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RefWorks
Reference Manager
BibTeX
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-
1.
Barnett ED, Weld LH, McCarthy AE, So H, Walker PF, Stauffer W, Cetron M; GeoSentinel Surveillance Network, 2013. Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997–2009, part 1: US-bound migrants evaluated by comprehensive protocol-based health assessment. Clin Infect Dis 56: 913–924.
-
2.
World Health Organization, Strongyloidiasis. Available at: www.who.int/neglected_diseases/diseases/strongyloidiasis/en/. Accessed November 1, 2013.
-
3.
Repetto SA, Durán PA, Lasala MB, González-Cappa SM, 2010. High rate of Strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections. Am J Trop Med Hyg 82: 1088–1093.
-
4.
Keiser PB, Nutman TB, 2004. Strongyloides stercoralis in the immunocompromised population. Clin Microbiol Rev 17: 208–217.
-
5.
Siddiqui AA, Berck SL, 2001. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis 33: 1040–1047.
-
6.
Kobayashi J, Sato Y, Toma H, Takara M, Shiroma Y, 1994. Application of enzyme immunoassay for postchemotherapy evaluation of human strongyloidiasis. Diagn Microbiol Infect Dis 18: 19–23.
-
7.
Biggs BA, Caruana S, Mihrshahi S, Jolley D, Leydon J, Chea L, Nuon S, 2009. Short report: management of chronic strongyloidiasis in immigrants and refugees: is serologic testing useful? Am J Trop Med Hyg 80: 788–791.
-
8.
Bon B, Houze S, Talabani H, Magne D, Belkadi G, Develoux M, Senghor Y, Chandenier J, Ancelle T, Hennequin C, 2010. Evaluation of a rapid enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis. J Clin Microbiol 48: 1716–1719.
-
9.
Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong S, Karuphong E, Anekthananon T, Wanachiwanawin D, Silpasakorn S, 2011. Efficacy and safety of single and double doses of Ivermectin versus 7-day high dose Albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis 5: e1044.
-
10.
Díaz-Menéndez M, Pérez-Molina JA, Serre N, Treviño B, Torrús D, Matarranz M, Martín E, Rojo-Marcos G, Aguilera P, Rico A, Suárez-García I, López-Vélez R; Grupo de trabajo + Redivi, 2012. Imported diseases by immigrants and travelers: results from the Cooperative Network for the study of Imported Diseases by Immigrants and Travelers + Redivi. Enferm Infecc Microbiol Clin 30: 528–534.
-
11.
Valerio L, Roure S, Fernández-Rivas G, Basile L, Martínez-Cuevas O, Ballesteros AL, Ramos X, Sabrià M; North Metropolitan Working Group on Imported Diseases, 2013. Strongyloides stercoralis, the hidden worm. Epidemiological and clinical characteristics of 70 cases diagnosed in the North Metropolitan Area of Barcelona, Spain, 2003–2012. Trans R Soc Trop Med Hyg 107: 465–470.
-
12.
Dreyer G, Fernandes-Silva E, Alves S, Rocha A, Albuquerque R, Addiss D, 1996. Patterns of detection of Strongyloides stercoralis in stool specimens: implications for diagnosis and clinical trials. J Clin Microbiol 34: 2569–2571.
-
13.
Uparanukraw P, Phongsri S, Morakote N, 1999. Fluctuations of larval excretion in Strongyloides stercoralis infection. Am J Trop Med Hyg 60: 967–973.
-
14.
Nielsen PB, Mojon M, 1987. Improved diagnosis of Strongyloides stercoralis by seven consecutive stool specimens. Zentralbl Bakteriol Mikrobiol Hyg [A] 263: 616–618.
-
15.
Requena-Méndez A, Chiodini P, Bisoffi Z, Buonfrate D, Gotuzzo E, Muñoz J, 2013. The laboratory diagnosis and follow-up of strongyloidiasis: a systematic review. PLoS Negl Trop Dis 7: e2002.
-
16.
Abdul-Fattah MM, Nasr ME, Yousef SM, Ibraheem MI, Abdul-Wahhab SE, Soliman HM, 1995. Efficacy of ELISA in diagnosis of strongyloidiasis among the immune-compromised patients. J Egypt Soc Parasitol 25: 491–498.
-
17.
