Author:
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Reference Manager
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-
1.
Gay F, Zougbede S, N'dilimabaka N, Rebollo A, Mazier D, Moreno A, 2012. Cerebral malaria: what is known and what is on research. Rev Neurol (Paris) 168: 239–256.
-
2.
Chipeta J, Mharakurwa S, Thuma P, Kumar N, 2009. A synopsis of current malaria diagnosis trends. Med J Zambia 36: 2.
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3.
Hopkins H, Talisuna A, Whitty CJM, Staedke SG, 2007. Impact of home based management of malaria on health outcomes in Africa: a systematic review of the evidence. Malar J 6: 134.
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4.
World Health Organization, 2008. World Malaria Report. Available at: http://www.who.int/malaria/wmr2008/malaria2008.pdf. Accessed September 10, 2011.
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5.
Warsame M, Kimbute O, Machinda Z, Ruddy P, Melkisedick M, 2007. Recognition, perceptions and treatment practices for severe malaria in rural Tanzania: implications for accessing rectal artesunate as a pre-referral. PLoS ONE 2: e149.
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6.
Polage CA, Quinn TR, Ronald AR, Merle A, Sande MA, 2006. Laboratory medicine in Africa: a barrier to effective health care. Clin Infect Dis 42: 377–382.
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7.
Berhane Y, Demissie M, Lemma S, Worku N, Deressa W, 2009. Qualitative Study on Malaria Prevention and Control in Oromia and Amhara Regional States in Ethiopia, Addis Continental Institute of Public Health. Available at: addiscontinental.edu.et/files/aciph_malaria_qualitative.pdf. Accessed June 24, 2011.
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8.
FMOH, 2005. Malaria Diagnosis and Treatment Guidelines for Health Workers in Ethiopia, 2nd Edition. 2004, Federal Democratic Republic of Ethiopia. Available at: cnhde.ei.columbia.edu/files/1/1/2005-AugThu-083137. Accessed September 12, 2011.
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9.
FMOH, 2012. National Malaria Guide Line, 3rd Edition: National Malaria Guide Line-MOH. Available at: www.moh.gov.et/…/National/malaria/guidelines/2012. Accessed July 20, 2011.
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10.
Young MW, 2003. Effective Management of Childhood Malaria at the Community Level: Programme Experience to Guide the Research Agenda, Paper for the WHO Scientific Working Group on Malaria, Geneva, Switzerland, pp 24–27. Available at: www.tropika.net/review/030324-Malaria_8/article. Accessed September 10, 2011.
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11.
Ohrt C, Meara WPO, Remich S, McEvoy P, Ogutu B, Mtalib R, Odera JS, 2008. Pilot assessment of the sensitivity of the malaria thin film. Malar J 7: 22.
-
12.
Moody A, 2002. Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev 15: 66–78.
-
13.
Maltha J, Gillet P, Bottieau E, Cnops L, Esbroeck MV, 2010. Evaluation of a rapid diagnostic test (CareStart™ Malaria HRP-2/pLDH (Pf/pan) Combo Test) for the diagnosis of malaria in a reference setting. Malar J 9: 171.
-
14.
Sharew B, Legesse M, Animut A, Jima D, Medhin G, Erko B, 2009. Evaluation of the performance of CareStartTM Malaria Pf/Pv Combo and Paracheck Pf® tests for the diagnosis of malaria in Wondo Genet, southern Ethiopia. Acta Trop 111: 321–324.
-
15.
Moges B, Amare B, Belyhun Y, Tekeste Z, Gizachew M, 2012. Comparison of CareStart™ HRP2/pLDH COMBO rapid malaria test with light microscopy in north-west Ethiopia. Malar J 11: 234.
-
16.
Harani MS, Beg MA, Khaleeq L, Adil SN, Kakepoto GN, 2006. Role of ICT malaria immunochromatographic test for rapid diagnosis of malaria. J Pak Med Assoc 56: 4.
-
17.
Gerstl S, Dunkley S, Mukhtar A, Smet MD, Baker S, Maikere J, 2010. Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone. Malar J 9: 28.
-
18.
Baiden F, Webster J, Tivura M, Delimini R, Berko Y, 2012. Accuracy of rapid tests for malaria and treatment outcomes for malaria and non-malaria cases among under-five children in rural Ghana. PLoS ONE 7: 4.
-
19.
Sun X, Ernest T, Wei C, Cheng Z, Deng Y, 2013. Diagnostic performance of CareStart™ malaria HRP2/pLDH (Pf/pan) combo test versus standard microscopy on falciparum and vivax malaria between China-Myanmar endemic borders. Malar J 12: 6.
-
20.
WHO, 2003. Malaria rapid diagnosis. Making it work. Proceeding of the Meeting of the World Health Organization, January 20–23, 2003, Manila, The Philippines.
