No Association of the p53 Codon 72 Polymorphism with Malaria in Ghanaian Primiparae and Rwandan Children

Prabhanjan P. Gai Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda

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Stefanie Meese Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda

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George Bedu-Addo Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda

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Jean Bosco Gahutu Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda

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Frank P. Mockenhaupt Institute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; University Teaching Hospital of Butare, School of Medicine, University of Rwanda, Huye, Rwanda

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The p53 protein is a key cell-signaling mediator integrating host responses to various types of stress. A common polymorphism of the encoding TP53 gene (codon 72, Pro > Arg, rs1042522) is associated with susceptibility to virus-related and other cancers. The p53 has also been shown to be central for successful Plasmodium liver stage infection. We examined whether the polymorphism is associated with P. falciparum infection in Ghanaian primiparae and Rwandan children. The allele frequency of TP53 codon 72 Arg was 0.30 among 314 Ghanaian primiparae and 0.31 among 545 Rwandan children, respectively, and it was not associated with infection prevalence or parasite density. This does not exclude p53 to be of pathophysiological relevance in malaria but argues against a major respective role of the TP53 codon 72 polymorphism.

Author Notes

* Address correspondence to Frank P. Mockenhaupt, Institute of Tropical Medicine and International Health, Charité–Universitätsmedzin Berlin, Spandauer Damm 130, 14050 Berlin, Germany. E-mail: frank.mockenhaupt@charite.de

Financial support: This work was supported by Charité–University Medicine Berlin (grants 2000-512, 2001-613), Deutsche Forschungsgemeinschaft (grants GRK1673/B7[1] to S.M. and B7[2] to P.P.G.), and Sonnenfeld Foundation (S.M.).

Authors' addresses: Prabhanjan P. Gai, Stefanie Meese, and Frank P. Mockenhaupt, Institute of Tropical Medicine and International Health, Charité–Universitätsmedzin Berlin, Berlin, Germany, E-mails: prabhanjan.gai@charite.de, stefanie.messe@charite.de, and frank.mockenhaupt@charite.de. George Bedu-Addo, Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, E-mail: gbeduaddo@gmail.com. Jean Bosco Gahutu, Butare University Teaching Hospital, School of Medicine, University of Rwanda, Huye, Rwanda, E-mail: jgahutu@nur.ac.rw.

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