Salvador F, Molina I, Sulleiro E, Burgos J, Curran A, Van den Eynde E, Villar del Saz S, Navarro J, Crespo M, Ocaña I, Ribera E, Falcó V, Pahissa A, 2013. Tropical diseases screening in immigrant patients with HIV infection in a European country. Am J Trop Med Hyg 88: 1196–1202.
-
18.
Llenas-García J, Fiorante S, Salto E, Maseda D, Rodríguez V, Matarranz M, Hernando A, Rubio R, Pulido F, 2013. Should we look for Strongyloides stercoralis in foreign-born HIV-infected persons? J Immigr Minor Health 15: 796–802.
-
19.
Karunajeewa H, Kelly H, Leslie D, Leydon J, Saykao P, Biggs BA, 2006. Parasite-specific IgG response and peripheral blood eosinophil count following albendazole treatment for presumed chronic strongyloidiasis. J Travel Med 13: 84–91.
-
20.
Page WA, Dempsey K, McCarthy JS, 2006. Utility of serological follow-up of chronic strongyloidiasis after anthelminthic chemotherapy. Trans R Soc Trop Med Hyg 100: 1056–1062.
-
21.
Lindo JF, Atkins NS, Lee MG, Robinson RD, Bundy DAP, 1996. Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. Trans R Soc Trop Med Hyg 90: 702–703.
-
22.
Loutfy MR, Wilson M, Keystone JS, Kain KC, 2002. Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area. Am J Trop Med Hyg 66: 749–752.
-
23.
Bisoffi Z, Buonfrate D, Angheben A, Boscolo M, Anselmi M, Marocco S, Monteiro G, Gobbo M, Bisoffi G, Gobbi F, 2011. Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis. PLoS Negl Trop Dis 5: e1254.
-
24.
Krolewiecki AJ, Ramanathan R, Fink V, McAuliffe I, Cajal SP, Won K, Juarez M, Di Paolo A, Tapia L, Acosta N, Lee R, Lammie P, Abraham D, Nutman TB, 2010. Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in Northern Argentina. Vaccine Immunol 17: 1624–1630.
-
25.
El-Badry AA, 2009. ELISA-based coproantigen in human strongyloidiasis: a diagnostic method correlating with worm burden. J Egypt Soc Parasitol 39: 757–768.
-
26.
Kramme S, Nissen N, Soblik H, Erttmann K, Tannich E, Fleisher B, Panning M, Brattig N, 2011. Novel real-time PCR for the universal detection of Strongyloides species. J Med Microbiol 60: 454–458.
-
27.
Verweij JJ, Canales M, Polman K, Ziem J, Brienen EA, Polderman AM, van Lieshout L, 2009. Molecular diagnosis of Strongyloides stercoralis in fecal samples using real-time PCR. Trans R Soc Trop Med Hyg 103: 342–346.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2847 | 2248 | 511 |
| Full Text Views | 538 | 20 | 1 |
| PDF Downloads | 244 | 18 | 0 |
Usefulness of Strongyloides stercoralis Serology in the Management of Patients with Eosinophilia
Fernando Salvador
Fernando Salvador
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Elena Sulleiro
Elena Sulleiro
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Adrián Sánchez-Montalvá
Adrián Sánchez-Montalvá
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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José María Saugar
José María Saugar
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Esperanza Rodríguez
Esperanza Rodríguez
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Albert Pahissa
Albert Pahissa
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Israel Molina
Israel Molina
Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona; Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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Strongyloides stercoralis infection is being increasingly diagnosed out of endemic areas. The aim of this study is to evaluate the usefulness of S. stercoralis serology for the management of probable strongyloidiasis in patients presenting with eosinophilia. Overall, 147 patients were included, 89 (60.5%) patients had a positive S. stercoralis serology. Strongyloides stercoralis larvae were detected only in 15 (10.2%) patients. Twenty-eight patients had human immunodeficiency virus infection. Eighty patients received ivermectin 200 mcg/Kg/day for 2 days, and follow-up 6 months after treatment could be performed in 32 patients: 26 (81.3%) patients reached the response to treatment criteria (negative serology 6 months after treatment or when by enzyme-linked immunosorbent assay the optical density ratio of post-treatment to pre-treatment decreased to 0.6), and 11 (34.4%) patients fulfilled the cure criteria (negative serology 6 months after treatment). Strongyloides stercoralis serology is a useful diagnostic tool both in the diagnosis of probable strongyloidiasis and follow-up after treatment.