-
21.
Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H, 2008. Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J 7: 221.
-
22.
Ashley EA, Touabi M, Ahrer M, Hutagalung R, Htun K, 2009. Evaluation of three parasite lactate dehydrogenase based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria. Malar J 8: 241.
-
23.
Kaklciaya BS, 2003. Rapid diagnosis of malaria. Lab Med 8: 602–608.
-
24.
Guthmann JP, Ruiz A, Priotto G, Kigula J, Bonte L, Legros D, 2002. Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda. Tran R Soc Trop Med Hyg 96: 254–257.
-
25.
Udomsangpetch R, Webster HK, Pattanapanyasat K, Pitchayangkul S, Thaithong S, 1992. Cytoadherence characteristics of rosette-forming Plasmodium falciparum. Infect Immun 60: 4483–4490.
-
26.
Dondorp AM, Ince C, Charunwatthana P, Hanson J, van Kuijen A, Faiz MA, Rahman MR, Hasan M, Bin Yunus E, Ghose A, Ruangveerayut R, Limmathurotsakul D, Mathura K, White NJ, Day NP, 2008. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis 197: 79–84.
-
27.
Brendan SC, Alen FC, 2002. Plasmodium falciparum virulence determinants unveiled genome. Biology (Basel) 3: 11.
| Past two years | Past Year | Past 30 Days | |
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Assessing the Performance of CareStart Malaria Pf/Pv Combo Test Against Thick Blood Film in the Diagnosis of Malaria in Northwest Ethiopia
Tadesse Hailu
Tadesse Hailu
Department of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia; Department of Microbiology, Immunology and Parasitology (DMIP), School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
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Tadesse Kebede
Tadesse Kebede
Department of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia; Department of Microbiology, Immunology and Parasitology (DMIP), School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
Search for other papers by Tadesse Kebede in
Current site
Google Scholar
PubMed
Search for other papers by Tadesse Kebede in
Current site
Google Scholar
PubMed
Bivalent rapid diagnostic tests are promising diagnostic tools for Plasmodium falciparum and P. vivax. Their diagnostic performance was evaluated against thick blood smear to assist national malaria control programs. A cross-sectional study was conducted to evaluate the performance of CareStart against thick blood smears among 398 acute febrile patients visiting the Felegeselam Health Center in December of 2011. Thick blood smears were examined under 100× objectives to diagnose Plasmodium species. Similarly, CareStart Malaria Pf/Pv Combo Test was performed as per the manufacturer's instruction. The ability of CareStart Malaria Pf/Pv Combo Test to diagnose Plasmodium malaria was very good, with 99.8% (95% confidence interval = 97.7–100%) sensitivity and 97.7% (95% confidence interval = 94.6–99.1%) specificity. The sensitivity and specificity of the CareStart Test is comparable with the thick blood smear in diagnosing malaria. Hence, it is preferable to use the CareStart Malaria Pf/Pv Combo Test instead of microscopy in areas where microscopic diagnosis is limited.
Author Notes
Authors' addresses: Tadesse Hailu, Department of Microbiology, Immunology and Parasitology, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia, E-mail: tadessehailu2005@yahoo.com. Tadesse Kebede, Department of Microbiology, Immunology and Parasitology (DMIP), School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, E-mail: tkas2003@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Gay F, Zougbede S, N'dilimabaka N, Rebollo A, Mazier D, Moreno A, 2012. Cerebral malaria: what is known and what is on research. Rev Neurol (Paris) 168: 239–256.
-
2.
Chipeta J, Mharakurwa S, Thuma P, Kumar N, 2009. A synopsis of current malaria diagnosis trends. Med J Zambia 36: 2.
-
3.
Hopkins H, Talisuna A, Whitty CJM, Staedke SG, 2007. Impact of home based management of malaria on health outcomes in Africa: a systematic review of the evidence. Malar J 6: 134.
-
4.
World Health Organization, 2008. World Malaria Report. Available at: http://www.who.int/malaria/wmr2008/malaria2008.pdf. Accessed September 10, 2011.
-
5.
Warsame M, Kimbute O, Machinda Z, Ruddy P, Melkisedick M, 2007. Recognition, perceptions and treatment practices for severe malaria in rural Tanzania: implications for accessing rectal artesunate as a pre-referral. PLoS ONE 2: e149.
-
6.
Polage CA, Quinn TR, Ronald AR, Merle A, Sande MA, 2006. Laboratory medicine in Africa: a barrier to effective health care. Clin Infect Dis 42: 377–382.
-
7.
Berhane Y, Demissie M, Lemma S, Worku N, Deressa W, 2009. Qualitative Study on Malaria Prevention and Control in Oromia and Amhara Regional States in Ethiopia, Addis Continental Institute of Public Health. Available at: addiscontinental.edu.et/files/aciph_malaria_qualitative.pdf. Accessed June 24, 2011.
