Budke CM, Deplazes P, Torgerson PR, 2006. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis 12: 296–303.
Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L, 2007. Control of neglected tropical diseases. N Engl J Med 357: 1018–1027.
Seimenis A, 2003. Overview of the epidemiological situation on echinococcosis in the Mediterranean region. Acta Trop 85: 191–195.
Sotiraki S, Himonas C, Korkoliakou P, 2003. Hydatidosis-echinococcosis in Greece. Acta Trop 85: 197–201.
Lorenzini R, Ruggieri A, 1987. Distribution of echinococcosis/hydatidosis in Italy. J Helminthol 61: 261–267.
Rojo-Vazquez FA, Pardo-Lledias J, Francos-Von Hunefeld M, Cordero-Sanchez M, Alamo-Sanz R, Hernandez-Gonzalez A, Brunetti E, Siles-Lucas M, 2011. Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe. PLoS Negl Trop Dis 5: e893.
Pardo J, Muro A, Galindo I, Cordero M, Carpio A, Siles-Lucas M, 2005. Hydatidosis in the province of Salamanca (Spain): should we let down our guard? Enferm Infecc Microbiol Clin 23: 266–269.
Vuitton DA, 2009. Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus? Expert Rev Anti Infect Ther 7: 145–149.
WHO, 1996. Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis. Bull World Health Organ 74: 231–242.
Menezes da Silva A, 2003. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop 85: 237–242.
Smego RA Jr, Sebanego P, 2005. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 9: 69–76.
Silva MA, Mirza DF, Bramhall SR, Mayer AD, McMaster P, Buckels JA, 2004. Treatment of hydatid disease of the liver. Evaluation of a UK experience. Dig Surg 21: 227–233, discussion 233–234.
Pelaez V, Kugler C, Correa D, Del Carpio M, Guangiroli M, Molina J, Marcos B, Lopez E, 2000. PAIR as percutaneous treatment of hydatid liver cysts. Acta Trop 75: 197–202.
Ustunsoz B, Akhan O, Kamiloglu MA, Somuncu I, Ugurel MS, Cetiner S, 1999. Percutaneous treatment of hydatid cysts of the liver: long-term results. AJR Am J Roentgenol 172: 91–96.
Filice C, Brunetti E, Bruno R, Crippa FG, 2000. Percutaneous drainage of echinococcal cysts (PAIR–puncture, aspiration, injection, reaspiration): results of a worldwide survey for assessment of its safety and efficacy. WHO-Informal Working Group on Echinococcosis-Pair Network. Gut 47: 156–157.
Perez-Molina JA, Diaz-Menendez M, Gallego JI, Norman F, Monge-Maillo B, Ayala AP, Lopez-Velez R, 2011. Evaluation of nitazoxanide for the treatment of disseminated cystic echinococcosis: report of five cases and literature review. Am J Trop Med Hyg 84: 351–356.
Mohamed AE, Yasawy MI, Al Karawi MA, 1998. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology 45: 1690–1694.
Yasawy MI, al Karawi MA, Mohamed AR, 1993. Combination of praziquantel and albendazole in the treatment of hydatid disease. Trop Med Parasitol 44: 192–194.
El-On J, 2003. Benzimidazole treatment of cystic echinococcosis. Acta Trop 85: 243–252.
Falagas ME, Bliziotis IA, 2007. Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials. Am J Med Sci 334: 171–179.
Stojkovic M, Zwahlen M, Teggi A, Vutova K, Cretu CM, Virdone R, Nicolaidou P, Cobanoglu N, Junghanss T, 2009. Treatment response of cystic echinococcosis to benzimidazoles: a systematic review. PLoS Negl Trop Dis 3: e524.
Horton RJ, 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop 64: 79–93.
Cobo F, Yarnoz C, Sesma B, Fraile P, Aizcorbe M, Trujillo R, Diaz-de-Liano A, Ciga MA, 1998. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus. Trop Med Int Health 3: 462–466.
Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429–435.
Jamshidi M, Mohraz M, Zangeneh M, Jamshidi A, 2008. The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment. Parasitol Res 103: 195–199.
Salto E, Juarez E, Roiz MP, Abad J, 1991. Combined chemotherapy (mebendazole plus praziquantel) in patients with hydatidosis. Enferm Infecc Microbiol Clin 9: 527–529.
