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Schistosomiasis Does Not Affect the Outcome of HCV Infection in Genotype 4-Infected Patients

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  • Egyptian Company for Blood Transfusion Services (Egyblood), Agouza, Giza, Egypt; Department of Microbiology, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt; Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt; South Egypt Cancer Institute, Assuit, Egypt; Department of Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt

Although reports suggest that Schistosoma mansoni increases hepatitis C virus (HCV) morbidity and chronicity, its impact on HCV spontaneous resolution is not clear. HCV genotype, viral load, abdominal ultrasonographic findings, and HCV-specific cell-mediated immunity (CMI) were examined among 141 healthcare workers infected with HCV (68 workers with and 73 workers without S. mansoni). HCV genotype 4 was dominate, and viral loads were 2.62 ± 0.69 × 106 and 4.24 ± 1.4 × 106 IU/mL among patients with and without coinfection, respectively (P = 0.309); 23.5% with and 32.9% without coinfection had spontaneously resolved HCV infection (P = 0.297). Interferon-γ spot-forming cells/106 peripheral blood mononuclear cells among responding viremic patients with and without coinfection were 716 ± 194 and 587 ± 162, whereas among aviremic patients, it was 794 ± 272 and 365 ± 36 (P > 0.05), respectively. In conclusion, there was no statistical difference in HCV spontaneous resolution, viral load, liver pathology, or CMI in patients with or without S. mansoni coinfection, suggesting that it did not impact the outcome of HCV infection.

Author Notes

* Address correspondence to Sayed F. Abdelwahab, Department of Microbiology and Immunology, Faculty of Medicine, Minia University, Minia 61511, Egypt. E-mail: sayed.awahab@mu.edu.eg

Financial support: This study was supported by European Union 6th Framework Program Contract no. 0374435 to the HEPACIVAC Consortium and the Egyptian Company for Blood Transfusion Services (Egyblood).

Authors' addresses: Walaa R. Allam, Zainab Zakaria, and Gehan Galal, Egyptian Company for Blood Transfusion Services (Egyblood), Agouza, Giza, Egypt, E-mails: walaaramadan@gmail.com, zainab_ali52@hotmail.com, and gehan_galal@hotmail.com. Ahmed Barakat, Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt, E-mail: barakat.ainshams@gmail.com. Tamer S. Abdel-Ghafar, Mohamed El-Tabbakh, and Imam Waked, Department of Hepatology, National Liver Institute, Menoufiya University, Menoufiya, Egypt, E-mails: tamerghfar@yahoo.com, meltabbakh@liver-eg.org, and iwaked@liver-eg.org. Nabeil Mikhail, South Egypt Cancer Institute, Assuit, Egypt, E-mail: nabiel.mikhail@gmail.com. Sayed F. Abdelwahab, Department of Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt, E-mail: sayed.awahab@mu.edu.eg.

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