Author Notes
Financial support: This study was supported by the 6th National Plan (PN) of Research + Development + Innovation (I + D + I) 2008–2011, Carlos III Health Institute (ISCIII) General Division Networks and Cooperative Research Centres + Collaborative Research Network on Tropical Diseases (RICET). RD12/0018/0020 and RD12/0018/0011 are the codes of the two collaborative centres (Vall d'Hebron Teaching Hospital and the National Centre of Microbiology).
Authors' addresses: Fernando Salvador, Albert Pahissa, and Israel Molina, Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mails: fmsalvad@vhebron.net, apahissa@vhebron.net, and imolina@vhebron.net. Elena Sulleiro, Department of Microbiology, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mail: esuillig@gmail.com. Adrián Sánchez-Montalvá, Department of Infectious Diseases, Vall d'Hebron Teaching Hospital, Barcelona, Spain, PROSICS Barcelona, E-mail: adrian.sanchez.montalva@gmail.com. José María Saugar, Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain, E-mail: jmsaugar@isciii.es. Esperanza Rodríguez, Department of Parasitology, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain, E-mail: erodrgez@isciii.es.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Barnett ED, Weld LH, McCarthy AE, So H, Walker PF, Stauffer W, Cetron M; GeoSentinel Surveillance Network, 2013. Spectrum of illness in international migrants seen at GeoSentinel clinics in 1997–2009, part 1: US-bound migrants evaluated by comprehensive protocol-based health assessment. Clin Infect Dis 56: 913–924.
-
2.
World Health Organization, Strongyloidiasis. Available at: www.who.int/neglected_diseases/diseases/strongyloidiasis/en/. Accessed November 1, 2013.
-
3.
Repetto SA, Durán PA, Lasala MB, González-Cappa SM, 2010. High rate of Strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections. Am J Trop Med Hyg 82: 1088–1093.
-
4.
Keiser PB, Nutman TB, 2004. Strongyloides stercoralis in the immunocompromised population. Clin Microbiol Rev 17: 208–217.
-
5.
Siddiqui AA, Berck SL, 2001. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis 33: 1040–1047.
-
6.
Kobayashi J, Sato Y, Toma H, Takara M, Shiroma Y, 1994. Application of enzyme immunoassay for postchemotherapy evaluation of human strongyloidiasis. Diagn Microbiol Infect Dis 18: 19–23.
-
7.
Biggs BA, Caruana S, Mihrshahi S, Jolley D, Leydon J, Chea L, Nuon S, 2009. Short report: management of chronic strongyloidiasis in immigrants and refugees: is serologic testing useful? Am J Trop Med Hyg 80: 788–791.
-
8.
Bon B, Houze S, Talabani H, Magne D, Belkadi G, Develoux M, Senghor Y, Chandenier J, Ancelle T, Hennequin C, 2010. Evaluation of a rapid enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis. J Clin Microbiol 48: 1716–1719.
-
9.
Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong S, Karuphong E, Anekthananon T, Wanachiwanawin D, Silpasakorn S, 2011. Efficacy and safety of single and double doses of Ivermectin versus 7-day high dose Albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis 5: e1044.
-
10.
Díaz-Menéndez M, Pérez-Molina JA, Serre N, Treviño B, Torrús D, Matarranz M, Martín E, Rojo-Marcos G, Aguilera P, Rico A, Suárez-García I, López-Vélez R; Grupo de trabajo + Redivi, 2012. Imported diseases by immigrants and travelers: results from the Cooperative Network for the study of Imported Diseases by Immigrants and Travelers + Redivi. Enferm Infecc Microbiol Clin 30: 528–534.
-
11.
Valerio L, Roure S, Fernández-Rivas G, Basile L, Martínez-Cuevas O, Ballesteros AL, Ramos X, Sabrià M; North Metropolitan Working Group on Imported Diseases, 2013. Strongyloides stercoralis, the hidden worm. Epidemiological and clinical characteristics of 70 cases diagnosed in the North Metropolitan Area of Barcelona, Spain, 2003–2012. Trans R Soc Trop Med Hyg 107: 465–470.
-
12.