Jevtic M, Mikic D, Arsic-Komljenovic G, Stankovic N, Ristanovic E, Sjenicic G, Janicijevic-Hudomal S, 2008. Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease. Vojnosanit Pregl 65: 539–544.
Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603–605.
el-Hawey AM, Massoud AM, el-Rakieby A, Rozeik MS, Nassar MO, 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599–605.
Lima RM, Ferreira MA, de Jesus Ponte Carvalho TM, Dumet Fernandes BJ, Takayanagui OM, Garcia HH, Coelho EB, Lanchote VL, 2011. Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity. Br J Clin Pharmacol 71: 528–535.
Namwanje H, Kabatereine N, Olsen A, 2011. A randomized controlled clinical trial on the safety of co-administration of albendazole, ivermectin and praziquantel in infected schoolchildren in Uganda. Trans R Soc Trop Med Hyg 105: 181–188.
Kaur S, Singhi P, Singhi S, Khandelwal N, 2009. Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J 28: 403–406.
Mohammed KA, Haji HJ, Gabrielli AF, Mubila L, Biswas G, Chitsulo L, Bradley MH, Engels D, Savioli L, Molyneux DH, 2008. Triple co-administration of ivermectin, albendazole and praziquantel in Zanzibar: a safety study. PLoS Negl Trop Dis 2: e171.
WHO, 2003. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 85: 253–261.
Witassek F, Burkhardt B, Eckert J, Bircher J, 1981. Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man. Eur J Clin Pharmacol 20: 427–433.
Morris DL, Taylor DH, 1988. Optimal timing of post-operative albendazole prophylaxis in E. granulosus. Ann Trop Med Parasitol 82: 65–66.
Gollackner B, Langle F, Auer H, Maier A, Mittlbock M, Agstner I, Karner J, Langer F, Aspock H, Loidolt H, Rockenschaub S, Steininger R, 2000. Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J Surg 24: 717–721.
Gavidia CM, Gonzalez AE, Barron EA, Ninaquispe B, Llamosas M, Verastegui MR, Robinson C, Gilman RH, 2010. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4: e616.
Morris DL, Richards KS, Clarkson MJ, Taylor DH, 1990. Comparison of albendazole and praziquantel therapy of Echinococcus granulosus in naturally infected sheep. Vet Parasitol 36: 83–90.
Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429–435.
el Hawey AM, Massoud AM, el Rakieby A, Rozeik MS, Nassar MO, 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599–605.
Jaoko WG, Muchemi G, Oguya FO, 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499–501.
Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603–605.
Jaoko WG, Muchemi G, Oguya FO, 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499–501.
Alvela-Suarez L, Novo-Veleiro I, Belhassen-Garcia M, Velasco-Tirado V, Jimenez-Cabrera S, Iglesias-Gomez A, Cordero-Sanchez M, 2011. Dysgeusia as an adverse reaction to praziquantel. Drug Chem Toxicol 35: 116–117.
Winning A, Braslins P, McCarthy JS, 2009. Case report: nitazoxanide for treatment of refractory bony hydatid disease. Am J Trop Med Hyg 80: 176–178.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 3206 | 2606 | 537 |
Full Text Views | 826 | 14 | 0 |
PDF Downloads | 443 | 15 | 0 |
There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and hydatid cyst size. When surgery is not possible, medical treatment is indicated. Traditionally, albendazole was used in monotherapy as the standard treatment. However, combined therapy with albendazole plus praziquantel appears to improve anti-parasitic effectiveness. To date, no safety studies focusing on such combined therapy have been published for the treatment of hydatidosis. In this work, we analyze the adverse effects seen in 57 patients diagnosed with hydatidosis who were treated with praziquantel plus albendazole combined therapy between 2006 and 2010.
