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-
1.
Kappe SH, Vaughan AM, Boddey JA, Cowman AF, 2010. That was then but this is now: malaria research in the time of an eradication agenda. Science 328: 862–866.
-
2.
Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH, 2013. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Rep 3: 630–637.
-
3.
Vogelstein B, Lane D, Levine AJ, 2000. Surfing the p53 network. Nature 408: 307–310.
-
4.
Vousden KH, Lane DP, 2007. p53 in health and disease. Nat Rev Mol Cell Biol 8: 275–283.
-
5.
Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M, 2003. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33: 357–365.
-
6.
Whibley C, Pharoah PDP, Hollstein M, 2009. P53 polymorphisms: cancer implications. Nat Rev Cancer 9: 95–107.
-
7.
Gloria-Bottini F, Meloni G, 2013. P53 codon 72 and past malaria morbidity in Sardinia. Malar Chemoth Cont Elimination 2: 1.
-
8.
Mockenhaupt FP, Bedu-Addo G, von Gaertner C, Boyé R, Fricke K, Hannibal I, Karakaya F, Schaller M, Ulmen U, Acquah PA, Dietz E, Eggelte TA, Bienzle U, 2006. Detection and clinical manifestation of placental malaria in southern Ghana. Malar J 5: 119.
-
9.
Gahutu JB, Steininger C, Shyirambere C, Zeile I, Cwinya-Ay N, Danquah I, Larsen CH, Eggelte TA, Uwimana A, Karema C, Musemakweri A, Harms G, Mockenhaupt FP, 2011. Prevalence and risk factors of malaria among children in southern highland Rwanda. Malar J 10: 134.
-
10.
Ricks-Santi L, Mason T, Apprey V, Ahaghotu C, McLauchlin A, Josey D, Bonney G, Dunston GM, 2010. p53 Pro72 Arg polymorphism and prostate cancer in men of African descent. Prostate 70: 1739–1745.
-
11.
Beckman G, Birgander R, Själander A, Saha N, Holmberg PA, Kivelä A, Beckman L, 1994. Is p53 polymorphism maintained by natural selection? Hum Hered 44: 266–270.
-
12.
Själander A, Birgander R, Saha N, Beckman L, Beckman G, 1996. p53 polymorphisms and haplotypes show distinct differences between major ethnic groups. Hum Hered 46: 41–48.
-
13.
Kang HJ, Feng Z, Sun Y, Atwal G, Murphy ME, Rebbeck TR, Rosenwaks Z, Levine AJ, Hu W, 2009. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci USA 106: 9761–9766.
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No Association of the p53 Codon 72 Polymorphism with Malaria in Ghanaian Primiparae and Rwandan Children
Prabhanjan P. Gai
Prabhanjan P. Gai
Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda
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Stefanie Meese
Stefanie Meese
Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda
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George Bedu-Addo
George Bedu-Addo
Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda
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Jean Bosco Gahutu
Jean Bosco Gahutu
Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda
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Frank P. Mockenhaupt
Frank P. Mockenhaupt
Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda
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The p53 protein is a key cell-signaling mediator integrating host responses to various types of stress. A common polymorphism of the encoding TP53 gene (codon 72, Pro > Arg, rs1042522) is associated with susceptibility to virus-related and other cancers. The p53 has also been shown to be central for successful Plasmodium liver stage infection. We examined whether the polymorphism is associated with P. falciparum infection in Ghanaian primiparae and Rwandan children. The allele frequency of TP53 codon 72 Arg was 0.30 among 314 Ghanaian primiparae and 0.31 among 545 Rwandan children, respectively, and it was not associated with infection prevalence or parasite density. This does not exclude p53 to be of pathophysiological relevance in malaria but argues against a major respective role of the TP53 codon 72 polymorphism.
Author Notes
Financial support: This work was supported by Charité–University Medicine Berlin (grants 2000-512, 2001-613), Deutsche Forschungsgemeinschaft (grants GRK1673/B7[1] to S.M. and B7[2] to P.P.G.), and Sonnenfeld Foundation (S.M.).
Authors' addresses: Prabhanjan P. Gai, Stefanie Meese, and Frank P. Mockenhaupt, Institute of Tropical Medicine and International Health, Charité–Universitätsmedzin Berlin, Berlin, Germany, E-mails: prabhanjan.gai@charite.de, stefanie.messe@charite.de, and frank.mockenhaupt@charite.de. George Bedu-Addo, Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, E-mail: gbeduaddo@gmail.com. Jean Bosco Gahutu, Butare University Teaching Hospital, School of Medicine, University of Rwanda, Huye, Rwanda, E-mail: jgahutu@nur.ac.rw.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Kappe SH, Vaughan AM, Boddey JA, Cowman AF, 2010. That was then but this is now: malaria research in the time of an eradication agenda. Science 328: 862–866.
-
2.
Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH, 2013. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Rep 3: 630–637.
-
3.
Vogelstein B, Lane D, Levine AJ, 2000. Surfing the p53 network. Nature 408: 307–310.
-
4.
Vousden KH, Lane DP, 2007. p53 in health and disease. Nat Rev Mol Cell Biol 8: 275–283.
-
5.
Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M, 2003. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33: 357–365.
-
6.
Whibley C, Pharoah PDP, Hollstein M, 2009. P53 polymorphisms: cancer implications. Nat Rev Cancer 9: 95–107.
-
7.
Gloria-Bottini F, Meloni G, 2013. P53 codon 72 and past malaria morbidity in Sardinia. Malar Chemoth Cont Elimination 2: 1.
-
8.
Mockenhaupt FP, Bedu-Addo G, von Gaertner C, Boyé R, Fricke K, Hannibal I, Karakaya F, Schaller M, Ulmen U, Acquah PA, Dietz E, Eggelte TA, Bienzle U, 2006. Detection and clinical manifestation of placental malaria in southern Ghana. Malar J 5: 119.
-
9.
Gahutu JB, Steininger C, Shyirambere C, Zeile I, Cwinya-Ay N, Danquah I, Larsen CH, Eggelte TA, Uwimana A, Karema C, Musemakweri A, Harms G, Mockenhaupt FP, 2011. Prevalence and risk factors of malaria among children in southern highland Rwanda. Malar J 10: 134.
-
10.
Ricks-Santi L, Mason T, Apprey V, Ahaghotu C, McLauchlin A, Josey D, Bonney G, Dunston GM, 2010. p53 Pro72 Arg polymorphism and prostate cancer in men of African descent. Prostate 70: 1739–1745.
-
11.
Beckman G, Birgander R, Själander A, Saha N, Holmberg PA, Kivelä A, Beckman L, 1994. Is p53 polymorphism maintained by natural selection? Hum Hered 44: 266–270.
-
12.
Själander A, Birgander R, Saha N, Beckman L, Beckman G, 1996. p53 polymorphisms and haplotypes show distinct differences between major ethnic groups. Hum Hered 46: 41–48.
-
13.
Kang HJ, Feng Z, Sun Y, Atwal G, Murphy ME, Rebbeck TR, Rosenwaks Z, Levine AJ, Hu W, 2009. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci USA 106: 9761–9766.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 23 | 23 | 13 |
| Full Text Views | 250 | 67 | 0 |
| PDF Downloads | 56 | 9 | 0 |