Dreyer G, Fernandes-Silva E, Alves S, Rocha A, Albuquerque R, Addiss D, 1996. Patterns of detection of Strongyloides stercoralis in stool specimens: implications for diagnosis and clinical trials. J Clin Microbiol 34: 2569–2571.
-
13.
Uparanukraw P, Phongsri S, Morakote N, 1999. Fluctuations of larval excretion in Strongyloides stercoralis infection. Am J Trop Med Hyg 60: 967–973.
-
14.
Nielsen PB, Mojon M, 1987. Improved diagnosis of Strongyloides stercoralis by seven consecutive stool specimens. Zentralbl Bakteriol Mikrobiol Hyg [A] 263: 616–618.
-
15.
Requena-Méndez A, Chiodini P, Bisoffi Z, Buonfrate D, Gotuzzo E, Muñoz J, 2013. The laboratory diagnosis and follow-up of strongyloidiasis: a systematic review. PLoS Negl Trop Dis 7: e2002.
-
16.
Abdul-Fattah MM, Nasr ME, Yousef SM, Ibraheem MI, Abdul-Wahhab SE, Soliman HM, 1995. Efficacy of ELISA in diagnosis of strongyloidiasis among the immune-compromised patients. J Egypt Soc Parasitol 25: 491–498.
-
17.
Salvador F, Molina I, Sulleiro E, Burgos J, Curran A, Van den Eynde E, Villar del Saz S, Navarro J, Crespo M, Ocaña I, Ribera E, Falcó V, Pahissa A, 2013. Tropical diseases screening in immigrant patients with HIV infection in a European country. Am J Trop Med Hyg 88: 1196–1202.
-
18.
Llenas-García J, Fiorante S, Salto E, Maseda D, Rodríguez V, Matarranz M, Hernando A, Rubio R, Pulido F, 2013. Should we look for Strongyloides stercoralis in foreign-born HIV-infected persons? J Immigr Minor Health 15: 796–802.
-
19.
Karunajeewa H, Kelly H, Leslie D, Leydon J, Saykao P, Biggs BA, 2006. Parasite-specific IgG response and peripheral blood eosinophil count following albendazole treatment for presumed chronic strongyloidiasis. J Travel Med 13: 84–91.
-
20.
Page WA, Dempsey K, McCarthy JS, 2006. Utility of serological follow-up of chronic strongyloidiasis after anthelminthic chemotherapy. Trans R Soc Trop Med Hyg 100: 1056–1062.
-
21.
Lindo JF, Atkins NS, Lee MG, Robinson RD, Bundy DAP, 1996. Parasite-specific serum IgG following successful treatment of endemic strongyloidiasis using ivermectin. Trans R Soc Trop Med Hyg 90: 702–703.
-
22.
Loutfy MR, Wilson M, Keystone JS, Kain KC, 2002. Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area. Am J Trop Med Hyg 66: 749–752.
-
23.
Bisoffi Z, Buonfrate D, Angheben A, Boscolo M, Anselmi M, Marocco S, Monteiro G, Gobbo M, Bisoffi G, Gobbi F, 2011. Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis. PLoS Negl Trop Dis 5: e1254.
-
24.
Krolewiecki AJ, Ramanathan R, Fink V, McAuliffe I, Cajal SP, Won K, Juarez M, Di Paolo A, Tapia L, Acosta N, Lee R, Lammie P, Abraham D, Nutman TB, 2010. Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in Northern Argentina. Vaccine Immunol 17: 1624–1630.
-
25.
El-Badry AA, 2009. ELISA-based coproantigen in human strongyloidiasis: a diagnostic method correlating with worm burden. J Egypt Soc Parasitol 39: 757–768.
-
26.
Kramme S, Nissen N, Soblik H, Erttmann K, Tannich E, Fleisher B, Panning M, Brattig N, 2011. Novel real-time PCR for the universal detection of Strongyloides species. J Med Microbiol 60: 454–458.
-
27.
Verweij JJ, Canales M, Polman K, Ziem J, Brienen EA, Polderman AM, van Lieshout L, 2009. Molecular diagnosis of Strongyloides stercoralis in fecal samples using real-time PCR. Trans R Soc Trop Med Hyg 103: 342–346.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2847 | 2248 | 511 |
| Full Text Views | 538 | 20 | 1 |
| PDF Downloads | 244 | 18 | 0 |