Authors' addresses: Lucía Alvela-Suárez, Virginia Velasco-Tirado, and Ignacio Novo-Veleiro, CAUSA, Internal Medicine, Salamanca, Spain, E-mails: luciaalvela@hotmail.com, virvela@yahoo.es, and ignacio.novo.veleiro@gmail.com. Moncef Belhassen-Garcia, CAUSA, Internal Medicina and Infectious Diseases, Salamanca, Spain, E-mail: mbelhassen@hotmail.com. Javier Pardo-Lledías, General Hospital of Palencia “Río Carrión” - Internal Medicine, Palencia, Spain, E-mail: javipard2@hotmail.com. Angela Romero-Alegría, CAUSA, Internal Medicine, Salamanca, Spain, E-mail: aralegria@yahoo.es. Luis Pérez del Villar, University of Salamanca - CIETUS, IBSAL, Salamanca, Spain, E-mail: luipmoro@usal.es. María Paz Valverde-Merino, CAUSA, Pharmacy Service, Salamanca, Spain, E-mail: mpvalverde@saludcastillayleon.es. Miguel Cordero-Sánchez, CAUSA, Infectious Diseases, Salamanca, Spain, E-mail: magnus@usal.es.
Budke CM, Deplazes P, Torgerson PR, 2006. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis 12: 296–303.
Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L, 2007. Control of neglected tropical diseases. N Engl J Med 357: 1018–1027.
Seimenis A, 2003. Overview of the epidemiological situation on echinococcosis in the Mediterranean region. Acta Trop 85: 191–195.
Sotiraki S, Himonas C, Korkoliakou P, 2003. Hydatidosis-echinococcosis in Greece. Acta Trop 85: 197–201.
Lorenzini R, Ruggieri A, 1987. Distribution of echinococcosis/hydatidosis in Italy. J Helminthol 61: 261–267.
Rojo-Vazquez FA, Pardo-Lledias J, Francos-Von Hunefeld M, Cordero-Sanchez M, Alamo-Sanz R, Hernandez-Gonzalez A, Brunetti E, Siles-Lucas M, 2011. Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe. PLoS Negl Trop Dis 5: e893.
Pardo J, Muro A, Galindo I, Cordero M, Carpio A, Siles-Lucas M, 2005. Hydatidosis in the province of Salamanca (Spain): should we let down our guard? Enferm Infecc Microbiol Clin 23: 266–269.
Vuitton DA, 2009. Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus? Expert Rev Anti Infect Ther 7: 145–149.
WHO, 1996. Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis. Bull World Health Organ 74: 231–242.
Menezes da Silva A, 2003. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop 85: 237–242.
Smego RA Jr, Sebanego P, 2005. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 9: 69–76.
Silva MA, Mirza DF, Bramhall SR, Mayer AD, McMaster P, Buckels JA, 2004. Treatment of hydatid disease of the liver. Evaluation of a UK experience. Dig Surg 21: 227–233, discussion 233–234.
Pelaez V, Kugler C, Correa D, Del Carpio M, Guangiroli M, Molina J, Marcos B, Lopez E, 2000. PAIR as percutaneous treatment of hydatid liver cysts. Acta Trop 75: 197–202.
Ustunsoz B, Akhan O, Kamiloglu MA, Somuncu I, Ugurel MS, Cetiner S, 1999. Percutaneous treatment of hydatid cysts of the liver: long-term results. AJR Am J Roentgenol 172: 91–96.
Filice C, Brunetti E, Bruno R, Crippa FG, 2000. Percutaneous drainage of echinococcal cysts (PAIR–puncture, aspiration, injection, reaspiration): results of a worldwide survey for assessment of its safety and efficacy. WHO-Informal Working Group on Echinococcosis-Pair Network. Gut 47: 156–157.
Perez-Molina JA, Diaz-Menendez M, Gallego JI, Norman F, Monge-Maillo B, Ayala AP, Lopez-Velez R, 2011. Evaluation of nitazoxanide for the treatment of disseminated cystic echinococcosis: report of five cases and literature review. Am J Trop Med Hyg 84: 351–356.
Mohamed AE, Yasawy MI, Al Karawi MA, 1998. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology 45: 1690–1694.
Yasawy MI, al Karawi MA, Mohamed AR, 1993. Combination of praziquantel and albendazole in the treatment of hydatid disease. Trop Med Parasitol 44: 192–194.
El-On J, 2003. Benzimidazole treatment of cystic echinococcosis. Acta Trop 85: 243–252.
Falagas ME, Bliziotis IA, 2007. Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials. Am J Med Sci 334: 171–179.
Stojkovic M, Zwahlen M, Teggi A, Vutova K, Cretu CM, Virdone R, Nicolaidou P, Cobanoglu N, Junghanss T, 2009. Treatment response of cystic echinococcosis to benzimidazoles: a systematic review. PLoS Negl Trop Dis 3: e524.
