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Usefulness of Strongyloides stercoralis Serology in the Management of Patients with Eosinophilia

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  • Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain

Strongyloides stercoralis infection is being increasingly diagnosed out of endemic areas. The aim of this study is to evaluate the usefulness of S. stercoralis serology for the management of probable strongyloidiasis in patients presenting with eosinophilia. Overall, 147 patients were included, 89 (60.5%) patients had a positive S. stercoralis serology. Strongyloides stercoralis larvae were detected only in 15 (10.2%) patients. Twenty-eight patients had human immunodeficiency virus infection. Eighty patients received ivermectin 200 mcg/Kg/day for 2 days, and follow-up 6 months after treatment could be performed in 32 patients: 26 (81.3%) patients reached the response to treatment criteria (negative serology 6 months after treatment or when by enzyme-linked immunosorbent assay the optical density ratio of post-treatment to pre-treatment decreased to 0.6), and 11 (34.4%) patients fulfilled the cure criteria (negative serology 6 months after treatment). Strongyloides stercoralis serology is a useful diagnostic tool both in the diagnosis of probable strongyloidiasis and follow-up after treatment.

Author Notes

* Address correspondence to Fernando Salvador, Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Passeig Vall d'Hebron 119-129, Barcelona, Spain. E-mail: fmsalvad@vhebron.net

Financial support: This study was supported by the 6th National Plan (PN) of Research + Development + Innovation (I + D + I) 2008–2011, Carlos III Health Institute (ISCIII) General Division Networks and Cooperative Research Centres + Collaborative Research Network on Tropical Diseases (RICET). RD12/0018/0020 and RD12/0018/0011 are the codes of the two collaborative centres (Vall d'Hebron Teaching Hospital and the National Centre of Microbiology).

Authors' addresses: Fernando Salvador, Albert Pahissa, and Israel Molina, Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mails: fmsalvad@vhebron.net, apahissa@vhebron.net, and imolina@vhebron.net. Elena Sulleiro, Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mail: esuillig@gmail.com. Adrián Sánchez-Montalvá, Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mail: adrian.sanchez.montalva@gmail.com. José María Saugar, Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain, E-mail: jmsaugar@isciii.es. Esperanza Rodríguez, Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain, E-mail: erodrgez@isciii.es.

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