúde do Estado de Rondônia (Hospital Cemetron), Porto Velho, Rondônia, Brazil; Faculdade São Lucas, Porto Velho, Rondônia, Brasil; Universidade Federal de São João Del Rei, Campus Divinópolis, Minas Gerais, Brazil; Fundação Oswaldo Cruz, Fiocruz-Rondônia, Porto Velho, Rondônia, Brazil; Universidade Federal de Rondônia, Porto Velho, Rondônia, Brazil; Departamento de Parasitologia, Instituto de Ciências Biomédicas 5, Universidade de São Paulo, São Paulo, Brazil
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Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.

Author Notes

* Address correspondence to Luís Marcelo Aranha Camargo, Departamento de Parasitologia, Instituto de Ciências Biomédicas 5, Rua Francisco Prestes 1234, Monte Negro, Rondônia CEP 76888-000, Brazil. E-mail: spider@icbusp.org

Financial support: This study was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (grant no. 2008/10817-6).

Authors' addresses: Sergio de Almeida Basano, Secretaria de Saúde do Estado de Rondônia, Porto Velho, Rondônia, Brazil, and Faculdade São Lucas, Departamento de Medicina, Porto Velho, Rondônia, Brazil, E-mail: sergio@icbusp.org. Gilberto Fontes, Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil, E-mail: gilberto.fontes@pq.cnpq.br. Jansen Fernandes Medeiros and Ricardo de Godoi Mattos Ferreira, Fundação Oswaldo Cruz, Fiocruz-Rondônia, Porto Velho, Rondônia, Brazil, E-mails: jmedeiro@gmail.com and ricardogodoi@fiocruz.br. Juliana Souza de Almeida Aranha Camargo, Luana Janaína Souza Vera, Marcos Paulo Parente Araújo, and Maira Santiago Pires Parente, Faculdade São Lucas, Porto Velho, Rondônia, Brazil, E-mails: juliana@icbusp.org, janaina@icbusp.org, marcos_medppa@hotmail.com, and maira_s_pires@hotmail.com. Pedro di Tárique Barreto Crispim, Universidade Federal de Rondônia, Porto Velho, Rondônia, Brazil. Luís Marcelo Aranha Camargo, Faculdade São Lucas, Departamento de Medicina, Porto Velho, Rondônia, Brasil, and Departamento de Parasitologia, Instituto de Ciências Biomédicas 5, Universidade de São Paulo, São Paulo, Brazil, E-mail: spider@icbusp.org.

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