-
8.
FMOH, 2005. Malaria Diagnosis and Treatment Guidelines for Health Workers in Ethiopia, 2nd Edition. 2004, Federal Democratic Republic of Ethiopia. Available at: cnhde.ei.columbia.edu/files/1/1/2005-AugThu-083137. Accessed September 12, 2011.
-
9.
FMOH, 2012. National Malaria Guide Line, 3rd Edition: National Malaria Guide Line-MOH. Available at: www.moh.gov.et/…/National/malaria/guidelines/2012. Accessed July 20, 2011.
-
10.
Young MW, 2003. Effective Management of Childhood Malaria at the Community Level: Programme Experience to Guide the Research Agenda, Paper for the WHO Scientific Working Group on Malaria, Geneva, Switzerland, pp 24–27. Available at: www.tropika.net/review/030324-Malaria_8/article. Accessed September 10, 2011.
-
11.
Ohrt C, Meara WPO, Remich S, McEvoy P, Ogutu B, Mtalib R, Odera JS, 2008. Pilot assessment of the sensitivity of the malaria thin film. Malar J 7: 22.
-
12.
Moody A, 2002. Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev 15: 66–78.
-
13.
Maltha J, Gillet P, Bottieau E, Cnops L, Esbroeck MV, 2010. Evaluation of a rapid diagnostic test (CareStart™ Malaria HRP-2/pLDH (Pf/pan) Combo Test) for the diagnosis of malaria in a reference setting. Malar J 9: 171.
-
14.
Sharew B, Legesse M, Animut A, Jima D, Medhin G, Erko B, 2009. Evaluation of the performance of CareStartTM Malaria Pf/Pv Combo and Paracheck Pf® tests for the diagnosis of malaria in Wondo Genet, southern Ethiopia. Acta Trop 111: 321–324.
-
15.
Moges B, Amare B, Belyhun Y, Tekeste Z, Gizachew M, 2012. Comparison of CareStart™ HRP2/pLDH COMBO rapid malaria test with light microscopy in north-west Ethiopia. Malar J 11: 234.
-
16.
Harani MS, Beg MA, Khaleeq L, Adil SN, Kakepoto GN, 2006. Role of ICT malaria immunochromatographic test for rapid diagnosis of malaria. J Pak Med Assoc 56: 4.
-
17.
Gerstl S, Dunkley S, Mukhtar A, Smet MD, Baker S, Maikere J, 2010. Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone. Malar J 9: 28.
-
18.
Baiden F, Webster J, Tivura M, Delimini R, Berko Y, 2012. Accuracy of rapid tests for malaria and treatment outcomes for malaria and non-malaria cases among under-five children in rural Ghana. PLoS ONE 7: 4.
-
19.
Sun X, Ernest T, Wei C, Cheng Z, Deng Y, 2013. Diagnostic performance of CareStart™ malaria HRP2/pLDH (Pf/pan) combo test versus standard microscopy on falciparum and vivax malaria between China-Myanmar endemic borders. Malar J 12: 6.
-
20.
WHO, 2003. Malaria rapid diagnosis. Making it work. Proceeding of the Meeting of the World Health Organization, January 20–23, 2003, Manila, The Philippines.
-
21.
Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H, 2008. Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J 7: 221.
-
22.
Ashley EA, Touabi M, Ahrer M, Hutagalung R, Htun K, 2009. Evaluation of three parasite lactate dehydrogenase based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria. Malar J 8: 241.
-
23.
Kaklciaya BS, 2003. Rapid diagnosis of malaria. Lab Med 8: 602–608.
-
24.
Guthmann JP, Ruiz A, Priotto G, Kigula J, Bonte L, Legros D, 2002. Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda. Tran R Soc Trop Med Hyg 96: 254–257.
-
25.
Udomsangpetch R, Webster HK, Pattanapanyasat K, Pitchayangkul S, Thaithong S, 1992. Cytoadherence characteristics of rosette-forming Plasmodium falciparum. Infect Immun 60: 4483–4490.
-
26.
Dondorp AM, Ince C, Charunwatthana P, Hanson J, van Kuijen A, Faiz MA, Rahman MR, Hasan M, Bin Yunus E, Ghose A, Ruangveerayut R, Limmathurotsakul D, Mathura K, White NJ, Day NP, 2008. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis 197: 79–84.
-
27.
Brendan SC, Alen FC, 2002. Plasmodium falciparum virulence determinants unveiled genome. Biology (Basel) 3: 11.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 16 | 16 | 5 |
| Full Text Views | 330 | 103 | 0 |
| PDF Downloads | 99 | 26 | 0 |