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Biochemical and Hematologic Parameters for Children in the Middle Belt of Ghana
Reference values derived from developed countries are used in many countries in Africa for interpretation of laboratory results obtained during routine healthcare and clinical trials. Use of locally derived reference values has been recommended. The purpose of the study was to establish age- and sex-specific reference values for children in the middle belt of Ghana. Reference values were determined for 21 biochemical and 18 hematologic parameters by using Clinical and Laboratory Standards Institute C28-A3 guidelines in a sample of 1,442 healthy children. Hemoglobin, hematocrit, mean cell volume, erythrocytes, urea, and creatinine were lower when compared with values from northern countries but alanine aminotransferase, aspartate aminotransferase, and total bilirubin were higher. A panel of locally relevant age- and sex-specific reference values was established for commonly used biochemical and hematologic tests in children in the middle part of Ghana. This will help in interpretation of laboratory results for clinical management of patients, screening, and safety monitoring during clinical trials.
Author Notes
Financial support: This study was supported by the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health of the United States Contract no. HHSN266200400016C awarded to the Noguchi Memorial Institute for Medical Research and a subcontract to the Kintampo Health Research Centre.
Disclosure: None of the authors has any conflicts of interest.
Authors' addresses: David K. Dosoo, Kwaku P. Asante, Kingsley Kayan, Dennis Adu-Gyasi, Kingsley Osei-Kwakye, Emmanuel Mahama, Samuel Danso, Stephen Amenga-Etego, Philip Bilson, and Seth Owusu-Agyei, Kintampo Health Research Centre, Kintampo, Ghana, E-mails: david.dosoo@kintampo-hrc.org, dennis.adu-gyasi@kintampo-hrc.org, kayan.kingsley@kintampo-hrc.org, kingsley.osei-kwakye@kintampo-hrc.org, mahana@kintampo-hrc.org, samuel.danso@kintampo-hrc.org, seeba.ae@kintampo-hrc.org, phillip.bilson@kintampo-hrc.org, and seth.owusu-agyei@kintampo-hrc.org. Kwadwo A. Koram, Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana, E-mail: kkoram@noguchi.mimcom.org.