Horton RJ, 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop 64: 79–93.
Cobo F, Yarnoz C, Sesma B, Fraile P, Aizcorbe M, Trujillo R, Diaz-de-Liano A, Ciga MA, 1998. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus. Trop Med Int Health 3: 462–466.
Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429–435.
Jamshidi M, Mohraz M, Zangeneh M, Jamshidi A, 2008. The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment. Parasitol Res 103: 195–199.
Salto E, Juarez E, Roiz MP, Abad J, 1991. Combined chemotherapy (mebendazole plus praziquantel) in patients with hydatidosis. Enferm Infecc Microbiol Clin 9: 527–529.
Jevtic M, Mikic D, Arsic-Komljenovic G, Stankovic N, Ristanovic E, Sjenicic G, Janicijevic-Hudomal S, 2008. Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease. Vojnosanit Pregl 65: 539–544.
Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603–605.
el-Hawey AM, Massoud AM, el-Rakieby A, Rozeik MS, Nassar MO, 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599–605.
Lima RM, Ferreira MA, de Jesus Ponte Carvalho TM, Dumet Fernandes BJ, Takayanagui OM, Garcia HH, Coelho EB, Lanchote VL, 2011. Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity. Br J Clin Pharmacol 71: 528–535.
Namwanje H, Kabatereine N, Olsen A, 2011. A randomized controlled clinical trial on the safety of co-administration of albendazole, ivermectin and praziquantel in infected schoolchildren in Uganda. Trans R Soc Trop Med Hyg 105: 181–188.
Kaur S, Singhi P, Singhi S, Khandelwal N, 2009. Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J 28: 403–406.
Mohammed KA, Haji HJ, Gabrielli AF, Mubila L, Biswas G, Chitsulo L, Bradley MH, Engels D, Savioli L, Molyneux DH, 2008. Triple co-administration of ivermectin, albendazole and praziquantel in Zanzibar: a safety study. PLoS Negl Trop Dis 2: e171.
WHO, 2003. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 85: 253–261.
Witassek F, Burkhardt B, Eckert J, Bircher J, 1981. Chemotherapy of alveolar echinococcosis. Comparison of plasma mebendazole concentrations in animals and man. Eur J Clin Pharmacol 20: 427–433.
Morris DL, Taylor DH, 1988. Optimal timing of post-operative albendazole prophylaxis in E. granulosus. Ann Trop Med Parasitol 82: 65–66.
Gollackner B, Langle F, Auer H, Maier A, Mittlbock M, Agstner I, Karner J, Langer F, Aspock H, Loidolt H, Rockenschaub S, Steininger R, 2000. Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J Surg 24: 717–721.
Gavidia CM, Gonzalez AE, Barron EA, Ninaquispe B, Llamosas M, Verastegui MR, Robinson C, Gilman RH, 2010. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis 4: e616.
Morris DL, Richards KS, Clarkson MJ, Taylor DH, 1990. Comparison of albendazole and praziquantel therapy of Echinococcus granulosus in naturally infected sheep. Vet Parasitol 36: 83–90.
Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A, Roilides E, Giannoulis E, 2008. Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol 21: 429–435.
el Hawey AM, Massoud AM, el Rakieby A, Rozeik MS, Nassar MO, 1990. Side effects of praziquantel in bilharzial children on a field level. J Egypt Soc Parasitol 20: 599–605.
Jaoko WG, Muchemi G, Oguya FO, 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499–501.
Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST, 2007. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 76: 603–605.
Jaoko WG, Muchemi G, Oguya FO, 1996. Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East Afr Med J 73: 499–501.
Alvela-Suarez L, Novo-Veleiro I, Belhassen-Garcia M, Velasco-Tirado V, Jimenez-Cabrera S, Iglesias-Gomez A, Cordero-Sanchez M, 2011. Dysgeusia as an adverse reaction to praziquantel. Drug Chem Toxicol 35: 116–117.
Winning A, Braslins P, McCarthy JS, 2009. Case report: nitazoxanide for treatment of refractory bony hydatid disease. Am J Trop Med Hyg 80: 176–178.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 3206 | 2606 | 537 |
Full Text Views | 826 | 14 | 0 |
PDF Downloads | 443 | 15 | 0 |